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P89442

- MCP_HHV2H

UniProt

P89442 - MCP_HHV2H

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Protein
Major capsid protein
Gene
UL19
Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Short name:
MCP
Alternative name(s):
Capsid protein VP5
Gene namesi
Name:UL19
OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Taxonomic identifieri10315 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001874: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Major capsid protein
PRO_0000406185Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.

Structurei

3D structure databases

ProteinModelPortaliP89442.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P89442-1 [UniParc]FASTAAdd to Basket

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MAAPARDPPG YRYAAAILPT GSILSTIEVA SHRRLFDFFA AVRSDENSLY     50
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH 100
QPLIARDGPH PVEQPVHNYM TKVIDRRALN AAFSLATEAI ALLTGEALDG 150
TGISLHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP 200
MQRYLDNGRL ATRVARATLV AELKRSFCDT SFFLGKAGHR REAIEAWLVD 250
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAAIKQRLLQ SFLKVEDTEA 300
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLDMQ EEQLEANRET 350
LDELESAPQT TRVRADLVAI GDRLVFLEAL ERRIYAATNV PYPLVGAMDL 400
TFVLPLGLFN PAMERFAAHA GDLVPAPGHP EPRAFPPRQL FFWGKDHQVL 450
RLSMENAVGT VCHPSLMNID AAVGGVNHDP VEAANPYGAY VAAPAGPGAD 500
MQQRFLNAWR QRLAHGRVRW VAECQMTAEQ FMQPDNANLA LELHPAFDFF 550
AGVADVELPG GEVPPAGPGA IQATWRVVNG NLPLALCPVA FRDARGLELG 600
VGRHAMAPAT IAAVRGAFED RSYPAVFYLL QAAIHGNEHV FCALARLVTQ 650
CITSYWNNTR CAAFVNDYSL VSYIVTYLGG DLPEECMAVY RDLVAHVEAL 700
AQLVDDFTLP GPELGGQAQA ELNHLMRDPA LLPPLVWDCD GLMRHAALDR 750
HRDCRIDAGG HEPVYAAACN VATADFNRND GRLLHNTQAR AADAADDRPH 800
RPADWTVHHK IYYYVLVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG 850
EECPSDPVTD PAHPLHPANL VANTVKRMFH NGRVVVDGPA MLTLQVLAHN 900
MAERTTALLC SAAPDAGANT ASTANMRIFD GALHAGVLLM APQHLDHTIQ 950
NGEYFYVLPV HALFAGADHV ANAPNFPPAL RDLARDVPLV PPALGANYFS 1000
SIRQPVVQHA RESAAGENAL TYALMAGYFK MSPVALYHQL KTGLHPGFGF 1050
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRGNV 1100
DLGVGYTAVA ATGTVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA 1150
VVAGNRLGPA QPLPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVATDINYFR 1200
RPCNPRGRAA GGVYAGDKEG DVIALMYDHG QSDPARPFAA TANPWASQRF 1250
SYGDLLYNGA YHLNGASPVL SPCFKFFTAA DITAKHRCLE RLIVETGSAV 1300
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPITCASDP ALLRSARDGE 1350
AHARETHFTQ YLIYDASPLK GLSL 1374
Length:1,374
Mass (Da):149,238
Last modified:May 1, 1997 - v1
Checksum:iECEE85351E4C1939
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06743.1.
RefSeqiNP_044488.1. NC_001798.1.

Genome annotation databases

GeneIDi1487302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z86099 Genomic DNA. Translation: CAB06743.1 .
RefSeqi NP_044488.1. NC_001798.1.

3D structure databases

ProteinModelPortali P89442.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487302.

Family and domain databases

InterProi IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view ]
Pfami PF03122. Herpes_MCP. 1 hit.
[Graphical view ]
PRINTSi PR00235. HSVCAPSIDMCP.
SUPFAMi SSF103417. SSF103417. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2."
    McGeoch D.J., Cunningham C., McIntyre G., Dolan A.
    J. Gen. Virol. 72:3057-3075(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMCP_HHV2H
AccessioniPrimary (citable) accession number: P89442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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