P89681 (CAPSD_VESVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsid protein
Short name=CP

Alternative name(s):
Coat protein
VP1

Gene names

ORF Names:

ORF2

Organism

Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) [Reference proteome]

Taxonomic identifier

85617 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Vesivirus › Vesicular exanthema of swine virus

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	701 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and VP2 proteins. Attaches virion to target cells. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.
Subunit structure	Homodimer. Homomultimer. May bind to VP3 and Vpg proteins By similarity.
Subcellular location	Virion. Host cytoplasm By similarity.
Post-translational modification	Cleaved by virus calcivirin to produce mature capsid protein By similarity.
Sequence similarities	Belongs to the caliciviridae capsid protein family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Molecular function	Capsid protein T=3 icosahedral capsid protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	T=3 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 152	152	By similarity		PRO_0000402463
	Chain	153 – 701	549	Capsid protein		PRO_0000402464

Sequences

	Sequence		Length	Mass (Da)
	P89681 [UniParc]. Last modified March 1, 2001. Version 3. Checksum: BE8FCFD9D44DF62A	FASTA	701	77,477
	10 20 30 40 50 60 MATTHTLLSF DNLEFLLHRK DLTDLYGKRC GTLNLVINPY ELFLPDELDD DCCDDPFNCC 70 80 90 100 110 120 FSDVYASIGT EYSYIDPPDL IYEEHCATNG TWPDGTPCEP ILPPFTITGT HHYYATKPGE 130 140 150 160 170 180 VVSGILSKLR VFLGSLLRST ADVNSNFTFR AESDGPGSTE IVTEEQGTIV QQQPAPAPTA 190 200 210 220 230 240 LATLATASTG KSVEQEWMTF FSYHTSINWS TVESQGKVLY SQALNPSINP YLDHISKLYS 250 260 270 280 290 300 TWSGGIDVRF TVSGSGVFGG KLAALLVPPG VEPIESVSML QYPHVLFDAR QTEPVIFTIP 310 320 330 340 350 360 DIRKTLFHSM DETDTTKLVI MVYKNGADTK TTCSITVETR PSADFTFALL KPPGSLIKHG 370 380 390 400 410 420 SIPSDLIPRN SAHWLGNRWW SMISGFSVQP RVFQSNRHFD FDSTTTGWST PYYIPIEITI 430 440 450 460 470 480 TAKVKGNNHW YHVIAHDKAL VPGIPDGWPD TTIPSEVHAS NGNFDYAKGF HDDKEIVNPA 490 500 510 520 530 540 NNNTHFKGTY ICGTLSTIKD PEKAENQSES QKKSSTMYVA TADLGDNKVK PQHKISSQKL 550 560 570 580 590 600 VVYFDGPEKD LTMNATLSPL GYTLVDDQPI GSNSSTVVRI ATLPEAFTQG GNYPIFYVNK 610 620 630 640 650 660 TNKGYFDKAT TDCYNSQILM TSQRLAEGNY SLPPDSLAVY RITDSSSQWF DIGINHDGFS 670 680 690 700 YVGLPDLPAD LTFPLTSTFM GVQLARVKLA SKVKVTRNSI K

References

[1]	"The capsid protein of vesicular exanthema of swine virus serotype A48: relationship to the capsid protein of other animal caliciviruses." Neill J.D., Meyer R.F., Seal B.S. Virus Res. 54:39-50(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Complete nucleotide sequence of the genomic RNA of vesicular exanthema of swine virus A48." Neill J.D., Seal B.S., Ridpath J.F. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U76874 Genomic RNA. Translation: AAC13889.2.
RefSeq	NP_066256.1. NC_002551.1.
3D structure databases
ProteinModelPortal	P89681.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911832.
Family and domain databases
InterPro	IPR004005. Calicivirus_coat. [Graphical view]
Pfam	PF00915. Calici_coat. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPSD_VESVA

Accession

Primary (citable) accession number: P89681

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 42 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program