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Protein

Thioredoxin domain-containing protein 3 homolog

Gene

NME8

Organism
Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be required during the final stages of sperm tail maturation. May act by reducing disulfide bonds within the sperm components (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 3 homolog
Alternative name(s):
Intermediate chain 1
NME/NM23 family member 8
Gene namesi
Name:NME8
Synonyms:IC1
OrganismiHeliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)
Taxonomic identifieri1043166 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinometridaeHeliocidaris

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Thioredoxin domain-containing protein 3 homologPRO_0000120159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 42Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Testis-specific. In sperm, it is a component of the arm dynein of sperm axoneme.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP90666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 115110ThioredoxinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 345145NDK 1Add
BLAST
Regioni355 – 491137NDK 2Add
BLAST
Regioni493 – 629137NDK 3Add
BLAST

Domaini

Sequence similaritiesi

In the C-terminal section; belongs to the NDK family.Curated
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00334. NDK. 3 hits.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00469. NDP_KINASES. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKKEQIQL QKEILNQEMW DELLSLEGLT VIDVYQKWCG PCAAVLSLFK
60 70 80 90 100
RLRNEIGDDL LRFAVAEADS IETLERYRGK CEPCFLRYGS GQLVNVVRGV
110 120 130 140 150
NAPALLKNVE RELKQEHKVL EEGVERVVIK DPLLAAFEAE EQQAAQAEEL
160 170 180 190 200
EKKRLEEEAR IKEIKELGDA GEVSVRPVSQ GTVDTLMHGR QDGPQTEPVP
210 220 230 240 250
KEVTVVLIKP DAVANGHVDS IIAKIEEHGF EILTTEDKTL TEDEAREFYK
260 270 280 290 300
QHEEEEHFEV LVTFMASGPS KILVLTRGDT GEGVVSEVRN LLGPKDIEVA
310 320 330 340 350
KEEAPDSLRA QFGTDKKMNA MHGADSKETA AREMAFLLPN FSVPIVPGTG
360 370 380 390 400
PPPTIEKTLA LIRPSALKDH KDEMLQKIQE AGFEVCLQKM VQLTEDQAKE
410 420 430 440 450
FYKEQEGTPH FEDLIREMTS GEVLALGLAK ESAIQSWREF IGPTTIDEAK
460 470 480 490 500
EKAPDSLRAQ YSIPDTQVNV VHGSDSVDTA EKELGFFFPK QTTLAVIKPD
510 520 530 540 550
AAGEHKEAII EKIKEAGFNI SLQRDVELNK ELASKLYLEH EGKEFYENLI
560 570 580 590 600
DHMSSGLSMV MVLSREDAVD GWRTLMGPTD PDYAREHAPE SLRALLGKDV
610 620 630 640 650
LQNAVHGSSN PEEAKTRIER LFPDVEVLPG GEVKDSVASI SMEQSQVKGE
660 670 680 690 700
GEEGGEEQTE QPAGEGEEQQ AEQPAAESGE QQAEGGEPAT ETATEGGEQQ
710 720 730 740 750
AEQPPAEGGE KPAEEETQQT QEGETPAADE AQAEQTQEGE TPAADEAQAE
760 770 780 790 800
QTQEGEEQKP AEEEAAPATE ETAAEQAPAA EETQQTQEGE EKKEETEQTQ
810 820 830
DAPAAGGGEE AVATEGGGEG DAKPEGGEEK TEEQTAS
Length:837
Mass (Da):91,624
Last modified:May 1, 1997 - v1
Checksum:i20F56ACDC0F19BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63884 mRNA. Translation: BAA09934.1.
PIRiT02761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63884 mRNA. Translation: BAA09934.1.
PIRiT02761.

3D structure databases

ProteinModelPortaliP90666.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00334. NDK. 3 hits.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00469. NDP_KINASES. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Is outer arm dynein intermediate chain 1 multifunctional?"
    Ogawa K., Takai H., Ogiwara A., Yokota E., Shimizu T., Inaba K., Mohri H.
    Mol. Biol. Cell 7:1895-1907(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 390-403; 561-570 AND 576-590, TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiTXND3_HELCR
AccessioniPrimary (citable) accession number: P90666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.