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Protein

Genome polyprotein

Gene
N/A
Organism
Turnip mosaic virus (strain Japanese) (TuMV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
Nuclear inclusion protein A: has RNA-binding and proteolytic activities.

Catalytic activityi

Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei270 – 2701For P1 proteinase activityBy similarity
Active sitei279 – 2791For P1 proteinase activitySequence analysis
Active sitei313 – 3131For P1 proteinase activityBy similarity
Active sitei706 – 7061For helper component proteinase activityPROSITE-ProRule annotation
Active sitei779 – 7791For helper component proteinase activityPROSITE-ProRule annotation
Active sitei2162 – 21621For nuclear inclusion protein A activityPROSITE-ProRule annotation
Active sitei2197 – 21971For nuclear inclusion protein A activityPROSITE-ProRule annotation
Active sitei2267 – 22671For nuclear inclusion protein A activityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1313 – 13208ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Suppressor of RNA silencing, Thiol protease, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
OrganismiTurnip mosaic virus (strain Japanese) (TuMV)
Taxonomic identifieri12230 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePotyviridaePotyvirus
Virus hostiAlliaria petiolata (Garlic mustard) (Arabis petiolata) [TaxID: 126270]
Brassica [TaxID: 3705]
Calanthe [TaxID: 38206]
Capsella bursa-pastoris (Shepherd's purse) (Thlaspi bursa-pastoris) [TaxID: 3719]
Hesperis matronalis [TaxID: 264418]
Stellaria media (Common chickweed) (Alsine media) [TaxID: 13274]
Trifolium hybridum (Alsike clover) [TaxID: 74517]
Proteomesi
  • UP000008262 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31643164Genome polyproteinPRO_0000420029Add
BLAST
Chaini1 – 362362P1 proteinaseSequence analysisPRO_0000040463Add
BLAST
Chaini363 – 820458Helper component proteinaseSequence analysisPRO_0000040464Add
BLAST
Chaini821 – 1175355Protein P3By similarityPRO_0000040465Add
BLAST
Chaini1176 – 1227526 kDa protein 1By similarityPRO_0000040466Add
BLAST
Chaini1228 – 1871644Cytoplasmic inclusion proteinBy similarityPRO_0000040467Add
BLAST
Chaini1872 – 1924536 kDa protein 2By similarityPRO_0000040468Add
BLAST
Chaini1925 – 2116192Viral genome-linked proteinBy similarityPRO_0000040469Add
BLAST
Chaini2117 – 2359243Nuclear inclusion protein ABy similarityPRO_0000040470Add
BLAST
Chaini2360 – 2876517Nuclear inclusion protein BBy similarityPRO_0000040471Add
BLAST
Chaini2877 – 3164288Capsid proteinBy similarityPRO_0000040472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1987 – 19871O-(5'-phospho-RNA)-tyrosineBy similarity

Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3632Cleavage; by P1 proteinaseSequence analysis
Sitei820 – 8212Cleavage; by autolysisPROSITE-ProRule annotation
Sitei1175 – 11762Cleavage; by NIa-proBy similarity
Sitei1227 – 12282Cleavage; by NIa-proBy similarity
Sitei1871 – 18722Cleavage; by NIa-proBy similarity
Sitei1924 – 19252Cleavage; by NIa-proBy similarity
Sitei2116 – 21172Cleavage; by NIa-proBy similarity
Sitei2359 – 23602Cleavage; by NIa-proBy similarity
Sitei2876 – 28772Cleavage; by NIa-proBy similarity

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Structurei

Secondary structure

1
3164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi708 – 7147Combined sources
Helixi715 – 7173Combined sources
Helixi720 – 7223Combined sources
Helixi723 – 73210Combined sources
Helixi734 – 7385Combined sources
Helixi744 – 75714Combined sources
Helixi759 – 7635Combined sources
Beta strandi768 – 7725Combined sources
Turni773 – 7764Combined sources
Beta strandi777 – 7815Combined sources
Beta strandi784 – 7863Combined sources
Beta strandi788 – 7903Combined sources
Helixi799 – 8079Combined sources
Beta strandi808 – 8103Combined sources
Helixi813 – 8164Combined sources
Beta strandi817 – 8193Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RNVX-ray2.00A663-820[»]
ProteinModelPortaliP89509.
SMRiP89509. Positions 2125-2338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini698 – 820123Peptidase C6PROSITE-ProRule annotationAdd
BLAST
Domaini1300 – 1452153Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1471 – 1630160Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini2117 – 2335219Peptidase C4PROSITE-ProRule annotationAdd
BLAST
Domaini2601 – 2725125RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4174Involved in interaction with stylet and aphid transmissionBy similarity
Motifi672 – 6743Involved in virions binding and aphid transmissionBy similarity
Motifi1402 – 14054DECH box
Motifi1965 – 19728Nuclear localization signalSequence analysis

Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 peptidase C4 domain.PROSITE-ProRule annotation
Contains 1 peptidase C6 domain.PROSITE-ProRule annotationCurated
Contains 1 peptidase S30 domain.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform Genome polyprotein (identifier: P89509-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVTFATAI TNTTASKPAL TGMIQFGNFP PVPLRSTTVT TVATSVAQPK
60 70 80 90 100
LHTVQFGSLD PVVVKSGAGS FAKATRQQPN VEIDVSLSEA AALEVAKPRP
110 120 130 140 150
NAVLRMHEEA NKERALFLDW EASLKRSSYG IAENEKVVMT TRGVSKIVPR
160 170 180 190 200
SSGAMKQKRA RERRRAQQPI ILKWEPKLSG ISIGGGLSAS AIEVEEARTK
210 220 230 240 250
WPLHKTPSMK RKTVHRRCKM NDQGIDMLMR SLIKIFKAKS ANIEFIGRKS
260 270 280 290 300
IKVDFVKKEQ TKFARVQVVH LLGKRAQRDL STGMEENHFI DILSGYSGNK
310 320 330 340 350
TTINPGVVCA GWSGIVVRDG ILTQKRSRSP SEAFVIRGEH EGKLYDARIK
360 370 380 390 400
ITRTMSHKIV HFSAAGANFW KGFDRCFLAY RSDNREHTCY SGLDVTECGE
410 420 430 440 450
VAALMCLAMF PCGKITCPDC VTDSELSQGQ ASGPSMKHRL VQLRDVIKSS
460 470 480 490 500
YPRFKHAVQI LDRYEQSLRS ANENYQDFAE IQSISDGVEK AAFPHVNKLN
510 520 530 540 550
AILIKGATAT GEEFSQATKH LLEIARYLKN RTENIEKGSL KSFRNKISQK
560 570 580 590 600
AHINPTLMCD NQLDRNGNFI WGERGYHAKR FFSNYFEIID PKKGYTQYET
610 620 630 640 650
RVVPNGSRKL AIGKLIVPTN FEVLREQMKG EPVEPYPVTV ECVSKLQGDF
660 670 680 690 700
VHACCCVTTE SGDPVLSEIK MPTKHHLVIG NSGDPKYIDL PEIEENKMYI
710 720 730 740 750
AKEGYCYINI FLAMLVNVKE SQAKEFTKVV RDKLVGELGK WPTLLDVATA
760 770 780 790 800
CYFLKVFYPD VANAELPRML VDHKTKIIHV VDSYGSLSTG YHVLKTNTVE
810 820 830 840 850
QLIKFTRCNL ESSLKHYRVG GTEWEDTHGA KNIDDPQWCI KRLIKGVYRP
860 870 880 890 900
KQLKEDMLAN PFLPLYALLS PGVILAFYNS GSLEYLMNHY IRVDSNVAVL
910 920 930 940 950
LVVLKSLAKK VSTSQSVLAQ LQIIDRSLPE LVEARANINR PDDEAARACN
960 970 980 990 1000
RFMGMLLHMS EPNWELADGG YTILRDHSIS ILEKSYLQTL DEAWNELSWS
1010 1020 1030 1040 1050
ERCAIRYYSS KQAIFTQKDL PMRSEVDLGG RYSASVASSY EWSKQRVKSA
1060 1070 1080 1090 1100
YSRIGSRLRS GVSWTSSKVS NSVCRTINYL IPDVFRFINV LVCISLLVTI
1110 1120 1130 1140 1150
AAEANRIVTT QRRLKLDVEE TERRKIEWEL AFHHAILTQS AGQHPTIDEF
1160 1170 1180 1190 1200
STYIADKAPH LSEHIEPEEK VVVHQVKRQS EQELERIIAF VALVLMMFDA
1210 1220 1230 1240 1250
ERSDCVTKIL NKLKGLVATV EPTVYHQTLN DIEDDLSERN LFVDFELSSD
1260 1270 1280 1290 1300
GDMLQQLPTE KTFASWWNHQ LSRGFTIPHY RTEGKFMTFT RATATEVAGK
1310 1320 1330 1340 1350
IAHESDKDIL LMGAVGSGKS TGLPYHLSRK GNVLLLEPTR PLAENVHRQL
1360 1370 1380 1390 1400
SQAPFHQNTT LRMRGLTSFG SAPISVMTSG FALNYFANNR MRIEEFDFVI
1410 1420 1430 1440 1450
FDECHVHDAN AMAMRCLLHE CDYSGKIIKV SATPPGREVE FSTQYPVSIS
1460 1470 1480 1490 1500
TEDTLSFQDF VNAQGSGSNC DVISKGDNIL VYVASYNEVD ALSKLLTERD
1510 1520 1530 1540 1550
FKVTKVDGRT MKVGNIEITT SGTPSKKHFI VATNIIENGV TLDIDVVADF
1560 1570 1580 1590 1600
GTKVLPYLDT DSRMLSTTKT SINYGERIQR LGRVGRHKPG HALRIGHTEK
1610 1620 1630 1640 1650
GLSEVPSCIA TEAALKCFTY GLPVITNNVS TSILGNVTVK QARTMSVFEI
1660 1670 1680 1690 1700
TPFYTSQVVR YDGSMHPQVH ALLKRFKLRD SEIVLNKLAI PHRGVNAWLT
1710 1720 1730 1740 1750
ASEYARLGAN VEDRRDVRIP FMCRDIPEKL HLDMWDVIVK FKGDAGFGRL
1760 1770 1780 1790 1800
SSASASKVAY TLQTDVNSIQ RTVTIIDTLI AEERRKQEYF KTVTSNCVSS
1810 1820 1830 1840 1850
SNFSLQSITN AIKSRMMKDH TCENISVLEG AKSQLLEFRN LNADHSFATK
1860 1870 1880 1890 1900
TDGISQHFMS EYGALEAVHH QNTSDLSKFL KLKGKWNKTL ITRDVLVLCG
1910 1920 1930 1940 1950
VLGGGLWMVI QHLRSKISEP VTHEAKGKRQ RQKLKFRSIR DNKMGREVYG
1960 1970 1980 1990 2000
DDDTIEHFFG DAYTKKGKSK GRTRGLGHKN RKFINMYGFD PEDFSAVRFV
2010 2020 2030 2040 2050
DPLTGATLDD NPFTDIALVQ EHFGNIRMDL LGEDELDPNE VRMNKTIQAY
2060 2070 2080 2090 2100
YMNNKTGKAL KVDLTPHIPL KVCDLHATIA GFPERENELR QTGKAQPINI
2110 2120 2130 2140 2150
DEVPRANNEL VPVDHESNSM FRGLRDYNPI SNNICHLTNV SDGASNSLYG
2160 2170 2180 2190 2200
VGFGPLILTN RHLFERNNGE LIIKSRHGEF VIKNTTQLHL LPIPDRDLLL
2210 2220 2230 2240 2250
IRLPKDVPPF PQKLGFRQPE KGERICMVGS NFQTKSITSI VSETSTIMPV
2260 2270 2280 2290 2300
ENSQFWKHWI STKDGQCGSP MVSTKDGKIL GLHSLANFQN SINYFAAFPD
2310 2320 2330 2340 2350
DFAEKYLHTI EAHEWVKHWK YNTSAISWGA LNIQASQPSG LFKVSKLISD
2360 2370 2380 2390 2400
LDSTAVYAQT QQNRWMFEQL NGNLKAIAHC PSQLVTKHTV KGKCQMFDLY
2410 2420 2430 2440 2450
LKLHDEAREY FQPMLGQYQK SKLNREAYAK DLLKYATPIE AGNIDCDLFE
2460 2470 2480 2490 2500
KTVEIVISDL RGYGFETCNY VTDENDIFEA LNMKSAVGAL YKGKKKDYFA
2510 2520 2530 2540 2550
EFTPEMKEEI LKQSCERLFL GKMGVWNGSL KAELRPLEKV EANKTRTFTA
2560 2570 2580 2590 2600
APLDTLLGGK VCVDDFNNQF YDHNLRAPWS VGMTKFYCGW DRLLESLPDG
2610 2620 2630 2640 2650
WVYCDADGSQ FDSSLSPYLI NAILNIRLGF MEEWDVGEVM LRNLYTEIVY
2660 2670 2680 2690 2700
TPISTPDGTL VKKFKGNNSG QPSTVVDNTL MVILAVNYSL KKSGIPSELR
2710 2720 2730 2740 2750
DSIIRFFVNG DDLLLSVHPE YEYILDTMAD NFRELGLKYT FDSRTREKGD
2760 2770 2780 2790 2800
LWFMSHQGHK REGIWIPKLE PERIVSILEW DRSKEPCHRL EAICAAMIES
2810 2820 2830 2840 2850
WGYDKLTHEI RKFYAWMIEQ APFSSLAQEG KAPYIAETAL RKLYLDKEPA
2860 2870 2880 2890 2900
QEDLTHYLQA IFEDYEDGTE ACVYHQAGET LDAGLTDEQK QAEKEKKERE
2910 2920 2930 2940 2950
KAEKERERQR QLALKKGKNA AQEEGERDNE VNAGTSGTFS VPRLKSLTSK
2960 2970 2980 2990 3000
MRVPRYEQRV ALNLDHLILY TPEQTDLSNT RSTRKQFDTW FEGVMADYEL
3010 3020 3030 3040 3050
TEDKMQIILN GLMVWCIENG TSPNINGMWV MMDGDDQVEF PIKPLIDHAK
3060 3070 3080 3090 3100
PTFRQIMAHF SDVAEAYIEK RNQDRPYMPR YGLQRNLTDM SLARYAFDFY
3110 3120 3130 3140 3150
EMTSRTPIRA REAHIQMKAA ALRGANNNLF GLDGNVGTTV ENTERHTTED
3160
VNRNMHNGLG VKGL
Note: Produced by conventional translation.
Length:3,164
Mass (Da):357,737
Last modified:May 1, 1997 - v1
Checksum:i0DFC735CB3A5231F
GO
Isoform P3N-PIPO polyprotein (identifier: P0CK11-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CK11.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting in P3 ORF.
Length:1,043
Mass (Da):117,285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83184 Genomic RNA. Translation: BAA11836.1.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83184 Genomic RNA. Translation: BAA11836.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RNVX-ray2.00A663-820[»]
ProteinModelPortaliP89509.
SMRiP89509. Positions 2125-2338.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOLG_TUMVJ
AccessioniPrimary (citable) accession number: P89509
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: October 14, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.