Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

T25G3.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Enzyme regulationi

Calcium-binding enhances the activity of the enzyme.By similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable glycerol-3-phosphate dehydrogenase, mitochondrial (T25G3.4)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 104FADSequence analysisAdd BLAST29
Calcium bindingi673 – 684PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-535734. Fatty acid, triacylglycerol, and ketone body metabolism.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
ORF Names:T25G3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT25G3.4; CE14180; WBGene00012031.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43MitochondrionAdd BLAST43
ChainiPRO_000001043244 – 722Probable glycerol-3-phosphate dehydrogenase, mitochondrialAdd BLAST679

Proteomic databases

EPDiP90795.
PaxDbiP90795.
PeptideAtlasiP90795.
PRIDEiP90795.

Expressioni

Gene expression databases

BgeeiWBGene00012031.

Interactioni

Protein-protein interaction databases

STRINGi6239.T25G3.4.2.

Structurei

3D structure databases

ProteinModelPortaliP90795.
SMRiP90795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini624 – 659EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini660 – 695EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG0042. Eukaryota.
COG0578. LUCA.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
InParanoidiP90795.
KOiK00111.
OMAiCIVNAAG.
OrthoDBiEOG091G03ER.
PhylomeDBiP90795.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR031656. DAO_C.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16901. DAO_C. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P90795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE
60 70 80 90 100
LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT
110 120 130 140 150
ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH
160 170 180 190 200
NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI
210 220 230 240 250
NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN
260 270 280 290 300
HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM
310 320 330 340 350
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM
360 370 380 390 400
TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS
410 420 430 440 450
GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD
460 470 480 490 500
RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS
510 520 530 540 550
NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA
560 570 580 590 600
IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF
610 620 630 640 650
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR
660 670 680 690 700
KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN
710 720
RLVGYLDEIH GTPSVNRACG GI
Length:722
Mass (Da):80,807
Last modified:November 1, 1998 - v2
Checksum:i9E8BF74246480E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
PIRiT20362.
RefSeqiNP_492115.1. NM_059714.4.
UniGeneiCel.38689.

Genome annotation databases

EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031.
GeneIDi172509.
KEGGicel:CELE_T25G3.4.
UCSCiT25G3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72516, Z73906 Genomic DNA. Translation: CAA96690.1.
PIRiT20362.
RefSeqiNP_492115.1. NM_059714.4.
UniGeneiCel.38689.

3D structure databases

ProteinModelPortaliP90795.
SMRiP90795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T25G3.4.2.

Proteomic databases

EPDiP90795.
PaxDbiP90795.
PeptideAtlasiP90795.
PRIDEiP90795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT25G3.4; T25G3.4; WBGene00012031.
GeneIDi172509.
KEGGicel:CELE_T25G3.4.
UCSCiT25G3.4. c. elegans.

Organism-specific databases

CTDi172509.
WormBaseiT25G3.4; CE14180; WBGene00012031.

Phylogenomic databases

eggNOGiKOG0042. Eukaryota.
COG0578. LUCA.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
InParanoidiP90795.
KOiK00111.
OMAiCIVNAAG.
OrthoDBiEOG091G03ER.
PhylomeDBiP90795.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.
ReactomeiR-CEL-535734. Fatty acid, triacylglycerol, and ketone body metabolism.

Miscellaneous databases

PROiP90795.

Gene expression databases

BgeeiWBGene00012031.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
3.50.50.60. 1 hit.
InterProiIPR031656. DAO_C.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16901. DAO_C. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF51905. SSF51905. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPDM_CAEEL
AccessioniPrimary (citable) accession number: P90795
Secondary accession number(s): Q22793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.