Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Capsid protein

Gene

ORF2

Organism
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and VP2 proteins. Attaches virion to target cells. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
VP1
Gene namesi
ORF Names:ORF2
OrganismiVesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV)
Taxonomic identifieri85617 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000007661 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 152152By similarityPRO_0000402463Add
BLAST
Chaini153 – 701549Capsid proteinPRO_0000402464Add
BLAST

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein.By similarity

Interactioni

Subunit structurei

Homodimer. Homomultimer. May bind to VP3 and Vpg proteins (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP89681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P89681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTHTLLSF DNLEFLLHRK DLTDLYGKRC GTLNLVINPY ELFLPDELDD
60 70 80 90 100
DCCDDPFNCC FSDVYASIGT EYSYIDPPDL IYEEHCATNG TWPDGTPCEP
110 120 130 140 150
ILPPFTITGT HHYYATKPGE VVSGILSKLR VFLGSLLRST ADVNSNFTFR
160 170 180 190 200
AESDGPGSTE IVTEEQGTIV QQQPAPAPTA LATLATASTG KSVEQEWMTF
210 220 230 240 250
FSYHTSINWS TVESQGKVLY SQALNPSINP YLDHISKLYS TWSGGIDVRF
260 270 280 290 300
TVSGSGVFGG KLAALLVPPG VEPIESVSML QYPHVLFDAR QTEPVIFTIP
310 320 330 340 350
DIRKTLFHSM DETDTTKLVI MVYKNGADTK TTCSITVETR PSADFTFALL
360 370 380 390 400
KPPGSLIKHG SIPSDLIPRN SAHWLGNRWW SMISGFSVQP RVFQSNRHFD
410 420 430 440 450
FDSTTTGWST PYYIPIEITI TAKVKGNNHW YHVIAHDKAL VPGIPDGWPD
460 470 480 490 500
TTIPSEVHAS NGNFDYAKGF HDDKEIVNPA NNNTHFKGTY ICGTLSTIKD
510 520 530 540 550
PEKAENQSES QKKSSTMYVA TADLGDNKVK PQHKISSQKL VVYFDGPEKD
560 570 580 590 600
LTMNATLSPL GYTLVDDQPI GSNSSTVVRI ATLPEAFTQG GNYPIFYVNK
610 620 630 640 650
TNKGYFDKAT TDCYNSQILM TSQRLAEGNY SLPPDSLAVY RITDSSSQWF
660 670 680 690 700
DIGINHDGFS YVGLPDLPAD LTFPLTSTFM GVQLARVKLA SKVKVTRNSI

K
Length:701
Mass (Da):77,477
Last modified:March 1, 2001 - v3
Checksum:iBE8FCFD9D44DF62A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76874 Genomic RNA. Translation: AAC13889.2.
RefSeqiNP_066256.1. NC_002551.1.

Genome annotation databases

GeneIDi911832.
KEGGivg:911832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76874 Genomic RNA. Translation: AAC13889.2.
RefSeqiNP_066256.1. NC_002551.1.

3D structure databases

ProteinModelPortaliP89681.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi911832.
KEGGivg:911832.

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The capsid protein of vesicular exanthema of swine virus serotype A48: relationship to the capsid protein of other animal caliciviruses."
    Neill J.D., Meyer R.F., Seal B.S.
    Virus Res. 54:39-50(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Complete nucleotide sequence of the genomic RNA of vesicular exanthema of swine virus A48."
    Neill J.D., Seal B.S., Ridpath J.F.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiCAPSD_VESVA
AccessioniPrimary (citable) accession number: P89681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 48 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.