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Protein

Myosin heavy chain kinase B

Gene

mhkB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament.

Catalytic activityi

ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi298 – 303ATPSequence analysis6

GO - Molecular functioni

  • ATP binding Source: dictyBase
  • myosin heavy chain kinase activity Source: dictyBase
  • myosin II binding Source: dictyBase
  • protein serine/threonine kinase activity Source: dictyBase

GO - Biological processi

  • mitotic cytokinesis Source: dictyBase
  • myosin II filament disassembly Source: dictyBase
  • peptidyl-threonine phosphorylation Source: dictyBase
  • protein autophosphorylation Source: dictyBase
  • response to differentiation-inducing factor 1 Source: dictyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.7 1939
ReactomeiR-DDI-166208 mTORC1-mediated signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin heavy chain kinase B (EC:2.7.11.7)
Short name:
MHCK-B
Gene namesi
Name:mhkB
Synonyms:mhckB
ORF Names:DDB_G0289115
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289115 mhkB

Subcellular locationi

GO - Cellular componenti

  • actomyosin contractile ring Source: dictyBase
  • cytoplasm Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510481 – 732Myosin heavy chain kinase BAdd BLAST732

Proteomic databases

PaxDbiP90648

Interactioni

GO - Molecular functioni

  • myosin II binding Source: dictyBase

Protein-protein interaction databases

STRINGi44689.DDB0191333

Structurei

3D structure databases

ProteinModelPortaliP90648
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 328Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST205
Repeati458 – 486WD 1Add BLAST29
Repeati500 – 528WD 2Add BLAST29
Repeati540 – 568WD 3Add BLAST29
Repeati580 – 608WD 4Add BLAST29
Repeati620 – 648WD 5Add BLAST29
Repeati660 – 688WD 6Add BLAST29
Repeati700 – 730WD 7Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi355 – 381Poly-AsnAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQC6 Eukaryota
ENOG410YE3S LUCA
InParanoidiP90648
OMAiVESICYN
PhylomeDBiP90648

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P90648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFKVWFSYE DEEVELSELT NDTTVSAIRK ILHEGKIFRF PYGTSQTDLQ
60 70 80 90 100
IGKMLPSGSG GGATADSKFE KFKARNTLAD IQYKVGDTLY VRVKKSKPTN
110 120 130 140 150
DSLLPTLNIA FLDGSERAIK WEYDPYTTTA QWTCTATLVK VEPVPFAEGA
160 170 180 190 200
FRKAYHTLDL SKSGASGRYV SKIGKKPTPR PSYFEDVKMQ MIAKKWADKY
210 220 230 240 250
NSFKPPKKIE FLQSCVLEFV DRTSSDLICG AEPYVEGQYR KYNNNSGFVS
260 270 280 290 300
NDERNTPQSF SHFTYEHSNH QLLIIDIQGV GDHYTDPQIH TYDGVGFGIG
310 320 330 340 350
NLGQKGFEKF LDTHKCNAIC QYLNLQSINP KSEKSDCGTV PRPDLIFPDT
360 370 380 390 400
SERDNNNNNN NNNNNNNNNN NNNSNNNNNN NSSISKSLVE ISSGSKERND
410 420 430 440 450
RDSPSRQLFV SNDGNTLNTN KERSKSKSID LEKPEILINN KKKESINLET
460 470 480 490 500
IKLIETIKGY HVTSHLCICD NLLFTGCSDN SIRVYDYKSQ NMECVQTLKG
510 520 530 540 550
HEGPVESICY NDQYLFSGSS DHSIKVWDLK KLRCIFTLEG HDKPVHTVLL
560 570 580 590 600
NDKYLFSGSS DKTIKVWDLK TLECKYTLES HARAVKTLCI SGQYLFSGSN
610 620 630 640 650
DKTIKVWDLK TFRCNYTLKG HTKWVTTICI LGTNLYSGSY DKTIRVWNLK
660 670 680 690 700
SLECSATLRG HDRWVEHMVI CDKLLFTASD DNTIKIWDLE TLRCNTTLEG
710 720 730
HNATVQCLAV WEDKKCVISC SHDQSIRVWG WN
Length:732
Mass (Da):83,168
Last modified:May 1, 1997 - v1
Checksum:iA7233C4BD56D4088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90946 mRNA Translation: AAB50136.1
AAFI02000130 Genomic DNA Translation: EAL62865.1
RefSeqiXP_636368.1, XM_631276.1

Genome annotation databases

EnsemblProtistsiEAL62865; EAL62865; DDB_G0289115
GeneIDi8626969
KEGGiddi:DDB_G0289115

Similar proteinsi

Entry informationi

Entry nameiMHCKB_DICDI
AccessioniPrimary (citable) accession number: P90648
Secondary accession number(s): Q54HZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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