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P90795 (GPDM_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Short name=GPD-M
Short name=GPDH-M
EC=1.1.5.3
Gene names
ORF Names:T25G3.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length722 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD By similarity.

Enzyme regulation

Calcium-binding enhances the activity of the enzyme By similarity.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Mitochondrion
Chain44 – 722679Probable glycerol-3-phosphate dehydrogenase, mitochondrial
PRO_0000010432

Regions

Domain624 – 65936EF-hand 1
Domain660 – 69536EF-hand 2
Nucleotide binding76 – 10429FAD Potential
Calcium binding673 – 68412 Potential

Sequences

Sequence LengthMass (Da)Tools
P90795 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 9E8BF74246480E30

FASTA72280,807
        10         20         30         40         50         60 
MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE LNKRAPSALP 

        70         80         90        100        110        120 
TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT ALVELDDFSS GTSSRSTKLI 

       130        140        150        160        170        180 
HGGVRYLQAA IMKLDLEQYR MVKEALFERH NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS 

       190        200        210        220        230        240 
GIKAYDFVSG KRVLKNSFFI NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT 

       250        260        270        280        290        300 
AIRHGAACAN HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM 

       310        320        330        340        350        360 
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM TIAGTTDAPS 

       370        380        390        400        410        420 
DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS GLRPLVRDPN KKDTKSLARN 

       430        440        450        460        470        480 
HIIEVGKSGL ITIAGGKWTT YRHMAEETVD RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL 

       490        500        510        520        530        540 
QYIHLVQDYG MEVDVAQHLS NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR 

       550        560        570        580        590        600 
YAVREYACTA IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF 

       610        620        630        640        650        660 
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR KHFREHNQKI 

       670        680        690        700        710        720 
DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN RLVGYLDEIH GTPSVNRACG 


GI 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
PIRT20362.
RefSeqNP_492115.1. NM_059714.4.
UniGeneCel.38689.

3D structure databases

ProteinModelPortalP90795.
SMRP90795. Positions 73-590, 597-691.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T25G3.4.

Proteomic databases

PaxDbP90795.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT25G3.4.1; T25G3.4.1; T25G3.4.
T25G3.4.2; T25G3.4.2; T25G3.4.
GeneID172509.
KEGGcel:CELE_T25G3.4.
UCSCT25G3.4. c. elegans.

Organism-specific databases

CTD172509.
WormBaseT25G3.4; CE14180; WBGene00012031.

Phylogenomic databases

eggNOGCOG0578.
HOGENOMHOG000004813.
InParanoidP90795.
KOK00111.
OMASYFLTKS.
PhylomeDBP90795.

Enzyme and pathway databases

UniPathwayUPA00618; UER00673.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio875825.
PROP90795.

Entry information

Entry nameGPDM_CAEEL
AccessionPrimary (citable) accession number: P90795
Secondary accession number(s): Q22793
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase