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Protein

Gag polyprotein

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

Host-virus interactionUniRule annotationSAAS annotation, Virus exit from host cellSAAS annotation

Keywords - Ligandi

Metal-binding, RNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotation
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP90248.
SMRiP90248. Positions 2-429, 484-995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini389 – 40416CCHC-typeInterPro annotationAdd
BLAST
Domaini411 – 42616CCHC-typeInterPro annotationAdd
BLAST
Domaini507 – 57670Peptidase A2InterPro annotationAdd
BLAST
Domaini630 – 820191Reverse transcriptaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili94 – 11724Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains CCHC-type zinc fingers.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR000721. Gag_p24.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P90248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG GKLDAWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPSL
60 70 80 90 100
LETTEGCQQI MEQLQSALRT GTEELRSLYN TVATLYCVHQ RIEVKDTKEA
110 120 130 140 150
LDKIEEIQKK SKQKTQQAAA DTGSSSKVSQ NYPIVQNAQG QMIHQSLSPR
160 170 180 190 200
TLNAWVKVIE EKALSPEVIP MFSALSEGAT PQDLNMMLNI VGGHQAAMQM
210 220 230 240 250
LKDTINEEAA EWDRLHPVHA GPVAPGQMRE PRGSDIAGTT STPQEQIAWM
260 270 280 290 300
TGNPPIPVGD IYKRWMILGL NKIVRMYSPV SILDIKQGPK EPFRDYVDRF
310 320 330 340 350
FKTLRAEQAT QEVKGWMTET LLIQNANPDC KSILRALGAG ATLEEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQV QHTNIMMQRG NFKGQKRIKC FNCGKEGHLA
410 420 430 440 450
KNCRAPRKKG CWKCGREGHQ MKDCTERQAK FFRENLAFQQ REARKFSSEQ
460 470 480 490 500
TRTNSPTSSR DLWDEGRDSL PSEAGAERQG PEPTFSFPQI TLWQRPLVTV
510 520 530 540 550
KIGGQLKKAL LDTGADDTVL EDINLPGKWK PKMIGGIGGF IKVKQYDQIL
560 570 580 590 600
IEICGKKAIG TVLVGPTPVN IIGRNMLTLI GCTLNFPISP ISTVPVKLKP
610 620 630 640 650
GMDGPRIKQW PLTEEKIKAL TEICADMERE GRISKIGPEN PYNTPIFAIK
660 670 680 690 700
KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA
710 720 730 740 750
YFSVPLDESF RKYTAFTIPS TNNETPGIRY QYNVLPQGWK GSPAIFQASM
760 770 780 790 800
TKILEPFRSK NPDIVIYQYM DDLYVGSDLE IGQHRTKIEE LREHLLKWGF
810 820 830 840 850
TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI ELPEKESWTV NDIQKLVGKL
860 870 880 890 900
NWASQIYAGI KVKQLCKLLR GTKALTDIVT LTEEAELELA ENREILKDPV
910 920 930 940 950
HGAYYDPSKD LIAEIQKQGQ DQWIYQIYQE PFKNLKTGKY ARKRSAHTND
960 970 980 990
VKQLAEVVQK VVMESIVIWG KTPKFKLPIQ KETWETWWMD YWQAT
Length:995
Mass (Da):112,846
Last modified:January 1, 1998 - v2
Checksum:i1BB0F0A96B5C7A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51190 Genomic DNA. Translation: AAC97542.1.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51190 Genomic DNA. Translation: AAC97542.1.

3D structure databases

ProteinModelPortaliP90248.
SMRiP90248. Positions 2-429, 484-995.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR000721. Gag_p24.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP90248_9HIV1
AccessioniPrimary (citable) accession number: P90248
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.