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P91119

- PDE5_CAEEL

UniProt

P91119 - PDE5_CAEEL

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Protein
Probable 3',5'-cyclic phosphodiesterase pde-5
Gene
pde-5, C32E12.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651Proton donor By similarity
Metal bindingi469 – 4691Divalent metal cation 1 By similarity
Metal bindingi503 – 5031Divalent metal cation 1 By similarity
Metal bindingi504 – 5041Divalent metal cation 1 By similarity
Metal bindingi504 – 5041Divalent metal cation 2 By similarity
Metal bindingi614 – 6141Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-5 (EC:3.1.4.17)
Gene namesi
Name:pde-5
ORF Names:C32E12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiC32E12.2; CE45692; WBGene00016328; pde-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Probable 3',5'-cyclic phosphodiesterase pde-5
PRO_0000198848Add
BLAST

Proteomic databases

PaxDbiP91119.
PRIDEiP91119.

Interactioni

Protein-protein interaction databases

STRINGi6239.C32E12.2.

Structurei

3D structure databases

ProteinModelPortaliP91119.
SMRiP91119. Positions 194-709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini214 – 371158GAF
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili691 – 72838 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 GAF domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270709.
GeneTreeiENSGT00750000117253.
HOGENOMiHOG000007068.
InParanoidiP91119.
KOiK01120.
OMAiHENIAKQ.
OrthoDBiEOG7WQ7RN.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 1 hit.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 1 hit.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91119-1 [UniParc]FASTAAdd to Basket

« Hide

MDDASVLKYL QENPKLVEDF VVSNEISPET FKRWAVRRTM KYKNVKNGTS    50
GGTGAWTEPD LSMKRRVILE TSDNRTRILY EITQCCGQLI GTNSIELIVQ 100
NDEGAFSCRK TENGELKLKK VKTSKSADYI QTIVNAGNQT IAEIHFYTQL 150
DSTEKSIVNA VCTWAAATNY YSELYTHKQE GSDGQDIHEN IAKQRKLSNF 200
LLDVARSIFH DIVSMDAVII KVMNFAQKLV DADRASLFLV DSKNAQIYAR 250
IFDVGTGDEE HVRVNSEGQK EIRFDMSKGI AGYVASTGEG LNIENAYEDE 300
RFNADVDSKT GYTTKTILCM PILIRGIVIG VVQMVNKHDG VFTRQDEDAF 350
EIFAVYCGLA LHHAKLYDKI RRSEQKYRVA LEVLAYHSVC NADEVNKLKK 400
IEINNRIVEL ETIDFNGMRL SELEKPLYAV YMFKTLFADT LRFDTEDLIR 450
FVLTVRKNYR RVAYHNWAHG WSVAHAMFAT LMNSPDAFTK LEALALYVSC 500
LCHDLDHRGK NNAYMKTMST PLASIYSTSV MERHHFNQTV TILQQDGHNI 550
LKSLSSEDYK KTLSLIKHCI LATDLALFFS NKAKLNVILD NNTFDINRQE 600
HRLLTQAVMM TGCDLVASAK PWNIQTETVK VIFEEFYDQG DAERLSGKEP 650
IPMMDRQQAH MLPQMQVGFM RGICMPCYDL IARIFPKNDK MRERCEYNAK 700
KWEELAEEQR KKQEALAQQN GEANETQE 728
Length:728
Mass (Da):83,227
Last modified:October 19, 2011 - v3
Checksum:i7C28EC4EEEC16D85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080144 Genomic DNA. Translation: CCD61583.1.
PIRiT25590.
RefSeqiNP_491544.3. NM_059143.3.
UniGeneiCel.19170.

Genome annotation databases

EnsemblMetazoaiC32E12.2; C32E12.2; WBGene00016328.
GeneIDi183125.
KEGGicel:CELE_C32E12.2.
UCSCiC32E12.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080144 Genomic DNA. Translation: CCD61583.1 .
PIRi T25590.
RefSeqi NP_491544.3. NM_059143.3.
UniGenei Cel.19170.

3D structure databases

ProteinModelPortali P91119.
SMRi P91119. Positions 194-709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C32E12.2.

Proteomic databases

PaxDbi P91119.
PRIDEi P91119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C32E12.2 ; C32E12.2 ; WBGene00016328 .
GeneIDi 183125.
KEGGi cel:CELE_C32E12.2.
UCSCi C32E12.2. c. elegans.

Organism-specific databases

CTDi 183125.
WormBasei C32E12.2 ; CE45692 ; WBGene00016328 ; pde-5.

Phylogenomic databases

eggNOGi NOG270709.
GeneTreei ENSGT00750000117253.
HOGENOMi HOG000007068.
InParanoidi P91119.
KOi K01120.
OMAi HENIAKQ.
OrthoDBi EOG7WQ7RN.

Miscellaneous databases

NextBioi 920014.
PROi P91119.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 1 hit.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 1 hit.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 1 hit.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 1 hit.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE5_CAEEL
AccessioniPrimary (citable) accession number: P91119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi