Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P89442

- MCP_HHV2H

UniProt

P89442 - MCP_HHV2H

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Major capsid protein

Gene

UL19

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Short name:
MCP
Alternative name(s):
Capsid protein VP5
Gene namesi
Name:UL19
OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Taxonomic identifieri10315 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001874: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Major capsid proteinPRO_0000406185Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.

Structurei

3D structure databases

ProteinModelPortaliP89442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P89442 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPARDPPG YRYAAAILPT GSILSTIEVA SHRRLFDFFA AVRSDENSLY
60 70 80 90 100
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH
110 120 130 140 150
QPLIARDGPH PVEQPVHNYM TKVIDRRALN AAFSLATEAI ALLTGEALDG
160 170 180 190 200
TGISLHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP
210 220 230 240 250
MQRYLDNGRL ATRVARATLV AELKRSFCDT SFFLGKAGHR REAIEAWLVD
260 270 280 290 300
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAAIKQRLLQ SFLKVEDTEA
310 320 330 340 350
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLDMQ EEQLEANRET
360 370 380 390 400
LDELESAPQT TRVRADLVAI GDRLVFLEAL ERRIYAATNV PYPLVGAMDL
410 420 430 440 450
TFVLPLGLFN PAMERFAAHA GDLVPAPGHP EPRAFPPRQL FFWGKDHQVL
460 470 480 490 500
RLSMENAVGT VCHPSLMNID AAVGGVNHDP VEAANPYGAY VAAPAGPGAD
510 520 530 540 550
MQQRFLNAWR QRLAHGRVRW VAECQMTAEQ FMQPDNANLA LELHPAFDFF
560 570 580 590 600
AGVADVELPG GEVPPAGPGA IQATWRVVNG NLPLALCPVA FRDARGLELG
610 620 630 640 650
VGRHAMAPAT IAAVRGAFED RSYPAVFYLL QAAIHGNEHV FCALARLVTQ
660 670 680 690 700
CITSYWNNTR CAAFVNDYSL VSYIVTYLGG DLPEECMAVY RDLVAHVEAL
710 720 730 740 750
AQLVDDFTLP GPELGGQAQA ELNHLMRDPA LLPPLVWDCD GLMRHAALDR
760 770 780 790 800
HRDCRIDAGG HEPVYAAACN VATADFNRND GRLLHNTQAR AADAADDRPH
810 820 830 840 850
RPADWTVHHK IYYYVLVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG
860 870 880 890 900
EECPSDPVTD PAHPLHPANL VANTVKRMFH NGRVVVDGPA MLTLQVLAHN
910 920 930 940 950
MAERTTALLC SAAPDAGANT ASTANMRIFD GALHAGVLLM APQHLDHTIQ
960 970 980 990 1000
NGEYFYVLPV HALFAGADHV ANAPNFPPAL RDLARDVPLV PPALGANYFS
1010 1020 1030 1040 1050
SIRQPVVQHA RESAAGENAL TYALMAGYFK MSPVALYHQL KTGLHPGFGF
1060 1070 1080 1090 1100
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRGNV
1110 1120 1130 1140 1150
DLGVGYTAVA ATGTVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA
1160 1170 1180 1190 1200
VVAGNRLGPA QPLPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVATDINYFR
1210 1220 1230 1240 1250
RPCNPRGRAA GGVYAGDKEG DVIALMYDHG QSDPARPFAA TANPWASQRF
1260 1270 1280 1290 1300
SYGDLLYNGA YHLNGASPVL SPCFKFFTAA DITAKHRCLE RLIVETGSAV
1310 1320 1330 1340 1350
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPITCASDP ALLRSARDGE
1360 1370
AHARETHFTQ YLIYDASPLK GLSL
Length:1,374
Mass (Da):149,238
Last modified:May 1, 1997 - v1
Checksum:iECEE85351E4C1939
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06743.1.
RefSeqiNP_044488.1. NC_001798.1.

Genome annotation databases

GeneIDi1487302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06743.1 .
RefSeqi NP_044488.1. NC_001798.1.

3D structure databases

ProteinModelPortali P89442.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487302.

Family and domain databases

InterProi IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view ]
Pfami PF03122. Herpes_MCP. 1 hit.
[Graphical view ]
PRINTSi PR00235. HSVCAPSIDMCP.
SUPFAMi SSF103417. SSF103417. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2."
    McGeoch D.J., Cunningham C., McIntyre G., Dolan A.
    J. Gen. Virol. 72:3057-3075(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMCP_HHV2H
AccessioniPrimary (citable) accession number: P89442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3