Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Lactate dehydrogenase

Gene
N/A
Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401NADCombined sources
Binding sitei156 – 1561NAD; via carbonyl oxygenCombined sources
Active sitei188 – 1881Proton acceptorUniRule annotation
Binding sitei188 – 1881NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NADCombined sources
Nucleotide bindingi87 – 882NADCombined sources
Nucleotide bindingi131 – 1333NADCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.1.1.27. 6411.

Names & Taxonomyi

Protein namesi
Submitted name:
Lactate dehydrogenaseImported (EC:1.1.1.27Imported)
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

EuPathDBiToxoDB:TGME49_232350.

PTM / Processingi

PTM databases

SwissPalmiP90613.

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_032350.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZEX-ray1.95A1-329[»]
1PZFX-ray2.20A/B/C/D1-329[»]
1PZGX-ray1.60A/B/C/D1-329[»]
1PZHX-ray1.90A/B/C/D1-329[»]
3OM9X-ray1.98A/B/C/D3-329[»]
SMRiP90613. Positions 3-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
OMAiATIDTNP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

P90613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPALVQRRK KVAMIGSGMI GGTMGYLCAL RELADVVLYD VVKGMPEGKA
60 70 80 90 100
LDLSHVTSVV DTNVSVRAEY SYEAALTGAD CVIVTAGLTK VPGKPDSEWS
110 120 130 140 150
RNDLLPFNSK IIREIGQNIK KYCPKTFIIV VTNPLDCMVK VMCEASGVPT
160 170 180 190 200
NMICGMACML DSGRFRRYVA DALSVSPRDV QATVIGTHGD CMVPLVRYIT
210 220 230 240 250
VNGYPIQKFI KDGVVTEKQL EEIAEHTKVS GGEIVRFLGQ GSAYYAPAAS
260 270 280 290 300
AVAMATSFLN DEKRVIPCSV YCNGEYGLKD MFIGLPAVIG GAGIERVIEL
310 320
ELNEEEKKQF QKSVDDVMAL NKAVAALQA
Length:329
Mass (Da):35,548
Last modified:May 1, 1997 - v1
Checksum:iF06387B5AC0E6BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35118 mRNA. Translation: AAC47443.1.

Genome annotation databases

EnsemblProtistsiEPR64243; EPR64243; TGGT1_232350.
ESS35741; ESS35741; TGVEG_232350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35118 mRNA. Translation: AAC47443.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZEX-ray1.95A1-329[»]
1PZFX-ray2.20A/B/C/D1-329[»]
1PZGX-ray1.60A/B/C/D1-329[»]
1PZHX-ray1.90A/B/C/D1-329[»]
3OM9X-ray1.98A/B/C/D3-329[»]
SMRiP90613. Positions 3-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_032350.

PTM databases

SwissPalmiP90613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEPR64243; EPR64243; TGGT1_232350.
ESS35741; ESS35741; TGVEG_232350.

Organism-specific databases

EuPathDBiToxoDB:TGME49_232350.

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
OMAiATIDTNP.

Enzyme and pathway databases

BRENDAi1.1.1.27. 6411.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP90613_TOXGO
AccessioniPrimary (citable) accession number: P90613
Secondary accession number(s): A0A0N5EA41
, B6KJT2, B9PGJ8, B9Q4R1, S7WIY9, S8F2N7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.