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P91252

- GST6_CAEEL

UniProt

P91252 - GST6_CAEEL

Protein

Probable glutathione S-transferase 6

Gene

gst-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei14 – 141GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei43 – 431GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. innate immune response Source: WormBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione S-transferase 6 (EC:2.5.1.18)
    Alternative name(s):
    GST class-sigma
    Gene namesi
    Name:gst-6
    ORF Names:F11G11.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF11G11.3; CE32622; WBGene00001754; gst-6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Probable glutathione S-transferase 6PRO_0000185929Add
    BLAST

    Proteomic databases

    PaxDbiP91252.
    PRIDEiP91252.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F11G11.3.

    Structurei

    3D structure databases

    ProteinModelPortaliP91252.
    SMRiP91252. Positions 1-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7978GST N-terminalAdd
    BLAST
    Domaini81 – 206126GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Glutathione bindingBy similarity
    Regioni63 – 642Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Sigma family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG122057.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115733.
    InParanoidiP91252.
    KOiK00799.
    OMAiKDYLNDV.
    OrthoDBiEOG78WKT1.
    PhylomeDBiP91252.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P91252-1 [UniParc]FASTAAdd to Basket

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    MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ    50
    LPILEVDGKP LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN 100
    DVSPYLTVLA GFKPGDKDQL RTDVFVPAFK KNFEFFENIL ASNHSGFFVG 150
    NSLTWVDLLI SQHVQDILDK DLAVVEEFKK VLAHRKKVQS IDRIQKYIAN 200
    RPDYPF 206
    Length:206
    Mass (Da):23,617
    Last modified:March 1, 2003 - v2
    Checksum:i347CF944862A1571
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081119 Genomic DNA. Translation: CCD69256.1.
    PIRiT29984.
    RefSeqiNP_494882.2. NM_062481.7.
    UniGeneiCel.14875.

    Genome annotation databases

    EnsemblMetazoaiF11G11.3; F11G11.3; WBGene00001754.
    GeneIDi173841.
    KEGGicel:CELE_F11G11.3.
    UCSCiF11G11.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081119 Genomic DNA. Translation: CCD69256.1 .
    PIRi T29984.
    RefSeqi NP_494882.2. NM_062481.7.
    UniGenei Cel.14875.

    3D structure databases

    ProteinModelPortali P91252.
    SMRi P91252. Positions 1-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F11G11.3.

    Proteomic databases

    PaxDbi P91252.
    PRIDEi P91252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F11G11.3 ; F11G11.3 ; WBGene00001754 .
    GeneIDi 173841.
    KEGGi cel:CELE_F11G11.3.
    UCSCi F11G11.3. c. elegans.

    Organism-specific databases

    CTDi 173841.
    WormBasei F11G11.3 ; CE32622 ; WBGene00001754 ; gst-6.

    Phylogenomic databases

    eggNOGi NOG122057.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115733.
    InParanoidi P91252.
    KOi K00799.
    OMAi KDYLNDV.
    OrthoDBi EOG78WKT1.
    PhylomeDBi P91252.

    Miscellaneous databases

    NextBioi 881349.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGST6_CAEEL
    AccessioniPrimary (citable) accession number: P91252
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3