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P90463 (TYSY_HHV8P) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:70
OrganismHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) [Reference proteome]
Taxonomic identifier868565 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000141065

Sites

Active site2191 By similarity

Sequences

Sequence LengthMass (Da)Tools
P90463 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: D0EB0CE60A3384EC

FASTA33738,555
        10         20         30         40         50         60 
MFPFVPLSLY VAKKLFRARG FRFCQKPGVL ALAPEVDPCS IQHEVTGAET PHEELQYLRQ 

        70         80         90        100        110        120 
LREILCRGSD RLDRTGIGTL SLFGMQARYS LRDHFPLLTT KRVFWRGVVQ ELLWFLKGST 

       130        140        150        160        170        180 
DSRELSRTGV KIWDKNGSRE FLAGRGLAHR REGDLGPVYG FQWRHFGAAY VDADADYTGQ 

       190        200        210        220        230        240 
GFDQLSYIVD LIKNNPHDRR IIMCAWNPAD LSLMALPPCH LLCQFYVADG ELSCQLYQRS 

       250        260        270        280        290        300 
GDMGLGVPFN IASYSLLTYM LAHVTGLRPG EFIHTLGDAH IYKTHIEPLR LQLTRTPRPF 

       310        320        330 
PRLEILRSVS SMEEFTPDDF RLVDYCPHPT IRMEMAV 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)."
Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S.
Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?"
Neipel F., Albrecht J.-C., Fleckenstein B.
J. Virol. 71:4187-4192(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75698 Genomic DNA. Translation: AAC57092.1.
U83348 Genomic DNA. Translation: AAC56948.1.
U93872 Genomic DNA. Translation: AAB62673.1.
U71365 Genomic DNA. Translation: AAC34940.1.
AF148805 Genomic DNA. Translation: ABD28859.1.
RefSeqYP_001129361.1. NC_009333.1.

3D structure databases

ProteinModelPortalP90463.
SMRP90463. Positions 51-337.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4961481.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_HHV8P
AccessionPrimary (citable) accession number: P90463
Secondary accession number(s): D0UZM0, Q2HRC4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways