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Protein
Submitted name:

Lactate dehydrogenase

Gene
N/A
Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40NADCombined sources1
Binding sitei101SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei156NAD; via carbonyl oxygenCombined sources1
Binding sitei164SubstrateUniRule annotation1
Active sitei188Proton acceptorUniRule annotation1
Binding sitei188NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 20NADCombined sources2
Nucleotide bindingi87 – 88NADCombined sources2
Nucleotide bindingi131 – 133NADCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.1.1.27. 6411.

Names & Taxonomyi

Protein namesi
Submitted name:
Lactate dehydrogenaseImported (EC:1.1.1.27Imported)
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

EuPathDBiToxoDB:TGME49_232350.

PTM / Processingi

PTM databases

SwissPalmiP90613.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZEX-ray1.95A1-329[»]
1PZFX-ray2.20A/B/C/D1-329[»]
1PZGX-ray1.60A/B/C/D1-329[»]
1PZHX-ray1.90A/B/C/D1-329[»]
3OM9X-ray1.98A/B/C/D3-329[»]
ProteinModelPortaliP90613.
SMRiP90613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 155Ldh_1_NInterPro annotationAdd BLAST145
Domaini160 – 317Ldh_1_CInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

P90613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPALVQRRK KVAMIGSGMI GGTMGYLCAL RELADVVLYD VVKGMPEGKA
60 70 80 90 100
LDLSHVTSVV DTNVSVRAEY SYEAALTGAD CVIVTAGLTK VPGKPDSEWS
110 120 130 140 150
RNDLLPFNSK IIREIGQNIK KYCPKTFIIV VTNPLDCMVK VMCEASGVPT
160 170 180 190 200
NMICGMACML DSGRFRRYVA DALSVSPRDV QATVIGTHGD CMVPLVRYIT
210 220 230 240 250
VNGYPIQKFI KDGVVTEKQL EEIAEHTKVS GGEIVRFLGQ GSAYYAPAAS
260 270 280 290 300
AVAMATSFLN DEKRVIPCSV YCNGEYGLKD MFIGLPAVIG GAGIERVIEL
310 320
ELNEEEKKQF QKSVDDVMAL NKAVAALQA
Length:329
Mass (Da):35,548
Last modified:May 1, 1997 - v1
Checksum:iF06387B5AC0E6BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35118 mRNA. Translation: AAC47443.1.

Similar proteinsi

Entry informationi

Entry nameiP90613_TOXGO
AccessioniPrimary (citable) accession number: P90613
Secondary accession number(s): A0A0N5EA41
, B6KJT2, B9PGJ8, B9Q4R1, S7WIY9, S8F2N7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources