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Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

T25G3.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Enzyme regulationi

Calcium-binding enhances the activity of the enzyme.By similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable glycerol-3-phosphate dehydrogenase, mitochondrial (T25G3.4)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 104FADSequence analysisAdd BLAST29
Calcium bindingi673 – 684PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandCalcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-1483166 Synthesis of PA
R-CEL-163560 Triglyceride catabolism
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:T25G3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT25G3.4 ; CE14180 ; WBGene00012031

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43MitochondrionAdd BLAST43
ChainiPRO_000001043244 – 722Probable glycerol-3-phosphate dehydrogenase, mitochondrialAdd BLAST679

Proteomic databases

EPDiP90795
PaxDbiP90795
PeptideAtlasiP90795
PRIDEiP90795

Expressioni

Gene expression databases

BgeeiWBGene00012031

Interactioni

Protein-protein interaction databases

STRINGi6239.T25G3.4.2

Structurei

3D structure databases

ProteinModelPortaliP90795
SMRiP90795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini624 – 659EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini660 – 695EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG0042 Eukaryota
COG0578 LUCA
GeneTreeiENSGT00390000001718
HOGENOMiHOG000004813
InParanoidiP90795
KOiK00111
OMAiVPYYWVG
OrthoDBiEOG091G03ER
PhylomeDBiP90795

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.10.8.870, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR031656 DAO_C
IPR038299 DAO_C_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR000447 G3P_DH_FAD-dep
PANTHERiPTHR11985 PTHR11985, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16901 DAO_C, 1 hit
PF13499 EF-hand_7, 1 hit
PRINTSiPR01001 FADG3PDH
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00977 FAD_G3PDH_1, 1 hit
PS00978 FAD_G3PDH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P90795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE
60 70 80 90 100
LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT
110 120 130 140 150
ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH
160 170 180 190 200
NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI
210 220 230 240 250
NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN
260 270 280 290 300
HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM
310 320 330 340 350
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM
360 370 380 390 400
TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS
410 420 430 440 450
GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD
460 470 480 490 500
RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS
510 520 530 540 550
NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA
560 570 580 590 600
IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF
610 620 630 640 650
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR
660 670 680 690 700
KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN
710 720
RLVGYLDEIH GTPSVNRACG GI
Length:722
Mass (Da):80,807
Last modified:November 1, 1998 - v2
Checksum:i9E8BF74246480E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72516, Z73906 Genomic DNA Translation: CAA96690.1
PIRiT20362
RefSeqiNP_492115.1, NM_059714.4
UniGeneiCel.38689

Genome annotation databases

EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031
GeneIDi172509
KEGGicel:CELE_T25G3.4
UCSCiT25G3.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGPDM_CAEEL
AccessioniPrimary (citable) accession number: P90795
Secondary accession number(s): Q22793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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