Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P89469 (DUT_HHV2H) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
ORF Names:UL50
OrganismHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) [Reference proteome]
Taxonomic identifier10315 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000385167

Sequences

Sequence LengthMass (Da)Tools
P89469 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: F2A49CE503DCA16D

FASTA36938,619
        10         20         30         40         50         60 
MSQWGPRAIL VQTDSTNRNA DGDWQAAVAI RGGGVVQLNM VNKRAVDFTP AECGDSEWAV 

        70         80         90        100        110        120 
GRVSLGLRMA MPRDFCAIIH APAVSGPGPH VMLGLVDSGY RGTVLAVVVA PNGTRGFAPG 

       130        140        150        160        170        180 
ALRVDVTFLD IRATPPTLTE PSSLHRFPQL APSPLAGLRE DPWLDGALAT AGGAVALPAR 

       190        200        210        220        230        240 
RRGGSLVYAG ELTQVTTEHG DCVHEAPAFL PKREEDAGFD ILIHRAVTVP ANGATVIQPS 

       250        260        270        280        290        300 
LRVLRAADGP EACYVLGRSS LNARGLLVMP TRWPSGHACA FVVCNLTGVP VTLQAGSKVA 

       310        320        330        340        350        360 
QLLVAGTHAL PWIPPDNIHE DGAFRAYPRG VPDATATPRD PPILVFTNEF DADAPPSKRG 


AGGFGSTGI 

« Hide

References

[1]"The genome sequence of herpes simplex virus type 2."
Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z86099 Genomic DNA. Translation: CAB06737.1.
RefSeqNP_044521.1. NC_001798.1.

3D structure databases

ProteinModelPortalP89469.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487339.

Phylogenomic databases

ProtClustDBPHA3130.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_HHV2H
AccessionPrimary (citable) accession number: P89469
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families