P89951 (HBEAG_HBVGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
External core antigen

Alternative name(s):
HBeAg
Precore protein

Gene names

Name:

C

Organism

Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn) [Complete proteome]

Taxonomic identifier

489544 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Hepadnaviridae › Orthohepadnavirus

Virus host

Hylobatidae (gibbons) [TaxID: 9577]

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May regulate immune response to the intracellular capsid in acting as a T cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T cells By similarity.
Subunit structure	Homodimerizes By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	Phosphorylated By similarity. Cleaved by host furin By similarity.
Sequence similarities	Belongs to the orthohepadnavirus precore antigen family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral immunoevasion
Cellular component	Secreted
Coding sequence diversity	Alternative initiation
Domain	Repeat Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform External core antigen (identifier: P89951-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Capsid protein (identifier: P0C6I8-1)

The sequence of this isoform can be found in the external entry P0C6I8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 183	164	External core antigen		PRO_5000144855
	Propeptide	184 – 212	29	By similarity		PRO_0000324736
Regions
	Repeat	184 – 190	7	1; half-length
	Repeat	191 – 198	8	2
	Repeat	199 – 206	8	3
	Region	184 – 206	23	3 X 8 AA repeats of S-P-R-R-R-R-S-Q
Sites
	Site	183 – 184	2	Cleavage; by host By similarity
Amino acid modifications
	Disulfide bond	77		Interchain By similarity
	Disulfide bond	90		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform External core antigen [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 8B618DE2120E7AFB	FASTA	212	24,093
	10 20 30 40 50 60 MQLFHLCLII SCSCPTVQAS KLCLGWLLGM DIDPYKEFGA SVELLSFLPS DFFPSVRDLL 70 80 90 100 110 120 DTASALYREA LESPEHCSPN HTALRQAVLC WGELMTGCSW VGNNLEDPAS RELVVNYVNT 130 140 150 160 170 180 NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR 190 200 210 RGRSPRRRTP SPRRRRSQSP RRRRSQSPAS QC
	Isoform Capsid protein [UniParc]. See P0C6I8.		–	–

References

[1]	"Complete sequencing of a gibbon hepatitis B virus genome reveals a unique genotype distantly related to the chimpanzee hepatitis B virus." Norder H., Ebert J.W., Fields H.A., Mushahwar I.K., Magnius L.O. Virology 218:214-223(1996) [PubMed: 8615024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U46935 Genomic DNA. Translation: AAB41950.1.
PIR	S67504.
3D structure databases
ProteinModelPortal	P89951.
SMR	P89951. Positions 30-172.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013195. Hepatitis_B_virus_capsid_N. IPR002006. Viral_capsid_core_Hepatitis. [Graphical view]
Pfam	PF08290. Hep_core_N. 1 hit. PF00906. Hepatitis_core. 1 hit. [Graphical view]
ProDom	PD000874. Vir_capsid_Znf-put_N_Hepatitis. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47852. Viral_capsid_core_Hepatitis. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HBEAG_HBVGB

Accession

Primary (citable) accession number: P89951

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 1, 1997
Last modified:	September 21, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program