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Protein
Submitted name:

Uncharacterized protein

Gene

madd-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • metallopeptidase activity Source: InterPro
  • receptor binding Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • dorsal/ventral axon guidance Source: WormBase
  • synapse organization Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:madd-4Imported
ORF Names:CELE_F53B6.2Imported, F53B6.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF53B6.2a; CE36859; WBGene00009958; madd-4.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: WormBase
  • proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 10451022Sequence analysisPRO_5004161775Add
BLAST

Proteomic databases

PaxDbiP90884.

Expressioni

Gene expression databases

ExpressionAtlasiP90884. baseline and differential.

Interactioni

GO - Molecular functioni

  • receptor binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F53B6.2a.

Structurei

3D structure databases

ProteinModelPortaliP90884.
SMRiP90884. Positions 26-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini637 – 73296Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini1004 – 104138PLACInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410INDC. Eukaryota.
ENOG410YY5R. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000019636.
InParanoidiP90884.
OMAiKLPDKEC.
OrthoDBiEOG7DJSM0.
PhylomeDBiP90884.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 9 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF82895. SSF82895. 9 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCSYTVVFL LFYLLIASFH VDALSWAAWS PWSSCTKTCG GGVSRQLRRC
60 70 80 90 100
LTSKCSGESV RFKVCAQKTC ESKSRLARDT ICGGEEIVSR GQCEVVCRSR
110 120 130 140 150
LTGANFLWRV DDGTPCQAAT SRAVCSKGSC QIVGCDGLIS SSFRFDACGV
160 170 180 190 200
CGGRGDTCDN GKFIWKVSEE YTACASNCDD IVDWSGAGRS IASTSQPIVV
210 220 230 240 250
CVNAITGRVV PEKLCADKLR PKVEARPCPM LICPSRCRWM AADWTECVPH
260 270 280 290 300
CGEGTRKREV YCVQTAHNVT VHVPDTFCEN GTRPAAEENC VSTSCGRWEA
310 320 330 340 350
GKWSKCTASC GQGVRRRHVA CVGGSDCDEG GRPRQETTCY AGIPCSIATN
360 370 380 390 400
SLDWNDRAYL DGNTFGSMDN HNDWQAPRLV AGEWSTCSST CGTGVMSRTV
410 420 430 440 450
ECVAVNPISS APIKLPMSEC QDQEQPKLFE SCEVRSCPLQ EDSKLSEDEA
460 470 480 490 500
PYQWRYGDWT QCSASCLGGK QKAALKCIQV STGKSVQWSQ CDARRRPPEK
510 520 530 540 550
SRPCNQHPCP PFWLTSKYSD CSMSCGSGTA RRSVKCAQTV SKTDGADAHI
560 570 580 590 600
VLRDDRCHFK KPQETETCNV VACPATWVTA QWTECSRSCD SGERRRQVWC
610 620 630 640 650
EIRDSRGKTQ RRPDVECDAN TKPQTVEVCS FGSCSRPELL SNRVFEQNAE
660 670 680 690 700
QKKLTLGIGG VATLYQGTSI KIKCPAKKFD KKKIYWKKNG KKIKNDAHIK
710 720 730 740 750
VSANGNLRVF HARMEDAGVY ECFTDRLQGN VTLNFKYRDF PASRVDLAPK
760 770 780 790 800
PQIPSTKNRQ RVQVSKEDVL REQASVLHKM NVSLIEALLT APNDEKAREQ
810 820 830 840 850
LRKYGNELVA RWDIGHWSEC RQKTCHVAGY QARGISCKVT FHGEIRNVDN
860 870 880 890 900
SICESLASVR PPETRPCHRE DCPRWEASQW SECSSQRCVS SMLAQKRRNV
910 920 930 940 950
TCRFTNGTSV DIQHCDITNR PATTMDCPNQ NCKAEWRTSD WGSCSSECGT
960 970 980 990 1000
GGVQLRLLSC VWISSGRPAG RNCEQMRRPH SARACVADEP LPPCMPTASA
1010 1020 1030 1040
LYQRDASCQD QSRFCDIIKL FHSCDSLEVR QKCCSTCTFV ERKKF
Length:1,045
Mass (Da):116,125
Last modified:September 13, 2004 - v5
Checksum:iF78269D1D50228B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB03121.3.
PIRiT22545.
RefSeqiNP_492405.3. NM_060004.4.
UniGeneiCel.5959.

Genome annotation databases

EnsemblMetazoaiF53B6.2a; F53B6.2a; WBGene00009958.
GeneIDi172706.
UCSCiF53B6.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB03121.3.
PIRiT22545.
RefSeqiNP_492405.3. NM_060004.4.
UniGeneiCel.5959.

3D structure databases

ProteinModelPortaliP90884.
SMRiP90884. Positions 26-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F53B6.2a.

Proteomic databases

PaxDbiP90884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF53B6.2a; F53B6.2a; WBGene00009958.
GeneIDi172706.
UCSCiF53B6.2b. c. elegans.

Organism-specific databases

CTDi172706.
WormBaseiF53B6.2a; CE36859; WBGene00009958; madd-4.

Phylogenomic databases

eggNOGiENOG410INDC. Eukaryota.
ENOG410YY5R. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000019636.
InParanoidiP90884.
OMAiKLPDKEC.
OrthoDBiEOG7DJSM0.
PhylomeDBiP90884.

Enzyme and pathway databases

ReactomeiR-CEL-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

NextBioi876671.

Gene expression databases

ExpressionAtlasiP90884. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 9 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF82895. SSF82895. 9 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP90884_CAEEL
AccessioniPrimary (citable) accession number: P90884
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 113 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.