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P91252

- GST6_CAEEL

UniProt

P91252 - GST6_CAEEL

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Protein

Probable glutathione S-transferase 6

Gene

gst-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_183741. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 6 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-6
ORF Names:F11G11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF11G11.3; CE32622; WBGene00001754; gst-6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 6PRO_0000185929Add
BLAST

Proteomic databases

PaxDbiP91252.
PRIDEiP91252.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.3.

Structurei

3D structure databases

ProteinModelPortaliP91252.
SMRiP91252. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG122057.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91252.
KOiK00799.
OMAiKDYLNDV.
OrthoDBiEOG78WKT1.
PhylomeDBiP91252.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91252-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ
60 70 80 90 100
LPILEVDGKP LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN
110 120 130 140 150
DVSPYLTVLA GFKPGDKDQL RTDVFVPAFK KNFEFFENIL ASNHSGFFVG
160 170 180 190 200
NSLTWVDLLI SQHVQDILDK DLAVVEEFKK VLAHRKKVQS IDRIQKYIAN

RPDYPF
Length:206
Mass (Da):23,617
Last modified:March 1, 2003 - v2
Checksum:i347CF944862A1571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69256.1.
PIRiT29984.
RefSeqiNP_494882.2. NM_062481.7.
UniGeneiCel.14875.

Genome annotation databases

EnsemblMetazoaiF11G11.3; F11G11.3; WBGene00001754.
GeneIDi173841.
KEGGicel:CELE_F11G11.3.
UCSCiF11G11.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69256.1 .
PIRi T29984.
RefSeqi NP_494882.2. NM_062481.7.
UniGenei Cel.14875.

3D structure databases

ProteinModelPortali P91252.
SMRi P91252. Positions 1-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F11G11.3.

Proteomic databases

PaxDbi P91252.
PRIDEi P91252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F11G11.3 ; F11G11.3 ; WBGene00001754 .
GeneIDi 173841.
KEGGi cel:CELE_F11G11.3.
UCSCi F11G11.3. c. elegans.

Organism-specific databases

CTDi 173841.
WormBasei F11G11.3 ; CE32622 ; WBGene00001754 ; gst-6.

Phylogenomic databases

eggNOGi NOG122057.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi P91252.
KOi K00799.
OMAi KDYLNDV.
OrthoDBi EOG78WKT1.
PhylomeDBi P91252.

Enzyme and pathway databases

Reactomei REACT_183741. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_263468. Glutathione conjugation.

Miscellaneous databases

NextBioi 881349.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST6_CAEEL
AccessioniPrimary (citable) accession number: P91252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3