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Protein

Protein kinase C-like 2

Gene

pkc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei377ATPPROSITE-ProRule annotation1
Active sitei472Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 88Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri103 – 153Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi354 – 362ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-dependent protein kinase C activity Source: WormBase
  • protein kinase C activity Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • peptidyl-serine phosphorylation Source: WormBase
  • peptidyl-threonine phosphorylation Source: WormBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-111933 Calmodulin induced events
R-CEL-114516 Disinhibition of SNARE formation
R-CEL-1169091 Activation of NF-kappaB in B cells
R-CEL-2179392 EGFR Transactivation by Gastrin
R-CEL-3000170 Syndecan interactions
R-CEL-399997 Acetylcholine regulates insulin secretion
R-CEL-4419969 Depolymerisation of the Nuclear Lamina
R-CEL-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-CEL-5099900 WNT5A-dependent internalization of FZD4
R-CEL-5218921 VEGFR2 mediated cell proliferation
R-CEL-76005 Response to elevated platelet cytosolic Ca2+
SignaLinkiP90980

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like 2 (EC:2.7.11.13)
Short name:
PKC2
Gene namesi
Name:pkc-2
Synonyms:kin-11
ORF Names:E01H11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiE01H11.1a ; CE30927 ; WBGene00004033 ; pkc-2
E01H11.1b ; CE30928 ; WBGene00004033 ; pkc-2
E01H11.1c ; CE30929 ; WBGene00004033 ; pkc-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557361 – 682Protein kinase C-like 2Add BLAST682

Proteomic databases

EPDiP90980
PaxDbiP90980
PeptideAtlasiP90980
PRIDEiP90980

Expressioni

Gene expression databases

BgeeiWBGene00004033
ExpressionAtlasiP90980 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi46082, 7 interactors
DIPiDIP-24386N
STRINGi6239.E01H11.1c

Structurei

3D structure databases

ProteinModelPortaliP90980
SMRiP90980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 263C2PROSITE-ProRule annotationAdd BLAST104
Domaini348 – 609Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini610 – 681AGC-kinase C-terminalAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 88Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri103 – 153Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00820000126964
HOGENOMiHOG000233022
InParanoidiP90980
OMAiSSLNPCW
OrthoDBiEOG091G0QRS
PhylomeDBiP90980

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR014375 Protein_kinase_C_a/b/g
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000550 PKC_alpha, 1 hit
PRINTSiPR00360 C2DOMAIN
PR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50004 C2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: P90980-1) [UniParc]FASTAAdd to basket
Also known as: PKC2B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSTNSSVK EDEAQRIEGK AFVRRGALRQ KNVHEIKSHK FIARFFKQPT
60 70 80 90 100
FCSHCKDFLW GITKQGFQCQ VCTLVVHKRC HEFVNFACPG ADKGVDTDDP
110 120 130 140 150
RQQHKWKVQT YSSPTFCDHC GSLLYGILHQ GMKCQSCDTN VHHRCVKNVP
160 170 180 190 200
NMCGTDNTEK RGRLRIEAHI ENDQLTIKIL EAKNLIPMDP NGLSDPYVKC
210 220 230 240 250
KLIPEDSGCK SKQKTKTLRA TLNPQWNETF TYKLLPGDKD RRLSIEVWDW
260 270 280 290 300
DRTSRNDFMG SLSFGISELM KEAASGWYKL LSAEEGEFYN INITPEYDED
310 320 330 340 350
MEKVRKKMNE NFITRDNSSS KPKDPAAPRA STLPLGSSNH NVIKASDFNF
360 370 380 390 400
LTVLGKGSFG KVLLGEQKTT KELFAIKVLK KDVIIQDDDV ECTMTEKRVL
410 420 430 440 450
ALPEKPSFLV ALHSCFQTMD RLYFVMEFVN GGDLMYQIQQ VGKFKEPVAV
460 470 480 490 500
FYAAEIAVGL FFLHSKGIIY RDLKLDNVML ERDGHIKITD FGMCKENIFG
510 520 530 540 550
DATTKTFCGT PDYIAPEIIL YQPYGKSVDW WAYGVLLFEM LAGQPPFDGE
560 570 580 590 600
DEDELFTAIT EHNVSYPKSL SKEAVSLCKA LLIKNPSKRL GCTGDDESAS
610 620 630 640 650
RDIKEHPFFR RIDWFKIETR QIQPPFKPKL KTDRSTENFD HSFLKLPTKM
660 670 680
TPPDWEVLEN LKGDEFSNFS FVNPFYVKDV EP
Length:682
Mass (Da):78,000
Last modified:February 16, 2004 - v2
Checksum:iE41C5C12DA38ED3C
GO
Isoform a (identifier: P90980-2) [UniParc]FASTAAdd to basket
Also known as: PKC2A

The sequence of this isoform differs from the canonical sequence as follows:
     632-682: TDRSTENFDH...NPFYVKDVEP → SADDTSNFDS...FVNPEYVQEC

Show »
Length:680
Mass (Da):77,695
Checksum:i6CD177A781ED16C8
GO
Isoform c (identifier: P90980-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSLSTNSSVKEDE → MSLRPKQKSS...RPLLKRLHEQ
     682-682: P → PHIFYVLFIF...FVNPEYVQEC

Note: No experimental confirmation available.
Show »
Length:936
Mass (Da):106,866
Checksum:i08B90BDED607DBF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200C → W in AAB40868 (PubMed:9045693).Curated1
Sequence conflicti200C → W in AAB40869 (PubMed:9045693).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093691 – 13MSLST…VKEDE → MSLRPKQKSSSTSVFLKSHK FSLTSHILRKAKKRETMDSA ERRRSETDIGGGPRNSADAR PSLDLSSDPMLESNLALRKL SEAFAAAALISPVKNNSTGG GGNQQLCIRKSISNPSSLKV YAHHEAPGIIHFPRFEFSHR LSIRPLLKRLHEQ in isoform c. CuratedAdd BLAST13
Alternative sequenceiVSP_009370632 – 682TDRST…KDVEP → SADDTSNFDSEFTHEVPKLT PIDRLFLMNLDQTEFEGFSF VNPEYVQEC in isoform a. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_009371682P → PHIFYVLFIFLILRPFLLLP YLSHLQLTLSAIHSPLLLLS ASVFFKFLFKNNFSQSPYNK IKVLLKSADDTSNFDSEFTH EVPKLTPIDRLFLMNLDQTE FEGFSFVNPEYVQEC in isoform c. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82935 mRNA Translation: AAB40868.1
U82936 mRNA Translation: AAB40869.1
FO080629 Genomic DNA Translation: CCD65287.1
FO080629 Genomic DNA Translation: CCD65288.1
FO080629 Genomic DNA Translation: CCD65289.1
PIRiT15902
RefSeqiNP_001024516.1, NM_001029345.3
NP_001024517.1, NM_001029346.2 [P90980-1]
NP_001024518.1, NM_001029347.1 [P90980-3]
UniGeneiCel.667

Genome annotation databases

EnsemblMetazoaiE01H11.1b; E01H11.1b; WBGene00004033 [P90980-1]
GeneIDi181166
UCSCiE01H11.1d c. elegans [P90980-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKPC2_CAEEL
AccessioniPrimary (citable) accession number: P90980
Secondary accession number(s): P90981
, Q19024, Q8MQ87, Q8MQ88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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