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Protein

Catalase

Gene

CAT

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74PROSITE-ProRule annotation1
Active sitei147PROSITE-ProRule annotation1
Metal bindingi357Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:CAT
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849081 – 541CatalaseAdd BLAST541

Structurei

3D structure databases

ProteinModelPortaliP90682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQTKGKPHE EQLEQYKNSQ TKPFVLTTSN GAPIFNKKAS LTVGPRGPLL
60 70 80 90 100
LQDVVFLDEM AHFDRERIPE RVVHAKGGGA HGFFEVTDDI TKYCKADVFS
110 120 130 140 150
TIGKRTPIFI RFSTVGGELG SADTQRDPRG FAIKFYTEEG NWDLVGNNTP
160 170 180 190 200
IFFIRDPIFF PNFIHTQKRN PVTHLKDPNM MWDFFSLRPE TTHQVMILFG
210 220 230 240 250
DRGIPDGFRH MDGFGSHTFK LVNKDGNAVY CKFHIKTAQG IRNLPPDVAI
260 270 280 290 300
KLAGEDPDYS IRDLYDSIEN GNYPVWRLMI QVMTFEEAAN YRFNPFDITK
310 320 330 340 350
VWSHKEFPLI LVGKIVLNKN PTNYFAEVEQ IAFAPSHVVP GIEFSPDKML
360 370 380 390 400
QGRLFAYPDT QFHRLGPNYV QLPINCPYRS RAHNTQRDGC FALDYNQGGM
410 420 430 440 450
PTYHPNSFNG AIERTDVKES AWSVSGDVDR FNGDDEDNFS QPRDLWLKVM
460 470 480 490 500
DETERARLVD NIADSLKYCK AFIQERAINN FTQVHQDFGN ALRNALQKAN
510 520 530 540
EAMQKKREEE AEFNAKESVM MPCAIDDRMK NISNLAKYCK Y
Length:541
Mass (Da):61,962
Last modified:January 1, 1998 - v2
Checksum:i70890E1AECA170B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10611 mRNA. Translation: CAA71618.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10611 mRNA. Translation: CAA71618.1.

3D structure databases

ProteinModelPortaliP90682.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_ASCSU
AccessioniPrimary (citable) accession number: P90682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.