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Reviewed, UniProtKB/Swiss-Prot P90986 (TY3H_CAEEL)

Last modified January 19, 2010. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine 3-monooxygenase
    EC=1.14.16.2
Alternative name(s):
    Tyrosine 3-hydroxylase
      Short name=TH
Gene names
Name: cat-2
ORF Names: B0432.5
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion.

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: P90986-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confimation available.
Isoform a (identifier: P90986-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFLRYMRRRGSGEDHEEEPRGVTVIATKVAENSKNPRRYSLVHQASCETQHHKGIRRQNTIQHRKQLTDQM
     324-454: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Tyrosine 3-monooxygenase
PRO_0000205565

Sites

Metal binding2821Iron By similarity
Metal binding2871Iron By similarity
Metal binding3271Iron By similarity

Natural variations

Alternative sequence11M → MFLRYMRRRGSGEDHEEEPR GVTVIATKVAENSKNPRRYS LVHQASCETQHHKGIRRQNT IQHRKQLTDQM in isoform a.
VSP_013645
Alternative sequence324 – 454131Missing in isoform a.
VSP_013646

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified May 10, 2005. Version 3.
Checksum: 1AC61E1D39DBB283

FASTA45451,313
        10         20         30         40         50         60 
MRCQKILQQL NDEGIEVIFT ANDVTPIEFS IILTSTDPTL SNFVSDILQN MSSAKVQICH 

        70         80         90        100        110        120 
VETRGNEASH DVLLACKATK NQLIHSAELL TQNHVALTKF SIFAKKLSDE KNQSQIWFPR 

       130        140        150        160        170        180 
HISELDQCSK CITKYEPTTD PRHPGHGDVA YIARRKFLND QALEFKFGDE IGYVDYTEEE 

       190        200        210        220        230        240 
HATWKAVYEK LGDLHLSHTC AVYRQNLKIL QEEKVLTADR IPQIRDVNKF LQKKTGFELR 

       250        260        270        280        290        300 
PCSGLLSARD FLASLAFRVF QTTTYLRHHK SPHHSPEPDL IHELLGHVPM FSDPLLAQMS 

       310        320        330        340        350        360 
QDIGLMSLGA SDEHIEKLST VYWFIVEFGL CKEDGKLKAI GAGLLSAYGE LMHACSDAPE 

       370        380        390        400        410        420 
HKDFDPAVTA VQKYEDDDYQ PLYFVADSIH DALAKLRKYA SSMDRPFSVV YDPFTKSIEA 

       430        440        450 
IESSADLEKA FSRLSNDLSA ITHAADRMKI SITM 

« Hide

Isoform a.

Checksum: EB3FFD8636D2D003
Show »

FASTA39345,123

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80836 Genomic DNA. Translation: AAV58889.1.
U80836 Genomic DNA. Translation: AAV58890.1.
PIRT25453.
RefSeqNP_493688.3.
NP_871903.2.
UniGeneCel.8024

3D structure databases

SMRP90986. Positions 116-448.
ModBaseSearch...

Protein-protein interaction databases

STRINGP90986.

Proteomic databases

PRIDEP90986.

Genome annotation databases

EnsemblB0432.5b; B0432.5b; B0432.5; Caenorhabditis elegans. [Genome view]
GeneID173411.
KEGGcel:B0432.5.
UCSCB0432.5a. c. elegans.

Organism-specific databases

CTD173411.
WormBaseWBGene00000296. cat-2.
WormPepB0432.5a. CE32103. [WorfDB]
B0432.5b. CE37742. [WorfDB]

Phylogenomic databases

eggNOGmeNOG04044.
HOGENOMHBG484724.
InParanoidP90986.
OMACSDAPEH.
PhylomeDBP90986.

Enzyme and pathway databases

BRENDA1.14.16.2. 672.

Gene expression databases

ArrayExpressP90986.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
PROSITEPS00367. BIOPTERIN_HYDROXYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio879535.

Entry information

Entry nameTY3H_CAEEL
AccessionPrimary (citable) accession number: P90986
Secondary accession number(s): Q5R3Y3, Q5R3Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2005
Last modified: January 19, 2010
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents