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P91119

- PDE5_CAEEL

UniProt

P91119 - PDE5_CAEEL

Protein

Probable 3',5'-cyclic phosphodiesterase pde-5

Gene

pde-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651Proton donorBy similarity
    Metal bindingi469 – 4691Divalent metal cation 1By similarity
    Metal bindingi503 – 5031Divalent metal cation 1By similarity
    Metal bindingi504 – 5041Divalent metal cation 1By similarity
    Metal bindingi504 – 5041Divalent metal cation 2By similarity
    Metal bindingi614 – 6141Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3',5'-cyclic phosphodiesterase pde-5 (EC:3.1.4.17)
    Gene namesi
    Name:pde-5
    ORF Names:C32E12.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiC32E12.2; CE45692; WBGene00016328; pde-5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Probable 3',5'-cyclic phosphodiesterase pde-5PRO_0000198848Add
    BLAST

    Proteomic databases

    PaxDbiP91119.
    PRIDEiP91119.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C32E12.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP91119.
    SMRiP91119. Positions 194-709.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini214 – 371158GAFAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili691 – 72838Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GAF domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270709.
    GeneTreeiENSGT00750000117253.
    HOGENOMiHOG000007068.
    InParanoidiP91119.
    KOiK01120.
    OMAiHENIAKQ.
    OrthoDBiEOG7WQ7RN.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 1 hit.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 1 hit.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 1 hit.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 1 hit.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P91119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDASVLKYL QENPKLVEDF VVSNEISPET FKRWAVRRTM KYKNVKNGTS    50
    GGTGAWTEPD LSMKRRVILE TSDNRTRILY EITQCCGQLI GTNSIELIVQ 100
    NDEGAFSCRK TENGELKLKK VKTSKSADYI QTIVNAGNQT IAEIHFYTQL 150
    DSTEKSIVNA VCTWAAATNY YSELYTHKQE GSDGQDIHEN IAKQRKLSNF 200
    LLDVARSIFH DIVSMDAVII KVMNFAQKLV DADRASLFLV DSKNAQIYAR 250
    IFDVGTGDEE HVRVNSEGQK EIRFDMSKGI AGYVASTGEG LNIENAYEDE 300
    RFNADVDSKT GYTTKTILCM PILIRGIVIG VVQMVNKHDG VFTRQDEDAF 350
    EIFAVYCGLA LHHAKLYDKI RRSEQKYRVA LEVLAYHSVC NADEVNKLKK 400
    IEINNRIVEL ETIDFNGMRL SELEKPLYAV YMFKTLFADT LRFDTEDLIR 450
    FVLTVRKNYR RVAYHNWAHG WSVAHAMFAT LMNSPDAFTK LEALALYVSC 500
    LCHDLDHRGK NNAYMKTMST PLASIYSTSV MERHHFNQTV TILQQDGHNI 550
    LKSLSSEDYK KTLSLIKHCI LATDLALFFS NKAKLNVILD NNTFDINRQE 600
    HRLLTQAVMM TGCDLVASAK PWNIQTETVK VIFEEFYDQG DAERLSGKEP 650
    IPMMDRQQAH MLPQMQVGFM RGICMPCYDL IARIFPKNDK MRERCEYNAK 700
    KWEELAEEQR KKQEALAQQN GEANETQE 728
    Length:728
    Mass (Da):83,227
    Last modified:October 19, 2011 - v3
    Checksum:i7C28EC4EEEC16D85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080144 Genomic DNA. Translation: CCD61583.1.
    PIRiT25590.
    RefSeqiNP_491544.3. NM_059143.3.
    UniGeneiCel.19170.

    Genome annotation databases

    EnsemblMetazoaiC32E12.2; C32E12.2; WBGene00016328.
    GeneIDi183125.
    KEGGicel:CELE_C32E12.2.
    UCSCiC32E12.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080144 Genomic DNA. Translation: CCD61583.1 .
    PIRi T25590.
    RefSeqi NP_491544.3. NM_059143.3.
    UniGenei Cel.19170.

    3D structure databases

    ProteinModelPortali P91119.
    SMRi P91119. Positions 194-709.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C32E12.2.

    Proteomic databases

    PaxDbi P91119.
    PRIDEi P91119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C32E12.2 ; C32E12.2 ; WBGene00016328 .
    GeneIDi 183125.
    KEGGi cel:CELE_C32E12.2.
    UCSCi C32E12.2. c. elegans.

    Organism-specific databases

    CTDi 183125.
    WormBasei C32E12.2 ; CE45692 ; WBGene00016328 ; pde-5.

    Phylogenomic databases

    eggNOGi NOG270709.
    GeneTreei ENSGT00750000117253.
    HOGENOMi HOG000007068.
    InParanoidi P91119.
    KOi K01120.
    OMAi HENIAKQ.
    OrthoDBi EOG7WQ7RN.

    Miscellaneous databases

    NextBioi 920014.
    PROi P91119.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 1 hit.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 1 hit.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 1 hit.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 1 hit.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDE5_CAEEL
    AccessioniPrimary (citable) accession number: P91119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3