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P90795

- GPDM_CAEEL

UniProt

P90795 - GPDM_CAEEL

Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

T25G3.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity

    Enzyme regulationi

    Calcium-binding enhances the activity of the enzyme.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi76 – 10429FADSequence AnalysisAdd
    BLAST
    Calcium bindingi673 – 68412PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calcium, FAD, Flavoprotein, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
    Short name:
    GPD-M
    Short name:
    GPDH-M
    Gene namesi
    ORF Names:T25G3.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiT25G3.4; CE14180; WBGene00012031.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionAdd
    BLAST
    Chaini44 – 722679Probable glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000010432Add
    BLAST

    Proteomic databases

    PaxDbiP90795.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T25G3.4.

    Structurei

    3D structure databases

    ProteinModelPortaliP90795.
    SMRiP90795. Positions 73-590, 621-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini624 – 65936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini660 – 69536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiCOG0578.
    GeneTreeiENSGT00390000001718.
    HOGENOMiHOG000004813.
    InParanoidiP90795.
    KOiK00111.
    OMAiKHLTESY.
    PhylomeDBiP90795.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P90795-1 [UniParc]FASTAAdd to Basket

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    MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE    50
    LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT 100
    ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH 150
    NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI 200
    NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN 250
    HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM 300
    GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM 350
    TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS 400
    GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD 450
    RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS 500
    NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA 550
    IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF 600
    IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR 650
    KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN 700
    RLVGYLDEIH GTPSVNRACG GI 722
    Length:722
    Mass (Da):80,807
    Last modified:November 1, 1998 - v2
    Checksum:i9E8BF74246480E30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
    PIRiT20362.
    RefSeqiNP_492115.1. NM_059714.4.
    UniGeneiCel.38689.

    Genome annotation databases

    EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031.
    GeneIDi172509.
    KEGGicel:CELE_T25G3.4.
    UCSCiT25G3.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72516 , Z73906 Genomic DNA. Translation: CAA96690.1 .
    PIRi T20362.
    RefSeqi NP_492115.1. NM_059714.4.
    UniGenei Cel.38689.

    3D structure databases

    ProteinModelPortali P90795.
    SMRi P90795. Positions 73-590, 621-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T25G3.4.

    Proteomic databases

    PaxDbi P90795.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T25G3.4 ; T25G3.4 ; WBGene00012031 .
    GeneIDi 172509.
    KEGGi cel:CELE_T25G3.4.
    UCSCi T25G3.4. c. elegans.

    Organism-specific databases

    CTDi 172509.
    WormBasei T25G3.4 ; CE14180 ; WBGene00012031 .

    Phylogenomic databases

    eggNOGi COG0578.
    GeneTreei ENSGT00390000001718.
    HOGENOMi HOG000004813.
    InParanoidi P90795.
    KOi K00111.
    OMAi KHLTESY.
    PhylomeDBi P90795.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .

    Miscellaneous databases

    NextBioi 875825.
    PROi P90795.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGPDM_CAEEL
    AccessioniPrimary (citable) accession number: P90795
    Secondary accession number(s): Q22793
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3