Reviewed, UniProtKB/Swiss-Prot P90771 (C36A1_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable cytochrome P450 CYP36A1
    EC=1.14.-.-

Gene names

Name:	cyp-36A1
Synonyms:	cyp36a1
ORF Names:	C34B7.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	O18302	1	EBI-316576,EBI-312747

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Probable cytochrome P450 CYP36A1		PRO_0000052270
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	60 – 80	21	Potential
	Transmembrane	290 – 310	21	Potential
Sites
	Metal binding	440	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P90771-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 2A959C010284C33A	FASTA	493	56,982
	10 20 30 40 50 60 MLFAQLVILV IIVMLFLCRF ANKLRGLPPG PTPWPFIGNT FQVPEDRIDL IINEFKKKYG 70 80 90 100 110 120 GIFTLWLPFP TIVICDYDML KRNIVKNGES FSGRPDTFIM DMLVQGNYGL FFMENNWWKA 130 140 150 160 170 180 QRRFTTHIFR SLGVGQAGTQ DTIASLASGL VEKIDGQKDK PIELRPLLVH VVGNVIHKHL 190 200 210 220 230 240 FGFTREWNET EILDFHVAIN DVLEHFTSPK TQLLDAWPWL AYLDKPLSLG IPRTTRANDA 250 260 270 280 290 300 IIQNLEQALA KHKTGINYDE EPSSYMDAFL KEMKIRAAEN ALEDGFTEKQ LIVAIYDLYS 310 320 330 340 350 360 AGMETIIIVL RFAFLYLVNN PETQKRIHEE LDRNVGRERQ VVMDDQKHLP YTCAFLQEVY 370 380 390 400 410 420 RLGYVLPVNF LRCTLTDVED CEGYRLNAGT RVIAQFQSVH VDKKHFPDPE HFNPDRFLNS 430 440 450 460 470 480 RGEYIRDDRV NPFSMGKRSC LGENLARMEV FLYFCTLMQN FEWHTDGPYA PPIDVITSSL 490 RAPKPFTVRA SRR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z83220 Genomic DNA. Translation: CAB05702.1.
PIR	T19695.
RefSeq	NP_492267.1.
UniGene	Cel.19160
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25137N.
IntAct	P90771. 1 interaction.
Genome annotation databases
Ensembl	C34B7.3. Caenorhabditis elegans. [Contig view]
GeneID	183193.
KEGG	cel:C34B7.3.
NMPDR	fig|6239.3.peg.2174.
Organism-specific databases
WormBase	WBGene00007913. cyp-36A1.
WormPep	C34B7.3. CE08567. [WorfDB]
Phylogenomic databases
OMA	P90771. TTRANDA.
Gene expression databases
ArrayExpress	P90771.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	920246.

Entry information

Entry name

C36A1_CAEEL

Accession

Primary (citable) accession number: P90771
Secondary accession number(s): O02645

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project