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Protein

Uncharacterized peptidase C1-like protein F26E4.3

Gene

F26E4.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized peptidase C1-like protein F26E4.3
Gene namesi
ORF Names:F26E4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26E4.3; CE42101; WBGene00009158.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 452432Uncharacterized peptidase C1-like protein F26E4.3PRO_0000250555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 46AlternatePROSITE-ProRule annotation
Disulfide bondi46 ↔ 80AlternatePROSITE-ProRule annotation
Disulfide bondi56 ↔ 73AlternatePROSITE-ProRule annotation
Disulfide bondi56 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi62 ↔ 72PROSITE-ProRule annotation
Disulfide bondi73 ↔ 80AlternatePROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP90850.
PaxDbiP90850.

Interactioni

Protein-protein interaction databases

STRINGi6239.F26E4.3.1.

Structurei

3D structure databases

ProteinModelPortaliP90850.
SMRiP90850. Positions 184-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 8552SMBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi435 – 4384Poly-Arg

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Contains 1 SMB (somatomedin-B) domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1544. Eukaryota.
ENOG410YN9K. LUCA.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
InParanoidiP90850.
OMAiDNCNECR.
OrthoDBiEOG7SV0V1.
PhylomeDBiP90850.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS50958. SMB_2. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P90850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNSVFLLP VLCLIVPIYS RGFFGIPGDY CSVRTHTCCE NRDDDCTVPI
60 70 80 90 100
LGDHLCYCDM FCDRGPDGGN DCCPDFEATC RGKDIQNDQR IDGESCSMDG
110 120 130 140 150
DTKEKNCEKC TCHNGFWKCD GTACLIQPDI LEKIHTGRYS WSARNYSAFW
160 170 180 190 200
GRSLSDGIKY RLGTLFPERS VQNMNEILIK PRELPEHFDA RDKWGPLIHP
210 220 230 240 250
VADQGDCGSS WSVSTTAISS DRLAIISEGR INSTLSSQQL LSCNQHRQKG
260 270 280 290 300
CEGGYLDRAW WYIRKLGVVG DHCYPYVSGQ SREPGHCLIP KRDYTNRQGL
310 320 330 340 350
RCPSGSQDST AFKMTPPYKV SSREEDIQTE LMTNGPVQAT FVVHEDFFMY
360 370 380 390 400
AGGVYQHSDL AAQKGASSVA EGYHSVRVLG WGVDHSTGKP IKYWLCANSW
410 420 430 440 450
GTQWGEDGYF KVLRGENHCE IESFVIGAWG KGSKRRRRFK MRKLRRFRKM

FK
Length:452
Mass (Da):51,121
Last modified:September 2, 2008 - v3
Checksum:i9B6710E2E43E3EEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81070 Genomic DNA. Translation: CAB03007.2.
PIRiT21421.
RefSeqiNP_492593.2. NM_060192.6.
UniGeneiCel.18870.

Genome annotation databases

EnsemblMetazoaiF26E4.3.1; F26E4.3.1; WBGene00009158.
F26E4.3.2; F26E4.3.2; WBGene00009158.
GeneIDi172827.
KEGGicel:CELE_F26E4.3.
UCSCiF26E4.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81070 Genomic DNA. Translation: CAB03007.2.
PIRiT21421.
RefSeqiNP_492593.2. NM_060192.6.
UniGeneiCel.18870.

3D structure databases

ProteinModelPortaliP90850.
SMRiP90850. Positions 184-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F26E4.3.1.

Proteomic databases

EPDiP90850.
PaxDbiP90850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26E4.3.1; F26E4.3.1; WBGene00009158.
F26E4.3.2; F26E4.3.2; WBGene00009158.
GeneIDi172827.
KEGGicel:CELE_F26E4.3.
UCSCiF26E4.3.1. c. elegans.

Organism-specific databases

CTDi172827.
WormBaseiF26E4.3; CE42101; WBGene00009158.

Phylogenomic databases

eggNOGiKOG1544. Eukaryota.
ENOG410YN9K. LUCA.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
InParanoidiP90850.
OMAiDNCNECR.
OrthoDBiEOG7SV0V1.
PhylomeDBiP90850.

Miscellaneous databases

PROiP90850.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS50958. SMB_2. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  3. "Identification of the hydrophobic glycoproteins of Caenorhabditis elegans."
    Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.
    Glycobiology 15:952-964(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiYCF2E_CAEEL
AccessioniPrimary (citable) accession number: P90850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Although strongly related to peptidase C1 family, it lacks the conserved active Cys in position 210, which is replaced by a Ser residue, suggesting that it has no protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.