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P91252

- GST6_CAEEL

UniProt

P91252 - GST6_CAEEL

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Protein

Probable glutathione S-transferase 6

Gene
gst-6, F11G11.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei14 – 141Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei43 – 431Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 6 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-6
ORF Names:F11G11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF11G11.3; CE32622; WBGene00001754; gst-6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 6PRO_0000185929Add
BLAST

Proteomic databases

PaxDbiP91252.
PRIDEiP91252.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.3.

Structurei

3D structure databases

ProteinModelPortaliP91252.
SMRiP91252. Positions 1-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione binding By similarity
Regioni63 – 642Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.By similarity

Phylogenomic databases

eggNOGiNOG122057.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91252.
KOiK00799.
OMAiKDYLNDV.
OrthoDBiEOG78WKT1.
PhylomeDBiP91252.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91252-1 [UniParc]FASTAAdd to Basket

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MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ    50
LPILEVDGKP LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN 100
DVSPYLTVLA GFKPGDKDQL RTDVFVPAFK KNFEFFENIL ASNHSGFFVG 150
NSLTWVDLLI SQHVQDILDK DLAVVEEFKK VLAHRKKVQS IDRIQKYIAN 200
RPDYPF 206
Length:206
Mass (Da):23,617
Last modified:March 1, 2003 - v2
Checksum:i347CF944862A1571
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69256.1.
PIRiT29984.
RefSeqiNP_494882.2. NM_062481.7.
UniGeneiCel.14875.

Genome annotation databases

EnsemblMetazoaiF11G11.3; F11G11.3; WBGene00001754.
GeneIDi173841.
KEGGicel:CELE_F11G11.3.
UCSCiF11G11.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69256.1 .
PIRi T29984.
RefSeqi NP_494882.2. NM_062481.7.
UniGenei Cel.14875.

3D structure databases

ProteinModelPortali P91252.
SMRi P91252. Positions 1-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F11G11.3.

Proteomic databases

PaxDbi P91252.
PRIDEi P91252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F11G11.3 ; F11G11.3 ; WBGene00001754 .
GeneIDi 173841.
KEGGi cel:CELE_F11G11.3.
UCSCi F11G11.3. c. elegans.

Organism-specific databases

CTDi 173841.
WormBasei F11G11.3 ; CE32622 ; WBGene00001754 ; gst-6.

Phylogenomic databases

eggNOGi NOG122057.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi P91252.
KOi K00799.
OMAi KDYLNDV.
OrthoDBi EOG78WKT1.
PhylomeDBi P91252.

Miscellaneous databases

NextBioi 881349.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST6_CAEEL
AccessioniPrimary (citable) accession number: P91252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi