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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene

eat-6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: WormBase
  • metal ion binding Source: UniProtKB-KW
  • sodium:potassium-exchanging ATPase activity Source: WormBase

GO - Biological processi

  • action potential Source: WormBase
  • ATP hydrolysis coupled transmembrane transport Source: GOC
  • establishment or maintenance of transmembrane electrochemical gradient Source: WormBase
  • potassium ion transport Source: WormBase
  • regulation of membrane potential Source: WormBase
  • regulation of muscle contraction Source: WormBase
  • reproduction Source: WormBase
  • sodium ion transport Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotation, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, Potassium

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alphaUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:eat-6Imported
ORF Names:B0365.3Imported, CELE_B0365.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0365.3; CE07721; WBGene00001137; eat-6.

Subcellular locationi

  • Membrane UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei74 – 9320HelicalUniRule annotationAdd
BLAST
Transmembranei108 – 12720HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 29325HelicalUniRule annotationAdd
BLAST
Transmembranei299 – 32224HelicalUniRule annotationAdd
BLAST
Transmembranei822 – 84524HelicalUniRule annotationAdd
BLAST
Transmembranei886 – 90520HelicalUniRule annotationAdd
BLAST
Transmembranei925 – 94622HelicalUniRule annotationAdd
BLAST
Transmembranei958 – 97417HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: WormBase
  • plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiP90735.
PaxDbiP90735.

Expressioni

Gene expression databases

ExpressionAtlasiP90735. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-24764N.
MINTiMINT-1058306.
STRINGi6239.B0365.3.1.

Structurei

3D structure databases

ProteinModelPortaliP90735.
SMRiP90735. Positions 8-996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 9475Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]SAAS annotation
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129739.
HOGENOMiHOG000265622.
InParanoidiP90735.
KOiK01539.
OMAiLGFCDFM.
PhylomeDBiP90735.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKDKKQEL HDLKQEVKMD EHIVPIEELV ARLGTNLETG LTRQKAQEVL
60 70 80 90 100
AKNGPNALSP PETTPEWIKF CKNLFGGFAM LLWVGAILCY IAYSVDYFTM
110 120 130 140 150
EYPSKDNLYL GIVLMTVVVI TGVFQYYQES KSSKIMDSFK NMVPTFALVH
160 170 180 190 200
RDGQKQQVKT EELVVGDIVE VKGGDRVPAD LRVVSAFGFK VDNSSLTGES
210 220 230 240 250
EPQSRSPDCT NENPLETRNI AFFSTNAVEG TAKGIVIYTG DNTVMGRIAH
260 270 280 290 300
LASGLDTGMT PIAREIEHFI HLITGVAVFL GISFFIIAFI LGYHWLTAVV
310 320 330 340 350
FLIGIIVANV PEGLIATVTV CLTLTAKRMA SKNCLVKNLE AVETLGSTST
360 370 380 390 400
ICSDKTGTLT QNRMTVAHMW YDETIHECDT TETQTSQEKR TGASFEALVR
410 420 430 440 450
IASLCNRAEF KAGQQDTPIL RRDCTGDASE IALLKFTELT QGNVIAVREK
460 470 480 490 500
NKKIAEIPFN STNKYQVSIH DNGDHYLLVM KGAPERILDV CSTIFLNGKE
510 520 530 540 550
SELTDKLRED FNTAYLELGG MGERVLGFCD FVLPADKFPK GFKFDVEEVN
560 570 580 590 600
FPLKNLRFVG LMSMIDPPRA AVPDAVAKCR SAGIKVVMVT GDHPITAKAI
610 620 630 640 650
AKSVGIISDG TETVEDIAIR RGIPVEEVNP REAKAAVIHG SDLREMSEDQ
660 670 680 690 700
LAEIIKYHSE IVFARTSPQQ KLMIVEGFQK QGQIVAVTGD GVNDSPALKK
710 720 730 740 750
ADIGVAMGIA GSDVSKQAAD MILLDDNFAS IVVGVEEGRL IFDNLKKSIA
760 770 780 790 800
YTLTSNIPEI SPFLTYILFG IPLPLGTVTI LCIDLGTDMV PAISLAYEEA
810 820 830 840 850
ESDIMKRQPR DPIRDKLVNE RLISLAYGQI GMIQASAGFF TYFWIMADNG
860 870 880 890 900
FMPWDLYQLR AQWDSRAYNN VLDSYGQEWT YANRKILEYT CQTAYFVSIV
910 920 930 940 950
VVQWADLIIS KTRRNSLVQQ GMSNWTLNFG LVFETALAWF MCYCPGLDNG
960 970 980 990
LRMYGLRFSW WFCALPFSIL IFVYDEIRRF LIRRYPGGWV ERETYY
Length:996
Mass (Da):111,003
Last modified:May 1, 1997 - v1
Checksum:iB38E398C50673664
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02694.1.
PIRiT18717.
RefSeqiNP_506269.1. NM_073868.3.
UniGeneiCel.17890.

Genome annotation databases

EnsemblMetazoaiB0365.3.1; B0365.3.1; WBGene00001137.
B0365.3.2; B0365.3.2; WBGene00001137.
GeneIDi179796.
KEGGicel:CELE_B0365.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02694.1.
PIRiT18717.
RefSeqiNP_506269.1. NM_073868.3.
UniGeneiCel.17890.

3D structure databases

ProteinModelPortaliP90735.
SMRiP90735. Positions 8-996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24764N.
MINTiMINT-1058306.
STRINGi6239.B0365.3.1.

Proteomic databases

EPDiP90735.
PaxDbiP90735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0365.3.1; B0365.3.1; WBGene00001137.
B0365.3.2; B0365.3.2; WBGene00001137.
GeneIDi179796.
KEGGicel:CELE_B0365.3.

Organism-specific databases

CTDi179796.
WormBaseiB0365.3; CE07721; WBGene00001137; eat-6.

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00840000129739.
HOGENOMiHOG000265622.
InParanoidiP90735.
KOiK01539.
OMAiLGFCDFM.
PhylomeDBiP90735.

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Gene expression databases

ExpressionAtlasiP90735. baseline.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP90735_CAEEL
AccessioniPrimary (citable) accession number: P90735
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.