Reviewed, UniProtKB/Swiss-Prot P91252 (GST6_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable glutathione S-transferase 6
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma

Gene names

Name:	gst-6
ORF Names:	F11G11.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Probable glutathione S-transferase 6		PRO_0000185929
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 206	126	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P91252-1 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: 347CF944862A1571	FASTA	206	23,617
	10 20 30 40 50 60 MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ LPILEVDGKP 70 80 90 100 110 120 LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN DVSPYLTVLA GFKPGDKDQL 130 140 150 160 170 180 RTDVFVPAFK KNFEFFENIL ASNHSGFFVG NSLTWVDLLI SQHVQDILDK DLAVVEEFKK 190 200 VLAHRKKVQS IDRIQKYIAN RPDYPF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U80451 Genomic DNA. Translation: AAB37845.2.
PIR	T29984.
RefSeq	NP_494882.2.
UniGene	Cel.14875
3D structure databases
HSSP	HSSP built from PDB template 1GUK based on UniProtKB P24472.
ModBase	Search...
Protein-protein interaction databases
STRING	P91252.
Genome annotation databases
Ensembl	F11G11.3; F11G11.3; F11G11.3; Caenorhabditis elegans. [Genome view]
GeneID	173841.
KEGG	cel:F11G11.3.
NMPDR	fig|6239.3.peg.5314.
UCSC	F11G11.3. c. elegans.
Organism-specific databases
CTD	173841.
WormBase	WBGene00001754. gst-6.
WormPep	F11G11.3. CE32622. [WorfDB]
Phylogenomic databases
OMA	YAIARYL.
Enzyme and pathway databases
BRENDA	2.5.1.18. 672.
Gene expression databases
ArrayExpress	P91252.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	881349.

Entry information

Entry name

GST6_CAEEL

Accession

Primary (citable) accession number: P91252

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project