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P89469

- DUT_HHV2H

UniProt

P89469 - DUT_HHV2H

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:UL50
    OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
    Taxonomic identifieri10315 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000001874: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000385167Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP89469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 2 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P89469-1 [UniParc]FASTAAdd to Basket

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    MSQWGPRAIL VQTDSTNRNA DGDWQAAVAI RGGGVVQLNM VNKRAVDFTP    50
    AECGDSEWAV GRVSLGLRMA MPRDFCAIIH APAVSGPGPH VMLGLVDSGY 100
    RGTVLAVVVA PNGTRGFAPG ALRVDVTFLD IRATPPTLTE PSSLHRFPQL 150
    APSPLAGLRE DPWLDGALAT AGGAVALPAR RRGGSLVYAG ELTQVTTEHG 200
    DCVHEAPAFL PKREEDAGFD ILIHRAVTVP ANGATVIQPS LRVLRAADGP 250
    EACYVLGRSS LNARGLLVMP TRWPSGHACA FVVCNLTGVP VTLQAGSKVA 300
    QLLVAGTHAL PWIPPDNIHE DGAFRAYPRG VPDATATPRD PPILVFTNEF 350
    DADAPPSKRG AGGFGSTGI 369
    Length:369
    Mass (Da):38,619
    Last modified:May 1, 1997 - v1
    Checksum:iF2A49CE503DCA16D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z86099 Genomic DNA. Translation: CAB06737.1.
    RefSeqiNP_044521.1. NC_001798.1.

    Genome annotation databases

    GeneIDi1487339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z86099 Genomic DNA. Translation: CAB06737.1 .
    RefSeqi NP_044521.1. NC_001798.1.

    3D structure databases

    ProteinModelPortali P89469.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487339.

    Family and domain databases

    Gene3Di 2.70.40.10. 2 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of herpes simplex virus type 2."
      Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
      J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_HHV2H
    AccessioniPrimary (citable) accession number: P89469
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3