P90463 (TYSY_HHV8P) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

Name:

70

Organism

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) [Reference proteome]

Taxonomic identifier

868565 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Human herpesvirus 8

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Thymidylate synthase		PRO_0000141065
Sites
	Active site	219	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P90463 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: D0EB0CE60A3384EC	FASTA	337	38,555
	10 20 30 40 50 60 MFPFVPLSLY VAKKLFRARG FRFCQKPGVL ALAPEVDPCS IQHEVTGAET PHEELQYLRQ 70 80 90 100 110 120 LREILCRGSD RLDRTGIGTL SLFGMQARYS LRDHFPLLTT KRVFWRGVVQ ELLWFLKGST 130 140 150 160 170 180 DSRELSRTGV KIWDKNGSRE FLAGRGLAHR REGDLGPVYG FQWRHFGAAY VDADADYTGQ 190 200 210 220 230 240 GFDQLSYIVD LIKNNPHDRR IIMCAWNPAD LSLMALPPCH LLCQFYVADG ELSCQLYQRS 250 260 270 280 290 300 GDMGLGVPFN IASYSLLTYM LAHVTGLRPG EFIHTLGDAH IYKTHIEPLR LQLTRTPRPF 310 320 330 PRLEILRSVS SMEEFTPDDF RLVDYCPHPT IRMEMAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?" Neipel F., Albrecht J.-C., Fleckenstein B. J. Virol. 71:4187-4192(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Kaposi's sarcoma-associated herpesvirus immune modulation: an overview." Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J. J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75698 Genomic DNA. Translation: AAC57092.1. U83348 Genomic DNA. Translation: AAC56948.1. U93872 Genomic DNA. Translation: AAB62673.1. U71365 Genomic DNA. Translation: AAC34940.1. AF148805 Genomic DNA. Translation: ABD28859.1.
RefSeq	YP_001129361.1. NC_009333.1.
3D structure databases
ProteinModelPortal	P90463.
SMR	P90463. Positions 51-337.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4961481.
Phylogenomic databases
ProtClustDB	CLSP2509595.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_HHV8P

Accession

Primary (citable) accession number: P90463
Secondary accession number(s): D0UZM0, Q2HRC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program