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P90513 (PSA3_ACACA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-3

EC=3.4.25.1
OrganismAcanthamoeba castellanii (Amoeba)
Taxonomic identifier5755 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Protein attributes

Sequence length252 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 252›252Proteasome subunit alpha type-3
PRO_0000124094

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P90513 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 71898276B50C2E79

FASTA25227,728
        10         20         30         40         50         60 
SIGTGYDLSS TTFSPDGRVF QVEYAAKAVD NSGTALGLRV KDGVVLAVEK LLVSKMLVPN 

        70         80         90        100        110        120 
TNRRIHTVDR HCGLAMSGLV ADGRQLVSRG RAEATSYREF YGTDISGKVL NERLSNFVQL 

       130        140        150        160        170        180 
YSLYGSVRPF GTSVILGCVD KNGPQLYMIE PSGISWGYFG VAIGKGARAA KTEIEKLKLS 

       190        200        210        220        230        240 
EMTAREAIKE AAKIIYSVHD DAKDKAFELE LSWVCEETGN LHKFVPKDLL EEAEKYAKQA 

       250 
LEEEEDMSEE ED 

« Hide

References

[1]Xu P., Zot H.G.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U85398 mRNA. Translation: AAB41645.1.

3D structure databases

ProteinModelPortalP90513.
SMRP90513. Positions 1-243.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA3_ACACA
AccessionPrimary (citable) accession number: P90513
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries