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P90747 (YE56_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cation-transporting ATPase C10C6.6
EC=3.6.3.-
Gene names
ORF Names:C10C6.6
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11781178Probable cation-transporting ATPase C10C6.6
PRO_0000046357

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 436Extracellular Potential
Transmembrane44 – 6926Helical; Potential
Topological domain70 – 185116Cytoplasmic Potential
Transmembrane186 – 20722Helical; Potential
Topological domain208 – 2114Extracellular Potential
Transmembrane212 – 23019Helical; Potential
Topological domain231 – 394164Cytoplasmic Potential
Transmembrane395 – 41420Helical; Potential
Topological domain415 – 42814Extracellular Potential
Transmembrane429 – 45022Helical; Potential
Topological domain451 – 970520Cytoplasmic Potential
Transmembrane971 – 99020Helical; Potential
Topological domain991 – 9977Extracellular Potential
Transmembrane998 – 101417Helical; Potential
Topological domain1015 – 103218Cytoplasmic Potential
Transmembrane1033 – 105624Helical; Potential
Topological domain1057 – 107620Extracellular Potential
Transmembrane1077 – 109923Helical; Potential
Topological domain1100 – 111011Cytoplasmic Potential
Transmembrane1111 – 113020Helical; Potential
Topological domain1131 – 114717Extracellular Potential
Transmembrane1148 – 117023Helical; Potential
Topological domain1171 – 11788Cytoplasmic Potential

Sites

Active site48314-aspartylphosphate intermediate By similarity
Metal binding8221Magnesium By similarity
Metal binding8261Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P90747 [UniParc].

Last modified January 17, 2003. Version 3.
Checksum: 8394E3E368BE0488

FASTA1,178131,973
        10         20         30         40         50         60 
MGVDQLVETI IPYNLRSIAT HLYVPPFTII TAIWTYVWLN IFGYEEYYEL GMLGYAAIFV 

        70         80         90        100        110        120 
ILALVLLFCH WMMPVRCFLM CSKQEDVRIA SHVCVIPTQN NGWPELVKLM RTTRDKQTKL 

       130        140        150        160        170        180 
WFEFQRVHYT WDEESREFQT KTLDTAKPMV FFQKSHGFEV EEHVKDAKYL LGDNKTEMIV 

       190        200        210        220        230        240 
PQFLEMFIER ATAPFFVFQV FCVGLWCLED MWYYSLFTLF MLMTFEATLV KQQMKNMSEI 

       250        260        270        280        290        300 
RNMGNKTYMI NVLRGKKWQK IKIEELVAGD IVSIGRGAEE ECVPCDLLLL RGPCIVDESM 

       310        320        330        340        350        360 
LTGESVPQMK EPIEDVEKDK IFDIETDSRL HVIFGGTKIV QHTAPGKAAE GMVKSPDGNC 

       370        380        390        400        410        420 
ICYVIRTGFN TSQGKLLRTI MFGVKKATAN NLETFCFILF LLIFAIAAAA YLWIKGSVDE 

       430        440        450        460        470        480 
TRSKYKLFLE CTLILTSVIP PELPIELSLA VNSSLMALQK LGIFCTEPFR IPFAGKVDIC 

       490        500        510        520        530        540 
CFDKTGTLTT DNLVVEGVAL NNQKEGMIRN AEDLPHESLQ VLASCHSLVR FEEDLVGDPL 

       550        560        570        580        590        600 
EKACLSWCGW NLTKGDAVMP PKTAAKGISG IKIFHRYHFS SAMKRMTVVA GYQSPGTSDT 

       610        620        630        640        650        660 
TFIVAVKGAP EVLRNMYADL PSDYDETYTR LTRQGSRVLA MGIRKLGETR VGELRDKKRE 

       670        680        690        700        710        720 
NFENDLAFAG FVVISCPLKS DTKTMIREIM DSSHVVAMIT GDNPLTACHV SKVLKFTKKS 

       730        740        750        760        770        780 
LPTLVLDEPA DGVDWMWKSV DGTIELPLKP ETKNKMERKA FFNSHEFCLT GSAFHHLVHN 

       790        800        810        820        830        840 
EHTFLRELIL HVKVFARMAP KQKERIINEL KSLGKVTLMC GDGTNDVGAL KHANVGVALL 

       850        860        870        880        890        900 
TNPYDAEKAA EKEKEKKAKI EEARSLVRSG AQLPQRPGAP GAPPAANAAR RDAPPGARAR 

       910        920        930        940        950        960 
APLPPMANAA QARLDNLMKE LEEEEKAQVI KLGDASIAAP FTSKYTSIAS ICHVIKQGRC 

       970        980        990       1000       1010       1020 
TLVTTLQMFK ILALNALVSA YSLSALYLDG VKFSDTQATI QGLLLAACFL FISKSKPLKT 

      1030       1040       1050       1060       1070       1080 
LSRQRPMANI FNAYTLLTVT LQFIVHFSCL LYIVGLAHEA NTEKAPVDLE AKFTPNILNT 

      1090       1100       1110       1120       1130       1140 
TVYIISMALQ VCTFAVNYRG RPFMESLFEN KAMLYSIMFS GGAVFTLASG QATDLMIQFE 

      1150       1160       1170 
LVVLPEALRN ALLMCVTADL VICYIIDRGL NFLLGDMF

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z83217 Genomic DNA. Translation: CAB05683.2.
PIRT19187.
RefSeqNP_502165.2. NM_069764.4.
UniGeneCel.17131.

3D structure databases

ProteinModelPortalP90747.
SMRP90747. Positions 236-383, 794-854.
ModBaseSearch...

Protein-protein interaction databases

STRINGP90747.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC10C6.6.1; C10C6.6.1; C10C6.6.
C10C6.6.2; C10C6.6.2; C10C6.6.
GeneID178070.
KEGGcel:C10C6.6.
NMPDRfig|6239.3.peg.15218.
UCSCC10C6.6. c. elegans.

Organism-specific databases

CTD178070.
WormBaseC10C6.6; CE30858; WBGene00007514.

Phylogenomic databases

eggNOGmeNOG04141.
GeneTreeEMGT00070000025723.
HOGENOMHBG316596.
InParanoidP90747.
OMAVISCPLK.
PhylomeDBP90747.

Gene expression databases

ArrayExpressP90747.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006544. ATPase_P-typ_unknown-pump-sp.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK14950.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio899588.

Entry information

Entry nameYE56_CAEEL
AccessionPrimary (citable) accession number: P90747
Secondary accession number(s): O02620
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 17, 2003
Last modified: December 14, 2011
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents