Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P89469

- DUT_HHV2H

UniProt

P89469 - DUT_HHV2H

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:UL50
OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Taxonomic identifieri10315 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001874: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000385167Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP89469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 2 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P89469 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQWGPRAIL VQTDSTNRNA DGDWQAAVAI RGGGVVQLNM VNKRAVDFTP
60 70 80 90 100
AECGDSEWAV GRVSLGLRMA MPRDFCAIIH APAVSGPGPH VMLGLVDSGY
110 120 130 140 150
RGTVLAVVVA PNGTRGFAPG ALRVDVTFLD IRATPPTLTE PSSLHRFPQL
160 170 180 190 200
APSPLAGLRE DPWLDGALAT AGGAVALPAR RRGGSLVYAG ELTQVTTEHG
210 220 230 240 250
DCVHEAPAFL PKREEDAGFD ILIHRAVTVP ANGATVIQPS LRVLRAADGP
260 270 280 290 300
EACYVLGRSS LNARGLLVMP TRWPSGHACA FVVCNLTGVP VTLQAGSKVA
310 320 330 340 350
QLLVAGTHAL PWIPPDNIHE DGAFRAYPRG VPDATATPRD PPILVFTNEF
360
DADAPPSKRG AGGFGSTGI
Length:369
Mass (Da):38,619
Last modified:May 1, 1997 - v1
Checksum:iF2A49CE503DCA16D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06737.1.
RefSeqiNP_044521.1. NC_001798.1.

Genome annotation databases

GeneIDi1487339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06737.1 .
RefSeqi NP_044521.1. NC_001798.1.

3D structure databases

ProteinModelPortali P89469.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487339.

Family and domain databases

Gene3Di 2.70.40.10. 2 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of herpes simplex virus type 2."
    Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
    J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV2H
AccessioniPrimary (citable) accession number: P89469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 1, 1997
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3