P89442 (MCP_HHV2H) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein
Short name=MCP

Alternative name(s):
Capsid protein VP5

Gene names

Name:

UL19

Organism

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) [Reference proteome]

Taxonomic identifier

10315 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 2

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	1374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.
Subunit structure	Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.
Subcellular location	Virion. Host nucleus.
Sequence similarities	Belongs to the herpesviridae major capsid protein family.

Ontologies

Keywords
Cellular component	Host nucleus Virion
Molecular function	Capsid protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1374	1374	Major capsid protein		PRO_0000406185

Sequences

	Sequence		Length	Mass (Da)
	P89442 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: ECEE85351E4C1939	FASTA	1,374	149,238
	10 20 30 40 50 60 MAAPARDPPG YRYAAAILPT GSILSTIEVA SHRRLFDFFA AVRSDENSLY DVEFDALLGS 70 80 90 100 110 120 YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH QPLIARDGPH PVEQPVHNYM 130 140 150 160 170 180 TKVIDRRALN AAFSLATEAI ALLTGEALDG TGISLHRQLR AIQQLARNVQ AVLGAFERGT 190 200 210 220 230 240 ADQMLHVLLE KAPPLALLLP MQRYLDNGRL ATRVARATLV AELKRSFCDT SFFLGKAGHR 250 260 270 280 290 300 REAIEAWLVD LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAAIKQRLLQ SFLKVEDTEA 310 320 330 340 350 360 DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLDMQ EEQLEANRET LDELESAPQT 370 380 390 400 410 420 TRVRADLVAI GDRLVFLEAL ERRIYAATNV PYPLVGAMDL TFVLPLGLFN PAMERFAAHA 430 440 450 460 470 480 GDLVPAPGHP EPRAFPPRQL FFWGKDHQVL RLSMENAVGT VCHPSLMNID AAVGGVNHDP 490 500 510 520 530 540 VEAANPYGAY VAAPAGPGAD MQQRFLNAWR QRLAHGRVRW VAECQMTAEQ FMQPDNANLA 550 560 570 580 590 600 LELHPAFDFF AGVADVELPG GEVPPAGPGA IQATWRVVNG NLPLALCPVA FRDARGLELG 610 620 630 640 650 660 VGRHAMAPAT IAAVRGAFED RSYPAVFYLL QAAIHGNEHV FCALARLVTQ CITSYWNNTR 670 680 690 700 710 720 CAAFVNDYSL VSYIVTYLGG DLPEECMAVY RDLVAHVEAL AQLVDDFTLP GPELGGQAQA 730 740 750 760 770 780 ELNHLMRDPA LLPPLVWDCD GLMRHAALDR HRDCRIDAGG HEPVYAAACN VATADFNRND 790 800 810 820 830 840 GRLLHNTQAR AADAADDRPH RPADWTVHHK IYYYVLVPAF SRGRCCTAGV RFDRVYATLQ 850 860 870 880 890 900 NMVVPEIAPG EECPSDPVTD PAHPLHPANL VANTVKRMFH NGRVVVDGPA MLTLQVLAHN 910 920 930 940 950 960 MAERTTALLC SAAPDAGANT ASTANMRIFD GALHAGVLLM APQHLDHTIQ NGEYFYVLPV 970 980 990 1000 1010 1020 HALFAGADHV ANAPNFPPAL RDLARDVPLV PPALGANYFS SIRQPVVQHA RESAAGENAL 1030 1040 1050 1060 1070 1080 TYALMAGYFK MSPVALYHQL KTGLHPGFGF TVVRQDRFVT ENVLFSERAS EAYFLGQLQV 1090 1100 1110 1120 1130 1140 ARHETGGGVN FTLTQPRGNV DLGVGYTAVA ATGTVRNPVT DMGNLPQNFY LGRGAPPLLD 1150 1160 1170 1180 1190 1200 NAAAVYLRNA VVAGNRLGPA QPLPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVATDINYFR 1210 1220 1230 1240 1250 1260 RPCNPRGRAA GGVYAGDKEG DVIALMYDHG QSDPARPFAA TANPWASQRF SYGDLLYNGA 1270 1280 1290 1300 1310 1320 YHLNGASPVL SPCFKFFTAA DITAKHRCLE RLIVETGSAV STATAASDVQ FKRPPGCREL 1330 1340 1350 1360 1370 VEDPCGLFQE AYPITCASDP ALLRSARDGE AHARETHFTQ YLIYDASPLK GLSL

References

[1]

"Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2." McGeoch D.J., Cunningham C., McIntyre G., Dolan A. J. Gen. Virol. 72:3057-3075(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z86099 Genomic DNA. Translation: CAB06743.1.
RefSeq	NP_044488.1. NC_001798.1.
3D structure databases
ProteinModelPortal	P89442.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487302.
Phylogenomic databases
ProtClustDB	CLSP2509619.
Family and domain databases
InterPro	IPR000912. Herpes_MCP. IPR023233. Herpes_MCP_upper. [Graphical view]
Pfam	PF03122. Herpes_MCP. 1 hit. [Graphical view]
PRINTS	PR00235. HSVCAPSIDMCP.
SUPFAM	SSF103417. Herpes_MCP_upper. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCP_HHV2H

Accession

Primary (citable) accession number: P89442

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	May 1, 1997
Last modified:	May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program