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Protein

Gag polyprotein

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseSAAS annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nuclease, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-bindingUniRule annotationSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase, Viral nucleoproteinUniRule annotation
Biological processEukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusSAAS annotation, Host gene expression shutoff by virus, Host-virus interaction, Viral penetration into host nucleusSAAS annotation, Viral release from host cell, Virion maturationSAAS annotation, Virus entry into host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000115858 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cell membrane SAAS annotation; Lipid-anchor SAAS annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cell membraneSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host membrane, Host nucleusUniRule annotationSAAS annotation, Membrane, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP90248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini389 – 404CCHC-typeInterPro annotationAdd BLAST16
Domaini411 – 426CCHC-typeInterPro annotationAdd BLAST16
Domaini507 – 576Peptidase A2InterPro annotationAdd BLAST70
Domaini630 – 820Reverse transcriptaseInterPro annotationAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 117Sequence analysisAdd BLAST24
Coiled coili422 – 442Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di1.10.1200.30, 1 hit
1.10.150.90, 1 hit
1.10.375.10, 1 hit
2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR000721 Gag_p24
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit
PS50158 ZF_CCHC, 2 hits

Sequencei

Sequence statusi: Complete.

P90248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG GKLDAWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPSL
60 70 80 90 100
LETTEGCQQI MEQLQSALRT GTEELRSLYN TVATLYCVHQ RIEVKDTKEA
110 120 130 140 150
LDKIEEIQKK SKQKTQQAAA DTGSSSKVSQ NYPIVQNAQG QMIHQSLSPR
160 170 180 190 200
TLNAWVKVIE EKALSPEVIP MFSALSEGAT PQDLNMMLNI VGGHQAAMQM
210 220 230 240 250
LKDTINEEAA EWDRLHPVHA GPVAPGQMRE PRGSDIAGTT STPQEQIAWM
260 270 280 290 300
TGNPPIPVGD IYKRWMILGL NKIVRMYSPV SILDIKQGPK EPFRDYVDRF
310 320 330 340 350
FKTLRAEQAT QEVKGWMTET LLIQNANPDC KSILRALGAG ATLEEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQV QHTNIMMQRG NFKGQKRIKC FNCGKEGHLA
410 420 430 440 450
KNCRAPRKKG CWKCGREGHQ MKDCTERQAK FFRENLAFQQ REARKFSSEQ
460 470 480 490 500
TRTNSPTSSR DLWDEGRDSL PSEAGAERQG PEPTFSFPQI TLWQRPLVTV
510 520 530 540 550
KIGGQLKKAL LDTGADDTVL EDINLPGKWK PKMIGGIGGF IKVKQYDQIL
560 570 580 590 600
IEICGKKAIG TVLVGPTPVN IIGRNMLTLI GCTLNFPISP ISTVPVKLKP
610 620 630 640 650
GMDGPRIKQW PLTEEKIKAL TEICADMERE GRISKIGPEN PYNTPIFAIK
660 670 680 690 700
KKDSTKWRKL VDFRELNKRT QDFWEVQLGI PHPAGLKKKK SVTVLDVGDA
710 720 730 740 750
YFSVPLDESF RKYTAFTIPS TNNETPGIRY QYNVLPQGWK GSPAIFQASM
760 770 780 790 800
TKILEPFRSK NPDIVIYQYM DDLYVGSDLE IGQHRTKIEE LREHLLKWGF
810 820 830 840 850
TTPDKKHQKE PPFLWMGYEL HPDKWTVQPI ELPEKESWTV NDIQKLVGKL
860 870 880 890 900
NWASQIYAGI KVKQLCKLLR GTKALTDIVT LTEEAELELA ENREILKDPV
910 920 930 940 950
HGAYYDPSKD LIAEIQKQGQ DQWIYQIYQE PFKNLKTGKY ARKRSAHTND
960 970 980 990
VKQLAEVVQK VVMESIVIWG KTPKFKLPIQ KETWETWWMD YWQAT
Length:995
Mass (Da):112,846
Last modified:January 1, 1998 - v2
Checksum:i1BB0F0A96B5C7A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51190 Genomic DNA Translation: AAC97542.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiP90248_9HIV1
AccessioniPrimary (citable) accession number: P90248
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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