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Protein

Proteasome subunit beta

Gene

pbs-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:pbs-7Imported
ORF Names:CELE_F39H11.5Imported, F39H11.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF39H11.5 ; CE20761 ; WBGene00003953 ; pbs-7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, ProteasomeImported

PTM / Processingi

Proteomic databases

EPDiP90868
PaxDbiP90868
PeptideAtlasiP90868

Expressioni

Gene expression databases

BgeeiWBGene00003953

Interactioni

Protein-protein interaction databases

DIPiDIP-26967N
IntActiP90868, 8 interactors
STRINGi6239.F39H11.5

Structurei

3D structure databases

ProteinModelPortaliP90868
SMRiP90868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0185 Eukaryota
ENOG410YAMA LUCA
GeneTreeiENSGT00390000000698
HOGENOMiHOG000181719
InParanoidiP90868
KOiK02736
OMAiKECMKVL
OrthoDBiEOG091G0JV7
PhylomeDBiP90868

Family and domain databases

CDDicd03760 proteasome_beta_type_4, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR016295 Proteasome_endopept_cplx_B
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF5 PTHR11599:SF5, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF001213 Psome_endopept_beta, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

Sequencei

Sequence statusi: Complete.

P90868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAHDEVQRT LNPTCTGTSV IALQYKTGVV VLTDRVVSYG KMARYKNVSR
60 70 80 90 100
QYKVNDNVLI AFGGDHADFH WLQNVIERQV LLWKRFDQDI GPKALHGYLT
110 120 130 140 150
SLLYAKRCKM NPVWNTLVVA GVEEEEKNNK ETSTPFIGVI TQKGCAYQVK
160 170 180 190 200
HIATGLGAFL LNQAVEDEWR KKGEDLSREE AEAVLRKSLE LTLYHDCVAD
210 220 230
NEFEIGRVDA TEGVVLGKEE KIIGDWSIAE TNCQYE
Length:236
Mass (Da):26,682
Last modified:May 1, 1999 - v2
Checksum:iCFA2C116C799DABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03081.1
PIRiT22003
RefSeqiNP_492354.1, NM_059953.4
UniGeneiCel.18394

Genome annotation databases

EnsemblMetazoaiF39H11.5; F39H11.5; WBGene00003953
GeneIDi172674
KEGGicel:CELE_F39H11.5
UCSCiF39H11.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiP90868_CAEEL
AccessioniPrimary (citable) accession number: P90868
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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