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Protein
Submitted name:

LIN-7

Gene
N/A
Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-CEL-212676. Dopamine Neurotransmitter Release Cycle.
R-CEL-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Submitted name:
LIN-7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

PTM / Processingi

Proteomic databases

EPDiP90976.
PaxDbiP90976.

Expressioni

Gene expression databases

ExpressionAtlasiP90976. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
csc-1O459522EBI-2918984,EBI-328477

Protein-protein interaction databases

IntActiP90976. 12 interactions.
MINTiMINT-117496.
STRINGi6239.Y54G11A.10a.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL8NMR-A116-165[»]
ProteinModelPortaliP90976.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP90976.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 17256L27InterPro annotationAdd
BLAST
Domaini200 – 28182PDZ (DHR)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3550. Eukaryota.
ENOG410XP5T. LUCA.
HOGENOMiHOG000285929.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR014775. L27_C.
IPR004172. L27_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P90976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKGFTGSF QQIRGLLRPP KNLPFRGIFR KDGEVVRKDD LLVNQFKMNY
60 70 80 90 100
HPGLNVYYEN DRGERLLRAH CDGIVRISQE KCDPDYEIEE MKGYEYRKDV
110 120 130 140 150
DLYKMTFNMD NPDGPNLERD VQRILELMEH VQKTGEVNNA KLASLQQVLQ
160 170 180 190 200
SEFFGAVREV YETVYESIDA DTTPEIKAAA TAKATVAAFA AAEGHAHPRI
210 220 230 240 250
VELPKTDQGL GFNVMGGKEQ NSPIYISRII PGGVADRHGG LKRGDQLIAV
260 270 280 290
NGNVEAECHE KAVDLLKSAV GSVKLVIRYM PKLLDEMERR FERQRIP
Length:297
Mass (Da):33,580
Last modified:May 1, 1997 - v1
Checksum:iA8F15EDB90B0A90E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei297 – 2971Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78092 mRNA. Translation: AAB36684.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78092 mRNA. Translation: AAB36684.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL8NMR-A116-165[»]
ProteinModelPortaliP90976.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP90976. 12 interactions.
MINTiMINT-117496.
STRINGi6239.Y54G11A.10a.

Proteomic databases

EPDiP90976.
PaxDbiP90976.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3550. Eukaryota.
ENOG410XP5T. LUCA.
HOGENOMiHOG000285929.

Enzyme and pathway databases

ReactomeiR-CEL-212676. Dopamine Neurotransmitter Release Cycle.
R-CEL-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

EvolutionaryTraceiP90976.

Gene expression databases

ExpressionAtlasiP90976. baseline.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR014775. L27_C.
IPR004172. L27_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction."
    Simske J.S., Kaech S.M., Harp S.A., Kim S.K.
    Cell 85:195-204(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes."
    Petrosky K.Y., Ou H.D., Lohr F., Dotsch V., Lim W.A.
    J. Biol. Chem. 280:38528-38536(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 116-165.

Entry informationi

Entry nameiP90976_CAEEL
AccessioniPrimary (citable) accession number: P90976
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: April 13, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.