Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 3',5'-cyclic phosphodiesterase pde-5

Gene

pde-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.1 Publication

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton donorBy similarity1
Metal bindingi469Divalent metal cation 1By similarity1
Metal bindingi503Divalent metal cation 1By similarity1
Metal bindingi504Divalent metal cation 1By similarity1
Metal bindingi504Divalent metal cation 2By similarity1
Metal bindingi614Divalent metal cation 1By similarity1

GO - Molecular functioni

  • 3',5'-cyclic-GMP phosphodiesterase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • microvillus organization Source: WormBase
  • negative regulation of cGMP-mediated signaling Source: UniProtKB
  • phototransduction Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • response to alkaline pH Source: UniProtKB
  • response to hydrogen peroxide Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-418457 cGMP effects
R-CEL-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-5 (EC:3.1.4.17)
Gene namesi
Name:pde-5
ORF Names:C32E12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC32E12.2 ; CE45692 ; WBGene00016328 ; pde-5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988481 – 728Probable 3',5'-cyclic phosphodiesterase pde-5Add BLAST728

Proteomic databases

EPDiP91119
PaxDbiP91119
PeptideAtlasiP91119
PRIDEiP91119

Expressioni

Gene expression databases

BgeeiWBGene00016328

Interactioni

Protein-protein interaction databases

BioGridi47958, 1 interactor
STRINGi6239.C32E12.2

Structurei

3D structure databases

ProteinModelPortaliP91119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 371GAFAdd BLAST158
Domaini390 – 709PDEasePROSITE-ProRule annotationAdd BLAST320

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili691 – 728Sequence analysisAdd BLAST38

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007068
InParanoidiP91119
KOiK18438
OMAiLKACRNN
OrthoDBiEOG091G037C

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 1 hit
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

P91119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDASVLKYL QENPKLVEDF VVSNEISPET FKRWAVRRTM KYKNVKNGTS
60 70 80 90 100
GGTGAWTEPD LSMKRRVILE TSDNRTRILY EITQCCGQLI GTNSIELIVQ
110 120 130 140 150
NDEGAFSCRK TENGELKLKK VKTSKSADYI QTIVNAGNQT IAEIHFYTQL
160 170 180 190 200
DSTEKSIVNA VCTWAAATNY YSELYTHKQE GSDGQDIHEN IAKQRKLSNF
210 220 230 240 250
LLDVARSIFH DIVSMDAVII KVMNFAQKLV DADRASLFLV DSKNAQIYAR
260 270 280 290 300
IFDVGTGDEE HVRVNSEGQK EIRFDMSKGI AGYVASTGEG LNIENAYEDE
310 320 330 340 350
RFNADVDSKT GYTTKTILCM PILIRGIVIG VVQMVNKHDG VFTRQDEDAF
360 370 380 390 400
EIFAVYCGLA LHHAKLYDKI RRSEQKYRVA LEVLAYHSVC NADEVNKLKK
410 420 430 440 450
IEINNRIVEL ETIDFNGMRL SELEKPLYAV YMFKTLFADT LRFDTEDLIR
460 470 480 490 500
FVLTVRKNYR RVAYHNWAHG WSVAHAMFAT LMNSPDAFTK LEALALYVSC
510 520 530 540 550
LCHDLDHRGK NNAYMKTMST PLASIYSTSV MERHHFNQTV TILQQDGHNI
560 570 580 590 600
LKSLSSEDYK KTLSLIKHCI LATDLALFFS NKAKLNVILD NNTFDINRQE
610 620 630 640 650
HRLLTQAVMM TGCDLVASAK PWNIQTETVK VIFEEFYDQG DAERLSGKEP
660 670 680 690 700
IPMMDRQQAH MLPQMQVGFM RGICMPCYDL IARIFPKNDK MRERCEYNAK
710 720
KWEELAEEQR KKQEALAQQN GEANETQE
Length:728
Mass (Da):83,227
Last modified:October 19, 2011 - v3
Checksum:i7C28EC4EEEC16D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080144 Genomic DNA Translation: CCD61583.1
PIRiT25590
RefSeqiNP_491544.3, NM_059143.3
UniGeneiCel.19170

Genome annotation databases

EnsemblMetazoaiC32E12.2; C32E12.2; WBGene00016328
GeneIDi183125
KEGGicel:CELE_C32E12.2
UCSCiC32E12.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPDE5_CAEEL
AccessioniPrimary (citable) accession number: P91119
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health