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P89442 (MCP_HHV2H) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major capsid protein

Short name=MCP
Alternative name(s):
Capsid protein VP5
Gene names
Name:UL19
OrganismHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) [Reference proteome]
Taxonomic identifier10315 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.

Subunit structure

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.

Subcellular location

Virion. Host nucleus.

Sequence similarities

Belongs to the herpesviridae major capsid protein family.

Ontologies

Keywords
   Cellular componentCapsid protein
Host nucleus
Virion
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13741374Major capsid protein
PRO_0000406185

Sequences

Sequence LengthMass (Da)Tools
P89442 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: ECEE85351E4C1939

FASTA1,374149,238
        10         20         30         40         50         60 
MAAPARDPPG YRYAAAILPT GSILSTIEVA SHRRLFDFFA AVRSDENSLY DVEFDALLGS 

        70         80         90        100        110        120 
YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH QPLIARDGPH PVEQPVHNYM 

       130        140        150        160        170        180 
TKVIDRRALN AAFSLATEAI ALLTGEALDG TGISLHRQLR AIQQLARNVQ AVLGAFERGT 

       190        200        210        220        230        240 
ADQMLHVLLE KAPPLALLLP MQRYLDNGRL ATRVARATLV AELKRSFCDT SFFLGKAGHR 

       250        260        270        280        290        300 
REAIEAWLVD LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAAIKQRLLQ SFLKVEDTEA 

       310        320        330        340        350        360 
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLDMQ EEQLEANRET LDELESAPQT 

       370        380        390        400        410        420 
TRVRADLVAI GDRLVFLEAL ERRIYAATNV PYPLVGAMDL TFVLPLGLFN PAMERFAAHA 

       430        440        450        460        470        480 
GDLVPAPGHP EPRAFPPRQL FFWGKDHQVL RLSMENAVGT VCHPSLMNID AAVGGVNHDP 

       490        500        510        520        530        540 
VEAANPYGAY VAAPAGPGAD MQQRFLNAWR QRLAHGRVRW VAECQMTAEQ FMQPDNANLA 

       550        560        570        580        590        600 
LELHPAFDFF AGVADVELPG GEVPPAGPGA IQATWRVVNG NLPLALCPVA FRDARGLELG 

       610        620        630        640        650        660 
VGRHAMAPAT IAAVRGAFED RSYPAVFYLL QAAIHGNEHV FCALARLVTQ CITSYWNNTR 

       670        680        690        700        710        720 
CAAFVNDYSL VSYIVTYLGG DLPEECMAVY RDLVAHVEAL AQLVDDFTLP GPELGGQAQA 

       730        740        750        760        770        780 
ELNHLMRDPA LLPPLVWDCD GLMRHAALDR HRDCRIDAGG HEPVYAAACN VATADFNRND 

       790        800        810        820        830        840 
GRLLHNTQAR AADAADDRPH RPADWTVHHK IYYYVLVPAF SRGRCCTAGV RFDRVYATLQ 

       850        860        870        880        890        900 
NMVVPEIAPG EECPSDPVTD PAHPLHPANL VANTVKRMFH NGRVVVDGPA MLTLQVLAHN 

       910        920        930        940        950        960 
MAERTTALLC SAAPDAGANT ASTANMRIFD GALHAGVLLM APQHLDHTIQ NGEYFYVLPV 

       970        980        990       1000       1010       1020 
HALFAGADHV ANAPNFPPAL RDLARDVPLV PPALGANYFS SIRQPVVQHA RESAAGENAL 

      1030       1040       1050       1060       1070       1080 
TYALMAGYFK MSPVALYHQL KTGLHPGFGF TVVRQDRFVT ENVLFSERAS EAYFLGQLQV 

      1090       1100       1110       1120       1130       1140 
ARHETGGGVN FTLTQPRGNV DLGVGYTAVA ATGTVRNPVT DMGNLPQNFY LGRGAPPLLD 

      1150       1160       1170       1180       1190       1200 
NAAAVYLRNA VVAGNRLGPA QPLPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVATDINYFR 

      1210       1220       1230       1240       1250       1260 
RPCNPRGRAA GGVYAGDKEG DVIALMYDHG QSDPARPFAA TANPWASQRF SYGDLLYNGA 

      1270       1280       1290       1300       1310       1320 
YHLNGASPVL SPCFKFFTAA DITAKHRCLE RLIVETGSAV STATAASDVQ FKRPPGCREL 

      1330       1340       1350       1360       1370 
VEDPCGLFQE AYPITCASDP ALLRSARDGE AHARETHFTQ YLIYDASPLK GLSL 

« Hide

References

[1]"Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2."
McGeoch D.J., Cunningham C., McIntyre G., Dolan A.
J. Gen. Virol. 72:3057-3075(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z86099 Genomic DNA. Translation: CAB06743.1.
RefSeqNP_044488.1. NC_001798.1.

3D structure databases

ProteinModelPortalP89442.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487302.

Family and domain databases

InterProIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSPR00235. HSVCAPSIDMCP.
SUPFAMSSF103417. SSF103417. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCP_HHV2H
AccessionPrimary (citable) accession number: P89442
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families