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P90795

- GPDM_CAEEL

UniProt

P90795 - GPDM_CAEEL

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Protein
Probable glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
T25G3.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD By similarity.

Enzyme regulationi

Calcium-binding enhances the activity of the enzyme By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 10429FAD Reviewed prediction
Add
BLAST
Calcium bindingi673 – 68412 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:T25G3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT25G3.4; CE14180; WBGene00012031.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion
Add
BLAST
Chaini44 – 722679Probable glycerol-3-phosphate dehydrogenase, mitochondrial
PRO_0000010432Add
BLAST

Proteomic databases

PaxDbiP90795.

Interactioni

Protein-protein interaction databases

STRINGi6239.T25G3.4.

Structurei

3D structure databases

ProteinModelPortaliP90795.
SMRiP90795. Positions 73-590, 621-690.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini624 – 65936EF-hand 1
Add
BLAST
Domaini660 – 69536EF-hand 2
Add
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
InParanoidiP90795.
KOiK00111.
OMAiKHLTESY.
PhylomeDBiP90795.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P90795-1 [UniParc]FASTAAdd to Basket

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MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE    50
LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT 100
ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH 150
NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI 200
NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN 250
HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM 300
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM 350
TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS 400
GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD 450
RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS 500
NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA 550
IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF 600
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR 650
KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN 700
RLVGYLDEIH GTPSVNRACG GI 722
Length:722
Mass (Da):80,807
Last modified:November 1, 1998 - v2
Checksum:i9E8BF74246480E30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
PIRiT20362.
RefSeqiNP_492115.1. NM_059714.4.
UniGeneiCel.38689.

Genome annotation databases

EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031.
GeneIDi172509.
KEGGicel:CELE_T25G3.4.
UCSCiT25G3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72516 , Z73906 Genomic DNA. Translation: CAA96690.1 .
PIRi T20362.
RefSeqi NP_492115.1. NM_059714.4.
UniGenei Cel.38689.

3D structure databases

ProteinModelPortali P90795.
SMRi P90795. Positions 73-590, 621-690.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6239.T25G3.4.

Proteomic databases

PaxDbi P90795.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T25G3.4 ; T25G3.4 ; WBGene00012031 .
GeneIDi 172509.
KEGGi cel:CELE_T25G3.4.
UCSCi T25G3.4. c. elegans.

Organism-specific databases

CTDi 172509.
WormBasei T25G3.4 ; CE14180 ; WBGene00012031 .

Phylogenomic databases

eggNOGi COG0578.
GeneTreei ENSGT00390000001718.
HOGENOMi HOG000004813.
InParanoidi P90795.
KOi K00111.
OMAi KHLTESY.
PhylomeDBi P90795.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .

Miscellaneous databases

NextBioi 875825.
PROi P90795.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGPDM_CAEEL
AccessioniPrimary (citable) accession number: P90795
Secondary accession number(s): Q22793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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