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Protein
Submitted name:

Bcl-2 homolog (Gene 16?)

Gene

v-bcl-2

Organism
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-2 homolog (Gene 16?)Imported
Submitted name:
M11Imported
Submitted name:
M11 proteinImported
Submitted name:
V-bcl-2Imported
Gene namesi
Name:v-bcl-2Imported
Synonyms:GAMMAHV.M11Imported, M11Imported
OrganismiMurid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)Imported
Taxonomic identifieri33708 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiApodemus sylvaticus (European woodmouse) [TaxID: 10129]

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 – 29Interchain (with C-104)Combined sources
Disulfide bondi104 – 104InterchainCombined sources
Disulfide bondi104 – 104Interchain (with C-29)Combined sources

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144574EBI-8849581,EBI-949378From a different organism.

Protein-protein interaction databases

DIPiDIP-47218N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ABONMR-A1-136[»]
3BL2X-ray2.30A/B5-135[»]
3DVUX-ray2.50A/B2-136[»]
4MI8X-ray2.10A/B2-136[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR029450. Apo_reg_M11.
[Graphical view]
PfamiPF15286. Bcl-2_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P89884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKKSGTYW ATLITAFLKT VSKVEELDCV DSAVLVDVSK IITLTQEFRR
60 70 80 90 100
HYDSVYRADY GPALKNWKRD LSKLFTSLFV DVINSGRIVG FFDVGRYVCE
110 120 130 140 150
EVLCPGSWTE DHELLNDCMT HFFIENNLMN HFPLEDIFLA QRKFQTTGFT
160 170
FLLHALAKVL PRIYSGNVIY V
Length:171
Mass (Da):19,743
Last modified:May 1, 1997 - v1
Checksum:i43937262635E3446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91858 Genomic DNA. Translation: AAB50016.1.
U97553 Genomic DNA. Translation: AAB66423.1.
AF105037 Genomic DNA. Translation: AAF19336.1.
GQ421301 Genomic DNA. Translation: ACV65512.1.
RefSeqiNP_044912.1. NC_001826.2.

Genome annotation databases

GeneIDi1497180.
KEGGivg:1497180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91858 Genomic DNA. Translation: AAB50016.1.
U97553 Genomic DNA. Translation: AAB66423.1.
AF105037 Genomic DNA. Translation: AAF19336.1.
GQ421301 Genomic DNA. Translation: ACV65512.1.
RefSeqiNP_044912.1. NC_001826.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ABONMR-A1-136[»]
3BL2X-ray2.30A/B5-135[»]
3DVUX-ray2.50A/B2-136[»]
4MI8X-ray2.10A/B2-136[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47218N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1497180.
KEGGivg:1497180.

Family and domain databases

InterProiIPR029450. Apo_reg_M11.
[Graphical view]
PfamiPF15286. Bcl-2_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic content and preliminary transcriptional analysis of a representative region of murine gammaherpesvirus 68."
    Mackett M., Stewart J.P., de V Pepper S., Chee M., Efstathiou S., Nash A.A., Arrand J.R.
    J. Gen. Virol. 78:1425-1433(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  2. "Complete sequence and genomic analysis of murine gammaherpesvirus 68."
    Virgin H.W., Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., Speck S.H.
    J. Virol. 71:5894-5904(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported and WUMSImported.
  3. "Murine herpesvirus type 68 homologues of cyclin and bcl-2."
    Burns W.H., Towne D.L., Sandford G.R.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Genetic content of murine gammaherpesviruses."
    Milligan S., Efstathiou S., Stewart J.P., Nash A.A., Davison A.J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  5. "A surface groove essential for viral Bcl-2 function during chronic infection in vivo."
    Loh J., Huang Q., Petros A.M., Nettesheim D., van Dyk L.F., Labrada L., Speck S.H., Levine B., Olejniczak E.T., Virgin H.W.
    PLoS Pathog. 1:e10-e10(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-136.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WUMSImported.
  7. "Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11."
    Sinha S., Colbert C.L., Becker N., Wei Y., Levine B.
    Autophagy 4:989-997(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-136.
  8. "Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68."
    Ku B., Woo J.S., Liang C., Lee K.H., Hong H.S., E X., Kim K.S., Jung J.U., Oh B.H.
    PLoS Pathog. 4:E25-E25(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 5-135, DISULFIDE BONDS.
  9. "Partial sequence and analysis of Murine herpesvirus strain 4556 (MHV4556) genome."
    Halasova Z., Valovicova M., Belvoncikova P., Pancik P., Rezuchova I., Kudelova M.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 4556Imported.
  10. "Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy."
    Su M., Mei Y., Sanishvili R., Levine B., Colbert C.L., Sinha S.
    J. Biol. Chem. 289:8029-8040(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-136, DISULFIDE BONDS.

Entry informationi

Entry nameiP89884_MHV68
AccessioniPrimary (citable) accession number: P89884
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.