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Protein

Tubulin gamma-2 chain

Gene
N/A
Organism
Euplotes octocarinatus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
OrganismiEuplotes octocarinatus
Taxonomic identifieri5937 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaHypotrichiaEuplotidaEuplotidaeEuplotes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Tubulin gamma-2 chainPRO_0000048463Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP90548.
SMRiP90548. Positions 2-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREIITCQV GQCGNQIGME FWKQLCMEHG INPEGILEDF AVNGEDRKDV
60 70 80 90 100
FFYQADDEHY VPRAVLIDLE PRVINGIQKS AYSSLYNPEN IYIAKHGGGA
110 120 130 140 150
GNNWGRGYTD AEKVQDEILE MIDREADGSD SLEGFVLTHS IAGGTGSGFG
160 170 180 190 200
SYLLERLNDH YPKKLIQTYS VFPIENDVVV QPYNCLLSIK RLTLNADCVV
210 220 230 240 250
VLDNNALTSI AVDRLKILQP TFSQINSIVS TVMAASTTTL RYPGYMNNDM
260 270 280 290 300
VGLIASLVPT PRCHFLMTGY TPLSLDQKFT SVRKTTVLDV MRRLLQTKNI
310 320 330 340 350
MVTGAVKKGA YMSILNVIQG DVDPTQVHKS LQRIRERKLA NFIPWGPASI
360 370 380 390 400
QVALSKKSPY IDSGHKVSGL MLANHTGIRS IFKVLYDQYR TFRKRDAYMN
410 420 430 440 450
IFKQTKIFED NLDEFDSSDE VVKSLIDEYA AAEKMDYINW GSDDDDMQFD
460
PREPPKFSNI Q
Length:461
Mass (Da):51,952
Last modified:May 1, 1997 - v1
Checksum:iDBED624C4B824A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09553 Genomic DNA. Translation: CAA70744.1.
Y17254 Genomic DNA. Translation: CAA76714.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09553 Genomic DNA. Translation: CAA70744.1.
Y17254 Genomic DNA. Translation: CAA76714.1.

3D structure databases

ProteinModelPortaliP90548.
SMRiP90548. Positions 2-440.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The two gamma tubulin genes of Euplotes octocarinatus code for a slightly different protein."
    Tan M., Liang A., Heckmann K.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTBG2_EUPOC
AccessioniPrimary (citable) accession number: P90548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.