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P89681

- CAPSD_VESVA

UniProt

P89681 - CAPSD_VESVA

Protein

Capsid protein

Gene

ORF2

Organism
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 3 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and VP2 proteins. Attaches virion to target cells. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein
    Short name:
    CP
    Alternative name(s):
    Coat protein
    VP1
    Gene namesi
    ORF Names:ORF2
    OrganismiVesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV)
    Taxonomic identifieri85617 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000007661: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. T=3 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 152152By similarityPRO_0000402463Add
    BLAST
    Chaini153 – 701549Capsid proteinPRO_0000402464Add
    BLAST

    Post-translational modificationi

    Cleaved by virus calcivirin to produce mature capsid protein.By similarity

    Interactioni

    Subunit structurei

    Homodimer. Homomultimer. May bind to VP3 and Vpg proteins By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP89681.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    InterProiIPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P89681-1 [UniParc]FASTAAdd to Basket

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    MATTHTLLSF DNLEFLLHRK DLTDLYGKRC GTLNLVINPY ELFLPDELDD    50
    DCCDDPFNCC FSDVYASIGT EYSYIDPPDL IYEEHCATNG TWPDGTPCEP 100
    ILPPFTITGT HHYYATKPGE VVSGILSKLR VFLGSLLRST ADVNSNFTFR 150
    AESDGPGSTE IVTEEQGTIV QQQPAPAPTA LATLATASTG KSVEQEWMTF 200
    FSYHTSINWS TVESQGKVLY SQALNPSINP YLDHISKLYS TWSGGIDVRF 250
    TVSGSGVFGG KLAALLVPPG VEPIESVSML QYPHVLFDAR QTEPVIFTIP 300
    DIRKTLFHSM DETDTTKLVI MVYKNGADTK TTCSITVETR PSADFTFALL 350
    KPPGSLIKHG SIPSDLIPRN SAHWLGNRWW SMISGFSVQP RVFQSNRHFD 400
    FDSTTTGWST PYYIPIEITI TAKVKGNNHW YHVIAHDKAL VPGIPDGWPD 450
    TTIPSEVHAS NGNFDYAKGF HDDKEIVNPA NNNTHFKGTY ICGTLSTIKD 500
    PEKAENQSES QKKSSTMYVA TADLGDNKVK PQHKISSQKL VVYFDGPEKD 550
    LTMNATLSPL GYTLVDDQPI GSNSSTVVRI ATLPEAFTQG GNYPIFYVNK 600
    TNKGYFDKAT TDCYNSQILM TSQRLAEGNY SLPPDSLAVY RITDSSSQWF 650
    DIGINHDGFS YVGLPDLPAD LTFPLTSTFM GVQLARVKLA SKVKVTRNSI 700
    K 701
    Length:701
    Mass (Da):77,477
    Last modified:March 1, 2001 - v3
    Checksum:iBE8FCFD9D44DF62A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76874 Genomic RNA. Translation: AAC13889.2.
    RefSeqiNP_066256.1. NC_002551.1.

    Genome annotation databases

    GeneIDi911832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76874 Genomic RNA. Translation: AAC13889.2 .
    RefSeqi NP_066256.1. NC_002551.1.

    3D structure databases

    ProteinModelPortali P89681.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 911832.

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    InterProi IPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The capsid protein of vesicular exanthema of swine virus serotype A48: relationship to the capsid protein of other animal caliciviruses."
      Neill J.D., Meyer R.F., Seal B.S.
      Virus Res. 54:39-50(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Complete nucleotide sequence of the genomic RNA of vesicular exanthema of swine virus A48."
      Neill J.D., Seal B.S., Ridpath J.F.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiCAPSD_VESVA
    AccessioniPrimary (citable) accession number: P89681
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 45 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3