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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-44

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-44Imported
ORF Names:CELE_F46F3.2Imported, F46F3.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF46F3.2; CE31948; WBGene00009790; lgc-44.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei522 – 54423HelicalSequence analysisAdd
BLAST
Transmembranei590 – 60819HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 618598Sequence analysisPRO_5004161869Add
BLAST

Proteomic databases

PaxDbiP90876.
PRIDEiP90876.

Interactioni

Protein-protein interaction databases

STRINGi6239.F46F3.2.

Structurei

3D structure databases

ProteinModelPortaliP90876.
SMRiP90876. Positions 259-603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini257 – 426170Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini464 – 55087Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000022498.
InParanoidiP90876.
KOiK05397.
OMAiHIANTYI.
OrthoDBiEOG712TVZ.
PhylomeDBiP90876.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.

Sequencei

Sequence statusi: Complete.

P90876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLISISLL FLIFPHSSNP SSSNFLDIAS TYQAVDYGIA TDQHQQCLSW
60 70 80 90 100
KLWWKTQKSL HDPSTADIDL LAIRRAEVWI RNEHDAEKYD VPVELLQNFT
110 120 130 140 150
TIRIVFRNVC RLLPRVLQIS SPLAARRSRI TLDALCQTYN YSDPEVQELV
160 170 180 190 200
LNNYEEAQEN AIGIDQLLFL DHQSVMIVMP AACNSSNSDE KEISKQYYLE
210 220 230 240 250
KYGDFSFNVS NLNIELDKLH EMVHDFKPLD QIMNQNLGLD YQRPLPSSTI
260 270 280 290 300
LPFLRKMEYD ARQPPSLHVD DTVTVKVGIA VQSMSNFELS TMDYDLDAWV
310 320 330 340 350
RMSWIDPRLR HDLSRPILVN DYTFLKMIWR PDPIFTNSKY STFHKVTYLN
360 370 380 390 400
FYLFIFPDGK IFMDMRVYLK PTAAQIVLCK YPHDNPAVSL KISSMGFTQD
410 420 430 440 450
VVKLEWFSDT NDAIWIEKNV KIPELSIRHL HPDTCNGVRK SGVYSCLEAK
460 470 480 490 500
FYMHREVGYH IANTYIPTAI CVVFSWISVW LPEEFVEGRI FVSLTVFLTL
510 520 530 540 550
SAENNSAKEE LPKVSYVKAI DIWFGFTSTF VFLTMLQALV VISLEHNSKR
560 570 580 590 600
LRLKFENNLD GYSKYQMTKS MLLSRYYHRM ARQIDTFCKV MYPVIFLLFL
610
MFYVFVITQG DERKCIKN
Length:618
Mass (Da):72,018
Last modified:March 1, 2003 - v3
Checksum:i5C63CD60BE1AD34E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB03114.2.
PIRiT22315.
RefSeqiNP_505954.2. NM_073553.4.
UniGeneiCel.3540.

Genome annotation databases

EnsemblMetazoaiF46F3.2; F46F3.2; WBGene00009790.
GeneIDi179600.
KEGGicel:CELE_F46F3.2.
UCSCiF46F3.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB03114.2.
PIRiT22315.
RefSeqiNP_505954.2. NM_073553.4.
UniGeneiCel.3540.

3D structure databases

ProteinModelPortaliP90876.
SMRiP90876. Positions 259-603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F46F3.2.

Proteomic databases

PaxDbiP90876.
PRIDEiP90876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF46F3.2; F46F3.2; WBGene00009790.
GeneIDi179600.
KEGGicel:CELE_F46F3.2.
UCSCiF46F3.2. c. elegans.

Organism-specific databases

CTDi179600.
WormBaseiF46F3.2; CE31948; WBGene00009790; lgc-44.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000022498.
InParanoidiP90876.
KOiK05397.
OMAiHIANTYI.
OrthoDBiEOG712TVZ.
PhylomeDBiP90876.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP90876_CAEEL
AccessioniPrimary (citable) accession number: P90876
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.