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P89681 (CAPSD_VESVA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsid protein

Short name=CP
Alternative name(s):
Coat protein
VP1
Gene names
ORF Names:ORF2
OrganismVesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) [Reference proteome]
Taxonomic identifier85617 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length701 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and VP2 proteins. Attaches virion to target cells. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Subunit structure

Homodimer. Homomultimer. May bind to VP3 and Vpg proteins By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Post-translational modification

Cleaved by virus calcivirin to produce mature capsid protein By similarity.

Sequence similarities

Belongs to the caliciviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 152152 By similarity
PRO_0000402463
Chain153 – 701549Capsid protein
PRO_0000402464

Sequences

Sequence LengthMass (Da)Tools
P89681 [UniParc].

Last modified March 1, 2001. Version 3.
Checksum: BE8FCFD9D44DF62A

FASTA70177,477
        10         20         30         40         50         60 
MATTHTLLSF DNLEFLLHRK DLTDLYGKRC GTLNLVINPY ELFLPDELDD DCCDDPFNCC 

        70         80         90        100        110        120 
FSDVYASIGT EYSYIDPPDL IYEEHCATNG TWPDGTPCEP ILPPFTITGT HHYYATKPGE 

       130        140        150        160        170        180 
VVSGILSKLR VFLGSLLRST ADVNSNFTFR AESDGPGSTE IVTEEQGTIV QQQPAPAPTA 

       190        200        210        220        230        240 
LATLATASTG KSVEQEWMTF FSYHTSINWS TVESQGKVLY SQALNPSINP YLDHISKLYS 

       250        260        270        280        290        300 
TWSGGIDVRF TVSGSGVFGG KLAALLVPPG VEPIESVSML QYPHVLFDAR QTEPVIFTIP 

       310        320        330        340        350        360 
DIRKTLFHSM DETDTTKLVI MVYKNGADTK TTCSITVETR PSADFTFALL KPPGSLIKHG 

       370        380        390        400        410        420 
SIPSDLIPRN SAHWLGNRWW SMISGFSVQP RVFQSNRHFD FDSTTTGWST PYYIPIEITI 

       430        440        450        460        470        480 
TAKVKGNNHW YHVIAHDKAL VPGIPDGWPD TTIPSEVHAS NGNFDYAKGF HDDKEIVNPA 

       490        500        510        520        530        540 
NNNTHFKGTY ICGTLSTIKD PEKAENQSES QKKSSTMYVA TADLGDNKVK PQHKISSQKL 

       550        560        570        580        590        600 
VVYFDGPEKD LTMNATLSPL GYTLVDDQPI GSNSSTVVRI ATLPEAFTQG GNYPIFYVNK 

       610        620        630        640        650        660 
TNKGYFDKAT TDCYNSQILM TSQRLAEGNY SLPPDSLAVY RITDSSSQWF DIGINHDGFS 

       670        680        690        700 
YVGLPDLPAD LTFPLTSTFM GVQLARVKLA SKVKVTRNSI K 

« Hide

References

[1]"The capsid protein of vesicular exanthema of swine virus serotype A48: relationship to the capsid protein of other animal caliciviruses."
Neill J.D., Meyer R.F., Seal B.S.
Virus Res. 54:39-50(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Complete nucleotide sequence of the genomic RNA of vesicular exanthema of swine virus A48."
Neill J.D., Seal B.S., Ridpath J.F.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U76874 Genomic RNA. Translation: AAC13889.2.
RefSeqNP_066256.1. NC_002551.1.

3D structure databases

ProteinModelPortalP89681.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911832.

Family and domain databases

Gene3D2.60.120.20. 1 hit.
InterProIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_VESVA
AccessionPrimary (citable) accession number: P89681
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families