P91252 (GST6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione S-transferase 6
EC=2.5.1.18

Alternative name(s):
GST class-sigma

Gene names

Name:	gst-6
ORF Names:	F11G11.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Probable glutathione S-transferase 6		PRO_0000185929
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 206	126	GST C-terminal
	Region	50 – 51	2	Glutathione binding By similarity
	Region	63 – 64	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity
	Binding site	14	1	Glutathione By similarity
	Binding site	39	1	Glutathione By similarity
	Binding site	43	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P91252 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: 347CF944862A1571	FASTA	206	23,617
	10 20 30 40 50 60 MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ LPILEVDGKP 70 80 90 100 110 120 LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN DVSPYLTVLA GFKPGDKDQL 130 140 150 160 170 180 RTDVFVPAFK KNFEFFENIL ASNHSGFFVG NSLTWVDLLI SQHVQDILDK DLAVVEEFKK 190 200 VLAHRKKVQS IDRIQKYIAN RPDYPF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081119 Genomic DNA. Translation: CCD69256.1.
PIR	T29984.
RefSeq	NP_494882.2. NM_062481.7.
3D structure databases
ProteinModelPortal	P91252.
SMR	P91252. Positions 1-206.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F11G11.3.
Proteomic databases
PaxDb	P91252.
PRIDE	P91252.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F11G11.3; F11G11.3; F11G11.3.
GeneID	173841.
KEGG	cel:CELE_F11G11.3.
UCSC	F11G11.3. c. elegans.
Organism-specific databases
CTD	173841.
WormBase	F11G11.3; CE32622; WBGene00001754; gst-6.
Phylogenomic databases
eggNOG	NOG122057.
GeneTree	ENSGT00550000074559.
HOGENOM	HOG000115733.
InParanoid	P91252.
KO	K00799.
OMA	ISFADYR.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	881349.

Entry information

Entry name

GST6_CAEEL

Accession

Primary (citable) accession number: P91252

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project