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P89442

- MCP_HHV2H

UniProt

P89442 - MCP_HHV2H

Protein

Major capsid protein

Gene

UL19

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major capsid protein
    Short name:
    MCP
    Alternative name(s):
    Capsid protein VP5
    Gene namesi
    Name:UL19
    OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
    Taxonomic identifieri10315 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000001874: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13741374Major capsid proteinPRO_0000406185Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.

    Structurei

    3D structure databases

    ProteinModelPortaliP89442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000912. Herpes_MCP.
    IPR023233. Herpes_MCP_upper.
    [Graphical view]
    PfamiPF03122. Herpes_MCP. 1 hit.
    [Graphical view]
    PRINTSiPR00235. HSVCAPSIDMCP.
    SUPFAMiSSF103417. SSF103417. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P89442-1 [UniParc]FASTAAdd to Basket

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    MAAPARDPPG YRYAAAILPT GSILSTIEVA SHRRLFDFFA AVRSDENSLY     50
    DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH 100
    QPLIARDGPH PVEQPVHNYM TKVIDRRALN AAFSLATEAI ALLTGEALDG 150
    TGISLHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP 200
    MQRYLDNGRL ATRVARATLV AELKRSFCDT SFFLGKAGHR REAIEAWLVD 250
    LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAAIKQRLLQ SFLKVEDTEA 300
    DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLDMQ EEQLEANRET 350
    LDELESAPQT TRVRADLVAI GDRLVFLEAL ERRIYAATNV PYPLVGAMDL 400
    TFVLPLGLFN PAMERFAAHA GDLVPAPGHP EPRAFPPRQL FFWGKDHQVL 450
    RLSMENAVGT VCHPSLMNID AAVGGVNHDP VEAANPYGAY VAAPAGPGAD 500
    MQQRFLNAWR QRLAHGRVRW VAECQMTAEQ FMQPDNANLA LELHPAFDFF 550
    AGVADVELPG GEVPPAGPGA IQATWRVVNG NLPLALCPVA FRDARGLELG 600
    VGRHAMAPAT IAAVRGAFED RSYPAVFYLL QAAIHGNEHV FCALARLVTQ 650
    CITSYWNNTR CAAFVNDYSL VSYIVTYLGG DLPEECMAVY RDLVAHVEAL 700
    AQLVDDFTLP GPELGGQAQA ELNHLMRDPA LLPPLVWDCD GLMRHAALDR 750
    HRDCRIDAGG HEPVYAAACN VATADFNRND GRLLHNTQAR AADAADDRPH 800
    RPADWTVHHK IYYYVLVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG 850
    EECPSDPVTD PAHPLHPANL VANTVKRMFH NGRVVVDGPA MLTLQVLAHN 900
    MAERTTALLC SAAPDAGANT ASTANMRIFD GALHAGVLLM APQHLDHTIQ 950
    NGEYFYVLPV HALFAGADHV ANAPNFPPAL RDLARDVPLV PPALGANYFS 1000
    SIRQPVVQHA RESAAGENAL TYALMAGYFK MSPVALYHQL KTGLHPGFGF 1050
    TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRGNV 1100
    DLGVGYTAVA ATGTVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA 1150
    VVAGNRLGPA QPLPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVATDINYFR 1200
    RPCNPRGRAA GGVYAGDKEG DVIALMYDHG QSDPARPFAA TANPWASQRF 1250
    SYGDLLYNGA YHLNGASPVL SPCFKFFTAA DITAKHRCLE RLIVETGSAV 1300
    STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPITCASDP ALLRSARDGE 1350
    AHARETHFTQ YLIYDASPLK GLSL 1374
    Length:1,374
    Mass (Da):149,238
    Last modified:May 1, 1997 - v1
    Checksum:iECEE85351E4C1939
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z86099 Genomic DNA. Translation: CAB06743.1.
    RefSeqiNP_044488.1. NC_001798.1.

    Genome annotation databases

    GeneIDi1487302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z86099 Genomic DNA. Translation: CAB06743.1 .
    RefSeqi NP_044488.1. NC_001798.1.

    3D structure databases

    ProteinModelPortali P89442.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487302.

    Family and domain databases

    InterProi IPR000912. Herpes_MCP.
    IPR023233. Herpes_MCP_upper.
    [Graphical view ]
    Pfami PF03122. Herpes_MCP. 1 hit.
    [Graphical view ]
    PRINTSi PR00235. HSVCAPSIDMCP.
    SUPFAMi SSF103417. SSF103417. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2."
      McGeoch D.J., Cunningham C., McIntyre G., Dolan A.
      J. Gen. Virol. 72:3057-3075(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMCP_HHV2H
    AccessioniPrimary (citable) accession number: P89442
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3