P89469 (DUT_HHV2H) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

ORF Names:

UL50

Organism

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) [Reference proteome]

Taxonomic identifier

10315 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 2

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000385167

Sequences

	Sequence		Length	Mass (Da)
	P89469 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: F2A49CE503DCA16D	FASTA	369	38,619
	10 20 30 40 50 60 MSQWGPRAIL VQTDSTNRNA DGDWQAAVAI RGGGVVQLNM VNKRAVDFTP AECGDSEWAV 70 80 90 100 110 120 GRVSLGLRMA MPRDFCAIIH APAVSGPGPH VMLGLVDSGY RGTVLAVVVA PNGTRGFAPG 130 140 150 160 170 180 ALRVDVTFLD IRATPPTLTE PSSLHRFPQL APSPLAGLRE DPWLDGALAT AGGAVALPAR 190 200 210 220 230 240 RRGGSLVYAG ELTQVTTEHG DCVHEAPAFL PKREEDAGFD ILIHRAVTVP ANGATVIQPS 250 260 270 280 290 300 LRVLRAADGP EACYVLGRSS LNARGLLVMP TRWPSGHACA FVVCNLTGVP VTLQAGSKVA 310 320 330 340 350 360 QLLVAGTHAL PWIPPDNIHE DGAFRAYPRG VPDATATPRD PPILVFTNEF DADAPPSKRG AGGFGSTGI

References

[1]	"The genome sequence of herpes simplex virus type 2." Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J. J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z86099 Genomic DNA. Translation: CAB06737.1.
RefSeq	NP_044521.1. NC_001798.1.
3D structure databases
ProteinModelPortal	P89469.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487339.
Phylogenomic databases
ProtClustDB	PHA3130.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_HHV2H

Accession

Primary (citable) accession number: P89469

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program