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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL50
OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Taxonomic identifieri10315 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000001874 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851671 – 369Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST369

Proteomic databases

PRIDEiP89469

Structurei

3D structure databases

ProteinModelPortaliP89469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 260Substrate bindingUniRule annotation3
Regioni364 – 365Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 1 hit
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits

Sequencei

Sequence statusi: Complete.

P89469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQWGPRAIL VQTDSTNRNA DGDWQAAVAI RGGGVVQLNM VNKRAVDFTP
60 70 80 90 100
AECGDSEWAV GRVSLGLRMA MPRDFCAIIH APAVSGPGPH VMLGLVDSGY
110 120 130 140 150
RGTVLAVVVA PNGTRGFAPG ALRVDVTFLD IRATPPTLTE PSSLHRFPQL
160 170 180 190 200
APSPLAGLRE DPWLDGALAT AGGAVALPAR RRGGSLVYAG ELTQVTTEHG
210 220 230 240 250
DCVHEAPAFL PKREEDAGFD ILIHRAVTVP ANGATVIQPS LRVLRAADGP
260 270 280 290 300
EACYVLGRSS LNARGLLVMP TRWPSGHACA FVVCNLTGVP VTLQAGSKVA
310 320 330 340 350
QLLVAGTHAL PWIPPDNIHE DGAFRAYPRG VPDATATPRD PPILVFTNEF
360
DADAPPSKRG AGGFGSTGI
Length:369
Mass (Da):38,619
Last modified:May 1, 1997 - v1
Checksum:iF2A49CE503DCA16D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z86099 Genomic DNA Translation: CAB06737.1
RefSeqiYP_009137203.1, NC_001798.2

Genome annotation databases

GeneIDi1487339
KEGGivg:1487339

Similar proteinsi

Entry informationi

Entry nameiDUT_HHV2H
AccessioniPrimary (citable) accession number: P89469
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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