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Protein

Probable manganese-transporting ATPase catp-8

Gene

catp-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei483 – 48314-aspartylphosphate intermediateBy similarity
Metal bindingi822 – 8221MagnesiumBy similarity
Metal bindingi826 – 8261MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-transporting ATPase catp-8Curated (EC:3.6.3.-)
Alternative name(s):
Cation transporting ATPase 8Imported
Gene namesi
Name:catp-8Imported
ORF Names:C10C6.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC10C6.6; CE30858; WBGene00007514; catp-8.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 436ExtracellularSequence analysis
Transmembranei44 – 6926HelicalSequence analysisAdd
BLAST
Topological domaini70 – 185116CytoplasmicSequence analysisAdd
BLAST
Transmembranei186 – 20722HelicalSequence analysisAdd
BLAST
Topological domaini208 – 2114ExtracellularSequence analysis
Transmembranei212 – 23019HelicalSequence analysisAdd
BLAST
Topological domaini231 – 394164CytoplasmicSequence analysisAdd
BLAST
Transmembranei395 – 41420HelicalSequence analysisAdd
BLAST
Topological domaini415 – 42814ExtracellularSequence analysisAdd
BLAST
Transmembranei429 – 45022HelicalSequence analysisAdd
BLAST
Topological domaini451 – 970520CytoplasmicSequence analysisAdd
BLAST
Transmembranei971 – 99020HelicalSequence analysisAdd
BLAST
Topological domaini991 – 9977ExtracellularSequence analysis
Transmembranei998 – 101417HelicalSequence analysisAdd
BLAST
Topological domaini1015 – 103218CytoplasmicSequence analysisAdd
BLAST
Transmembranei1033 – 105624HelicalSequence analysisAdd
BLAST
Topological domaini1057 – 107620ExtracellularSequence analysisAdd
BLAST
Transmembranei1077 – 109923HelicalSequence analysisAdd
BLAST
Topological domaini1100 – 111011CytoplasmicSequence analysisAdd
BLAST
Transmembranei1111 – 113020HelicalSequence analysisAdd
BLAST
Topological domaini1131 – 114717ExtracellularSequence analysisAdd
BLAST
Transmembranei1148 – 117023HelicalSequence analysisAdd
BLAST
Topological domaini1171 – 11788CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11781178Probable manganese-transporting ATPase catp-8CuratedPRO_0000046357Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP90747.
PaxDbiP90747.

Interactioni

Protein-protein interaction databases

STRINGi6239.C10C6.6.1.

Structurei

3D structure databases

ProteinModelPortaliP90747.
SMRiP90747. Positions 256-873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0209. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00550000075064.
HOGENOMiHOG000199432.
InParanoidiP90747.
KOiK14950.
OMAiYLYSEAQ.
PhylomeDBiP90747.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVDQLVETI IPYNLRSIAT HLYVPPFTII TAIWTYVWLN IFGYEEYYEL
60 70 80 90 100
GMLGYAAIFV ILALVLLFCH WMMPVRCFLM CSKQEDVRIA SHVCVIPTQN
110 120 130 140 150
NGWPELVKLM RTTRDKQTKL WFEFQRVHYT WDEESREFQT KTLDTAKPMV
160 170 180 190 200
FFQKSHGFEV EEHVKDAKYL LGDNKTEMIV PQFLEMFIER ATAPFFVFQV
210 220 230 240 250
FCVGLWCLED MWYYSLFTLF MLMTFEATLV KQQMKNMSEI RNMGNKTYMI
260 270 280 290 300
NVLRGKKWQK IKIEELVAGD IVSIGRGAEE ECVPCDLLLL RGPCIVDESM
310 320 330 340 350
LTGESVPQMK EPIEDVEKDK IFDIETDSRL HVIFGGTKIV QHTAPGKAAE
360 370 380 390 400
GMVKSPDGNC ICYVIRTGFN TSQGKLLRTI MFGVKKATAN NLETFCFILF
410 420 430 440 450
LLIFAIAAAA YLWIKGSVDE TRSKYKLFLE CTLILTSVIP PELPIELSLA
460 470 480 490 500
VNSSLMALQK LGIFCTEPFR IPFAGKVDIC CFDKTGTLTT DNLVVEGVAL
510 520 530 540 550
NNQKEGMIRN AEDLPHESLQ VLASCHSLVR FEEDLVGDPL EKACLSWCGW
560 570 580 590 600
NLTKGDAVMP PKTAAKGISG IKIFHRYHFS SAMKRMTVVA GYQSPGTSDT
610 620 630 640 650
TFIVAVKGAP EVLRNMYADL PSDYDETYTR LTRQGSRVLA MGIRKLGETR
660 670 680 690 700
VGELRDKKRE NFENDLAFAG FVVISCPLKS DTKTMIREIM DSSHVVAMIT
710 720 730 740 750
GDNPLTACHV SKVLKFTKKS LPTLVLDEPA DGVDWMWKSV DGTIELPLKP
760 770 780 790 800
ETKNKMERKA FFNSHEFCLT GSAFHHLVHN EHTFLRELIL HVKVFARMAP
810 820 830 840 850
KQKERIINEL KSLGKVTLMC GDGTNDVGAL KHANVGVALL TNPYDAEKAA
860 870 880 890 900
EKEKEKKAKI EEARSLVRSG AQLPQRPGAP GAPPAANAAR RDAPPGARAR
910 920 930 940 950
APLPPMANAA QARLDNLMKE LEEEEKAQVI KLGDASIAAP FTSKYTSIAS
960 970 980 990 1000
ICHVIKQGRC TLVTTLQMFK ILALNALVSA YSLSALYLDG VKFSDTQATI
1010 1020 1030 1040 1050
QGLLLAACFL FISKSKPLKT LSRQRPMANI FNAYTLLTVT LQFIVHFSCL
1060 1070 1080 1090 1100
LYIVGLAHEA NTEKAPVDLE AKFTPNILNT TVYIISMALQ VCTFAVNYRG
1110 1120 1130 1140 1150
RPFMESLFEN KAMLYSIMFS GGAVFTLASG QATDLMIQFE LVVLPEALRN
1160 1170
ALLMCVTADL VICYIIDRGL NFLLGDMF
Length:1,178
Mass (Da):131,973
Last modified:January 17, 2003 - v3
Checksum:i8394E3E368BE0488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83217 Genomic DNA. Translation: CAB05683.2.
PIRiT19187.
RefSeqiNP_502165.2. NM_069764.5.
UniGeneiCel.17131.

Genome annotation databases

EnsemblMetazoaiC10C6.6; C10C6.6; WBGene00007514.
GeneIDi178070.
KEGGicel:CELE_C10C6.6.
UCSCiC10C6.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83217 Genomic DNA. Translation: CAB05683.2.
PIRiT19187.
RefSeqiNP_502165.2. NM_069764.5.
UniGeneiCel.17131.

3D structure databases

ProteinModelPortaliP90747.
SMRiP90747. Positions 256-873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C10C6.6.1.

Proteomic databases

EPDiP90747.
PaxDbiP90747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C6.6; C10C6.6; WBGene00007514.
GeneIDi178070.
KEGGicel:CELE_C10C6.6.
UCSCiC10C6.6. c. elegans.

Organism-specific databases

CTDi178070.
WormBaseiC10C6.6; CE30858; WBGene00007514; catp-8.

Phylogenomic databases

eggNOGiKOG0209. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00550000075064.
HOGENOMiHOG000199432.
InParanoidiP90747.
KOiK14950.
OMAiYLYSEAQ.
PhylomeDBiP90747.

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiP90747.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiAT131_CAEEL
AccessioniPrimary (citable) accession number: P90747
Secondary accession number(s): O02620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 17, 2003
Last modified: June 8, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.