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Protein

Thioredoxin domain-containing protein 3 homolog

Gene

NME8

Organism
Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required during the final stages of sperm tail maturation. May act by reducing disulfide bonds within the sperm components (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 3 homolog
Alternative name(s):
Intermediate chain 1
NME/NM23 family member 8
Gene namesi
Name:NME8
Synonyms:IC1
OrganismiHeliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)
Taxonomic identifieri1043166 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinometridaeHeliocidaris

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201591 – 837Thioredoxin domain-containing protein 3 homologAdd BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 42Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP90666

Expressioni

Tissue specificityi

Testis-specific. In sperm, it is a component of the arm dynein of sperm axoneme.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP90666
SMRiP90666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 115ThioredoxinAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 345NDK 1Add BLAST145
Regioni355 – 491NDK 2Add BLAST137
Regioni493 – 629NDK 3Add BLAST137

Domaini

Sequence similaritiesi

In the C-terminal section; belongs to the NDK family.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.30.70.141, 3 hits
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00334 NDK, 3 hits
PF00085 Thioredoxin, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 3 hits
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54919 SSF54919, 3 hits
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

P90666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKKEQIQL QKEILNQEMW DELLSLEGLT VIDVYQKWCG PCAAVLSLFK
60 70 80 90 100
RLRNEIGDDL LRFAVAEADS IETLERYRGK CEPCFLRYGS GQLVNVVRGV
110 120 130 140 150
NAPALLKNVE RELKQEHKVL EEGVERVVIK DPLLAAFEAE EQQAAQAEEL
160 170 180 190 200
EKKRLEEEAR IKEIKELGDA GEVSVRPVSQ GTVDTLMHGR QDGPQTEPVP
210 220 230 240 250
KEVTVVLIKP DAVANGHVDS IIAKIEEHGF EILTTEDKTL TEDEAREFYK
260 270 280 290 300
QHEEEEHFEV LVTFMASGPS KILVLTRGDT GEGVVSEVRN LLGPKDIEVA
310 320 330 340 350
KEEAPDSLRA QFGTDKKMNA MHGADSKETA AREMAFLLPN FSVPIVPGTG
360 370 380 390 400
PPPTIEKTLA LIRPSALKDH KDEMLQKIQE AGFEVCLQKM VQLTEDQAKE
410 420 430 440 450
FYKEQEGTPH FEDLIREMTS GEVLALGLAK ESAIQSWREF IGPTTIDEAK
460 470 480 490 500
EKAPDSLRAQ YSIPDTQVNV VHGSDSVDTA EKELGFFFPK QTTLAVIKPD
510 520 530 540 550
AAGEHKEAII EKIKEAGFNI SLQRDVELNK ELASKLYLEH EGKEFYENLI
560 570 580 590 600
DHMSSGLSMV MVLSREDAVD GWRTLMGPTD PDYAREHAPE SLRALLGKDV
610 620 630 640 650
LQNAVHGSSN PEEAKTRIER LFPDVEVLPG GEVKDSVASI SMEQSQVKGE
660 670 680 690 700
GEEGGEEQTE QPAGEGEEQQ AEQPAAESGE QQAEGGEPAT ETATEGGEQQ
710 720 730 740 750
AEQPPAEGGE KPAEEETQQT QEGETPAADE AQAEQTQEGE TPAADEAQAE
760 770 780 790 800
QTQEGEEQKP AEEEAAPATE ETAAEQAPAA EETQQTQEGE EKKEETEQTQ
810 820 830
DAPAAGGGEE AVATEGGGEG DAKPEGGEEK TEEQTAS
Length:837
Mass (Da):91,624
Last modified:May 1, 1997 - v1
Checksum:i20F56ACDC0F19BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63884 mRNA Translation: BAA09934.1
PIRiT02761

Similar proteinsi

Entry informationi

Entry nameiTXND3_HELCR
AccessioniPrimary (citable) accession number: P90666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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