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P90795

- GPDM_CAEEL

UniProt

P90795 - GPDM_CAEEL

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Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

T25G3.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Enzyme regulationi

Calcium-binding enhances the activity of the enzyme.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 10429FADSequence AnalysisAdd
BLAST
Calcium bindingi673 – 68412PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_255835. Fatty acid, triacylglycerol, and ketone body metabolism.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:T25G3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT25G3.4; CE14180; WBGene00012031.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343MitochondrionAdd
BLAST
Chaini44 – 722679Probable glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000010432Add
BLAST

Proteomic databases

PaxDbiP90795.

Interactioni

Protein-protein interaction databases

STRINGi6239.T25G3.4.

Structurei

3D structure databases

ProteinModelPortaliP90795.
SMRiP90795. Positions 73-590, 621-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini624 – 65936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini660 – 69536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
InParanoidiP90795.
KOiK00111.
OMAiKHLTESY.
PhylomeDBiP90795.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P90795-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE
60 70 80 90 100
LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT
110 120 130 140 150
ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH
160 170 180 190 200
NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI
210 220 230 240 250
NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN
260 270 280 290 300
HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM
310 320 330 340 350
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM
360 370 380 390 400
TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS
410 420 430 440 450
GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD
460 470 480 490 500
RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS
510 520 530 540 550
NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA
560 570 580 590 600
IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF
610 620 630 640 650
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR
660 670 680 690 700
KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN
710 720
RLVGYLDEIH GTPSVNRACG GI
Length:722
Mass (Da):80,807
Last modified:November 1, 1998 - v2
Checksum:i9E8BF74246480E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
PIRiT20362.
RefSeqiNP_492115.1. NM_059714.4.
UniGeneiCel.38689.

Genome annotation databases

EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031.
GeneIDi172509.
KEGGicel:CELE_T25G3.4.
UCSCiT25G3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72516 , Z73906 Genomic DNA. Translation: CAA96690.1 .
PIRi T20362.
RefSeqi NP_492115.1. NM_059714.4.
UniGenei Cel.38689.

3D structure databases

ProteinModelPortali P90795.
SMRi P90795. Positions 73-590, 621-690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T25G3.4.

Proteomic databases

PaxDbi P90795.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T25G3.4 ; T25G3.4 ; WBGene00012031 .
GeneIDi 172509.
KEGGi cel:CELE_T25G3.4.
UCSCi T25G3.4. c. elegans.

Organism-specific databases

CTDi 172509.
WormBasei T25G3.4 ; CE14180 ; WBGene00012031 .

Phylogenomic databases

eggNOGi COG0578.
GeneTreei ENSGT00390000001718.
HOGENOMi HOG000004813.
InParanoidi P90795.
KOi K00111.
OMAi KHLTESY.
PhylomeDBi P90795.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .
Reactomei REACT_255835. Fatty acid, triacylglycerol, and ketone body metabolism.

Miscellaneous databases

NextBioi 875825.
PROi P90795.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGPDM_CAEEL
AccessioniPrimary (citable) accession number: P90795
Secondary accession number(s): Q22793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3