Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-18

Gene

rab-18

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:rab-18
ORF Names:CBG15153
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG15153; CBP18335; WBGene00035481; Cbr-rab-18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Ras-related protein Rab-18PRO_0000121199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity
Modified residuei202 – 2021Cysteine methyl esterBy similarity
Lipidationi202 – 2021S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP90726.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG15153.

Structurei

3D structure databases

ProteinModelPortaliP90726.
SMRiP90726. Positions 9-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000233968.
InParanoidiP90726.
KOiK07910.
OMAiSYYRDAQ.
OrthoDBiEOG7CVQ04.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDSSSPLT TLKILIIGES GVGKSSLMLR FVDDVFDPEQ AATIGVDFRV
60 70 80 90 100
TSMTIDGNRV KLAIWDTAGQ ERFRTLTPSY YRGAQGVICV YDVTSRSSFE
110 120 130 140 150
KLKHWMTEVD TYCTNDNVIK MMVANKIDMP NRTVTREEGL KFAKRHRTLF
160 170 180 190 200
IEASAKTKEG VQCTFEELIE KIIQTPDLWD NDRPTFRLGQ PTDTSSGNLC

GC
Length:202
Mass (Da):22,723
Last modified:May 1, 1997 - v1
Checksum:iE1989ED6D6093A78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79145 Genomic DNA. Translation: AAB38279.1.
HE601055 Genomic DNA. Translation: CAP33591.1.
RefSeqiXP_002642883.1. XM_002642837.1.

Genome annotation databases

EnsemblMetazoaiCBG15153; CBG15153; WBGene00035481.
GeneIDi8584876.
KEGGicbr:CBG15153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79145 Genomic DNA. Translation: AAB38279.1.
HE601055 Genomic DNA. Translation: CAP33591.1.
RefSeqiXP_002642883.1. XM_002642837.1.

3D structure databases

ProteinModelPortaliP90726.
SMRiP90726. Positions 9-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG15153.

Proteomic databases

PRIDEiP90726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG15153; CBG15153; WBGene00035481.
GeneIDi8584876.
KEGGicbr:CBG15153.

Organism-specific databases

CTDi8584876.
WormBaseiCBG15153; CBP18335; WBGene00035481; Cbr-rab-18.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000233968.
InParanoidiP90726.
KOiK07910.
OMAiSYYRDAQ.
OrthoDBiEOG7CVQ04.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon."
    Zorio D.A.R., Lea K., Blumenthal T.
    Mol. Cell. Biol. 17:946-953(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiRAB18_CAEBR
AccessioniPrimary (citable) accession number: P90726
Secondary accession number(s): A8XLT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.