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P91079

- SPTC1_CAEEL

UniProt

P91079 - SPTC1_CAEEL

Protein

Serine palmitoyltransferase 1

Gene

sptl-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 By similarity. Required for the specification of abicobasal polarity and development of the gut lumen.By similarity1 Publication

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
    3. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_183003. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine palmitoyltransferase 1 (EC:2.3.1.50)
    Alternative name(s):
    Long chain base biosynthesis protein 1
    Short name:
    LCB 1
    Serine-palmitoyl-CoA transferase 1
    Short name:
    SPT 1
    Short name:
    SPT1
    Gene namesi
    Name:sptl-1
    ORF Names:C23H3.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC23H3.4a; CE08323; WBGene00016020; sptl-1.
    C23H3.4b; CE37749; WBGene00016020; sptl-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Serine palmitoyltransferase 1PRO_0000421271Add
    BLAST

    Proteomic databases

    PaxDbiP91079.
    PRIDEiP91079.

    Interactioni

    Subunit structurei

    Heterodimer of sptl-1/sptl-2 or sptl-1/sptl-3.By similarity

    Protein-protein interaction databases

    IntActiP91079. 1 interaction.
    MINTiMINT-213137.
    STRINGi6239.C23H3.4a.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP91079.
    SMRiP91079. Positions 76-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    GeneTreeiENSGT00550000074872.
    HOGENOMiHOG000216602.
    InParanoidiP91079.
    OMAiTEMAING.
    PhylomeDBiP91079.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P91079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFLPDSWHF YIETLLVALL AYVVMRNRSK RQQEKLSKKL TERQKDELIA    50
    DWTPEPLVPE TPQDHPVLNP KYADGKMTKD VSIDGEKYLN MASTNFLSFI 100
    GVKRIEDRAK QTIFKYGVGS CGPRGFYGTV DVHLDLEKEL AKFMGCEEAV 150
    LYSYGFATVS SAIPAYAKKG DVIFVDEGVN FAIQKGLQAS RSRVEYFKHN 200
    DMEHLERLLL EQEQRDKKDP KKAKSVRRFI VVEGLYVNYA DLCPLPKIIE 250
    FKWRFKVRVF IDESWSFGVI GKTGRGVTEH FNVPMEDVDM VMASLENALA 300
    STGGFCVGRS YVVGHQRLSG LGYCFSASLP PLLATAASEA ISIIDEEPSR 350
    VQKVTEMAIN GQKKLQDALS GSKFSLQGCP ESPMKHIYYN GEDEEKQLDT 400
    FVETVFTKNH LLLTRARYLD KDELFKIRPS IRVMFQHDLT EEEIQRAVDA 450
    IRVVAHKF 458
    Length:458
    Mass (Da):52,085
    Last modified:May 1, 1997 - v1
    Checksum:i2F56AC94DFFABF91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080632 Genomic DNA. Translation: CCD65323.1.
    FO080632 Genomic DNA. Translation: CCD65324.1.
    PIRiT25557.
    RefSeqiNP_001021978.1. NM_001026807.2.
    NP_001021979.1. NM_001026808.2.
    UniGeneiCel.8663.

    Genome annotation databases

    EnsemblMetazoaiC23H3.4a.1; C23H3.4a.1; WBGene00016020.
    C23H3.4a.2; C23H3.4a.2; WBGene00016020.
    GeneIDi173389.
    KEGGicel:CELE_C23H3.4.
    UCSCiC23H3.4a.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080632 Genomic DNA. Translation: CCD65323.1 .
    FO080632 Genomic DNA. Translation: CCD65324.1 .
    PIRi T25557.
    RefSeqi NP_001021978.1. NM_001026807.2.
    NP_001021979.1. NM_001026808.2.
    UniGenei Cel.8663.

    3D structure databases

    ProteinModelPortali P91079.
    SMRi P91079. Positions 76-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P91079. 1 interaction.
    MINTi MINT-213137.
    STRINGi 6239.C23H3.4a.2.

    Proteomic databases

    PaxDbi P91079.
    PRIDEi P91079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C23H3.4a.1 ; C23H3.4a.1 ; WBGene00016020 .
    C23H3.4a.2 ; C23H3.4a.2 ; WBGene00016020 .
    GeneIDi 173389.
    KEGGi cel:CELE_C23H3.4.
    UCSCi C23H3.4a.2. c. elegans.

    Organism-specific databases

    CTDi 173389.
    WormBasei C23H3.4a ; CE08323 ; WBGene00016020 ; sptl-1.
    C23H3.4b ; CE37749 ; WBGene00016020 ; sptl-1.

    Phylogenomic databases

    eggNOGi COG0156.
    GeneTreei ENSGT00550000074872.
    HOGENOMi HOG000216602.
    InParanoidi P91079.
    OMAi TEMAING.
    PhylomeDBi P91079.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_183003. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 879437.
    PROi P91079.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis."
      Zhang H., Abraham N., Khan L.A., Hall D.H., Fleming J.T., Gobel V.
      Nat. Cell Biol. 13:1189-1201(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSPTC1_CAEEL
    AccessioniPrimary (citable) accession number: P91079
    Secondary accession number(s): Q5R3Y5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3