Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine palmitoyltransferase 1

Gene

sptl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pathway:isphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • biosynthetic process Source: InterPro
  • establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
  • sphingolipid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_279993. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 1 (EC:2.3.1.50)
Alternative name(s):
Long chain base biosynthesis protein 1
Short name:
LCB 1
Serine-palmitoyl-CoA transferase 1
Short name:
SPT 1
Short name:
SPT1
Gene namesi
Name:sptl-1
ORF Names:C23H3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC23H3.4a; CE08323; WBGene00016020; sptl-1.
C23H3.4b; CE37749; WBGene00016020; sptl-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Serine palmitoyltransferase 1PRO_0000421271Add
BLAST

Proteomic databases

PaxDbiP91079.
PRIDEiP91079.

Interactioni

Subunit structurei

Heterodimer of sptl-1/sptl-2 or sptl-1/sptl-3.By similarity

Protein-protein interaction databases

BioGridi38769. 1 interaction.
IntActiP91079. 1 interaction.
MINTiMINT-213137.
STRINGi6239.C23H3.4a.3.

Structurei

3D structure databases

ProteinModelPortaliP91079.
SMRiP91079. Positions 76-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00550000074872.
HOGENOMiHOG000216602.
InParanoidiP91079.
KOiK00654.
OMAiPYKEITG.
PhylomeDBiP91079.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P91079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLPDSWHF YIETLLVALL AYVVMRNRSK RQQEKLSKKL TERQKDELIA
60 70 80 90 100
DWTPEPLVPE TPQDHPVLNP KYADGKMTKD VSIDGEKYLN MASTNFLSFI
110 120 130 140 150
GVKRIEDRAK QTIFKYGVGS CGPRGFYGTV DVHLDLEKEL AKFMGCEEAV
160 170 180 190 200
LYSYGFATVS SAIPAYAKKG DVIFVDEGVN FAIQKGLQAS RSRVEYFKHN
210 220 230 240 250
DMEHLERLLL EQEQRDKKDP KKAKSVRRFI VVEGLYVNYA DLCPLPKIIE
260 270 280 290 300
FKWRFKVRVF IDESWSFGVI GKTGRGVTEH FNVPMEDVDM VMASLENALA
310 320 330 340 350
STGGFCVGRS YVVGHQRLSG LGYCFSASLP PLLATAASEA ISIIDEEPSR
360 370 380 390 400
VQKVTEMAIN GQKKLQDALS GSKFSLQGCP ESPMKHIYYN GEDEEKQLDT
410 420 430 440 450
FVETVFTKNH LLLTRARYLD KDELFKIRPS IRVMFQHDLT EEEIQRAVDA

IRVVAHKF
Length:458
Mass (Da):52,085
Last modified:May 1, 1997 - v1
Checksum:i2F56AC94DFFABF91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080632 Genomic DNA. Translation: CCD65323.1.
FO080632 Genomic DNA. Translation: CCD65324.1.
PIRiT25557.
RefSeqiNP_001021978.1. NM_001026807.2.
NP_001021979.1. NM_001026808.2.
UniGeneiCel.8663.

Genome annotation databases

EnsemblMetazoaiC23H3.4a.1; C23H3.4a.1; WBGene00016020.
C23H3.4a.2; C23H3.4a.2; WBGene00016020.
GeneIDi173389.
KEGGicel:CELE_C23H3.4.
UCSCiC23H3.4a.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080632 Genomic DNA. Translation: CCD65323.1.
FO080632 Genomic DNA. Translation: CCD65324.1.
PIRiT25557.
RefSeqiNP_001021978.1. NM_001026807.2.
NP_001021979.1. NM_001026808.2.
UniGeneiCel.8663.

3D structure databases

ProteinModelPortaliP91079.
SMRiP91079. Positions 76-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38769. 1 interaction.
IntActiP91079. 1 interaction.
MINTiMINT-213137.
STRINGi6239.C23H3.4a.3.

Proteomic databases

PaxDbiP91079.
PRIDEiP91079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC23H3.4a.1; C23H3.4a.1; WBGene00016020.
C23H3.4a.2; C23H3.4a.2; WBGene00016020.
GeneIDi173389.
KEGGicel:CELE_C23H3.4.
UCSCiC23H3.4a.2. c. elegans.

Organism-specific databases

CTDi173389.
WormBaseiC23H3.4a; CE08323; WBGene00016020; sptl-1.
C23H3.4b; CE37749; WBGene00016020; sptl-1.

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00550000074872.
HOGENOMiHOG000216602.
InParanoidiP91079.
KOiK00654.
OMAiPYKEITG.
PhylomeDBiP91079.

Enzyme and pathway databases

UniPathwayiUPA00222.
ReactomeiREACT_279993. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi879437.
PROiP91079.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis."
    Zhang H., Abraham N., Khan L.A., Hall D.H., Fleming J.T., Gobel V.
    Nat. Cell Biol. 13:1189-1201(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSPTC1_CAEEL
AccessioniPrimary (citable) accession number: P91079
Secondary accession number(s): Q5R3Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.