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Protein

Alpha-catenin-like protein hmp-1

Gene

hmp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Required for proper localization of other junctional components, such as pac-1 (PubMed:25938815).2 Publications

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • beta-catenin binding Source: WormBase
  • cadherin binding Source: InterPro

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell migration Source: WormBase
  • cell migration involved in gastrulation Source: WormBase
  • cytoskeletal anchoring at plasma membrane Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • regulation of actin cytoskeleton organization Source: WormBase
  • regulation of protein localization Source: WormBase

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-CEL-5218920. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-catenin-like protein hmp-1Curated
Alternative name(s):
Protein humpback-1Imported
Gene namesi
Name:hmp-1
ORF Names:R13H4.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiR13H4.4a; CE25089; WBGene00001978; hmp-1.

Subcellular locationi

GO - Cellular componenti

  • apical junction complex Source: WormBase
  • catenin complex Source: WormBase
  • cell-cell adherens junction Source: WormBase
  • cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Worms arrest their elongation at the 1.25X to 1.5X stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686481 – 927Alpha-catenin-like protein hmp-1CuratedAdd BLAST927

Proteomic databases

EPDiP90947.
PaxDbiP90947.
PRIDEiP90947.

Expressioni

Tissue specificityi

Epidermal cells.1 Publication

Developmental stagei

Present in all embryonic blastomeres at early stages of development.2 Publications

Gene expression databases

BgeeiWBGene00001978.
ExpressionAtlasiP90947. baseline.

Interactioni

Subunit structurei

Component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (Probable). May interact with hmp-2 (PubMed:11560894).Curated1 Publication

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • beta-catenin binding Source: WormBase
  • cadherin binding Source: InterPro

Protein-protein interaction databases

BioGridi44648. 1 interactor.
DIPiDIP-61638N.
STRINGi6239.R13H4.4b.

Structurei

Secondary structure

1927
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi271 – 282Combined sources12
Turni287 – 289Combined sources3
Helixi292 – 314Combined sources23
Helixi321 – 345Combined sources25
Helixi357 – 387Combined sources31
Helixi393 – 402Combined sources10
Turni403 – 405Combined sources3
Helixi407 – 431Combined sources25
Helixi432 – 434Combined sources3
Helixi438 – 467Combined sources30
Helixi472 – 498Combined sources27
Helixi502 – 525Combined sources24
Helixi541 – 565Combined sources25
Helixi570 – 584Combined sources15
Helixi586 – 604Combined sources19
Helixi605 – 607Combined sources3
Helixi610 – 639Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H5MX-ray2.40A/B267-646[»]
ProteinModelPortaliP90947.
SMRiP90947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili319 – 354Sequence analysisAdd BLAST36
Coiled coili672 – 696Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000280724.
InParanoidiP90947.

Family and domain databases

InterProiView protein in InterPro
IPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
PANTHERiPTHR18914. PTHR18914. 1 hit.
PfamiView protein in Pfam
PF01044. Vinculin. 2 hits.
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.

Sequencei

Sequence statusi: Complete.

P90947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANGNSHAY FNIDEVRSKN VLKQITQLIN EVTNITETFP LKPGQTTEGL
60 70 80 90 100
VATLDAAVAN FLQTGSFAIS KCPIANSDPR AIDLLHEALG AVQDTGQVMI
110 120 130 140 150
QTGRDFVRDS TSTNKRAIAT NSGRNLLTAV AKFLILADSI DVKVIVDKVD
160 170 180 190 200
EVRETAHQMI EADTKIKVDD LYNLLISQIE ELDITVRRRA IDLVKPNQRD
210 220 230 240 250
DLLAARSALR QTAPLLYTST RTFVRHPEHE EARRNRDYTA DEMHSALNAL
260 270 280 290 300
ESVLNGQQPK VTFSEYGRIG DLINEIDTFQ NRIEIDPAHY RRGTDRPDLE
310 320 330 340 350
GHCERIVSGS ASIADAESTR ENRKQKIVAE CNNLRQALQE LLTEYEKSTG
360 370 380 390 400
RRDDNDDIPL GIAEVHKRTK DLRRHLRRAI VDHISDAFLD TRTPLILLIE
410 420 430 440 450
AAKEGHEENT RYRSKMFQEH ANEIVSVARL SCQLSSDVES VSVIQHTAAQ
460 470 480 490 500
LEKLAPQVAQ AAILLCHQPT SKTAQENMET YKNAWFDKVR LLTTALDNIT
510 520 530 540 550
TLDDFLAVSE AHIVEDCERG IKGITANAST PDENAANCET VDCAAGSIRG
560 570 580 590 600
RALRVCDVVD AEMDFLQNSE YTETVKQAVR ILKTQRVDQF AERASALANR
610 620 630 640 650
QEAHGLTWDP KTKEEEMNEF INACTLVHDA VKDIRHALLM NRSMNDVDSD
660 670 680 690 700
VEYEADGVGA ANADANRTIS EQENQQNLMR RLPEEEKKKI QAQIDIFKVT
710 720 730 740 750
QTRFEREVAK WDETGNDIIS LANNMCKIMM SMTEFTRGCG PLKTTMDVIR
760 770 780 790 800
AAQEISLNGS KLNALARQIG EESADSQTKK DLLAYLSQIT LYCQQLNICS
810 820 830 840 850
KVKADVTQVG NELVVSALDS AMSLIQTARN LLTAVVQTVK AAYIASTKFR
860 870 880 890 900
RPNANSVRVE WRMAPPKKQP LIRPQKNNAI IRRASERRPL QPAKVLAEFT
910 920
RNEIETGRDS DDEELDRRHQ QRINGRL
Length:927
Mass (Da):103,994
Last modified:May 1, 2000 - v2
Checksum:i8F3DCB97613B88AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016852 mRNA. Translation: AAB94551.1.
Z81579 Genomic DNA. Translation: CAB61019.1.
RefSeqiNP_505985.1. NM_073584.4.
UniGeneiCel.22869.

Genome annotation databases

EnsemblMetazoaiR13H4.4a; R13H4.4a; WBGene00001978.
GeneIDi179624.
UCSCiR13H4.4a. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHMP1_CAEEL
AccessioniPrimary (citable) accession number: P90947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families