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P89034

- RDRP_PMVK

UniProt

P89034 - RDRP_PMVK

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Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Panicum mosaic virus (strain United States/Kansas 109S) (PMV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.1 Publication

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p112
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiPanicum mosaic virus (strain United States/Kansas 109S) (PMV)
Taxonomic identifieri652599 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaePanicovirus
Virus hostiMuhlenbergia [TaxID: 58090]
Panicum virgatum (Switchgrass) [TaxID: 38727]
ProteomesiUP000001665: Genome

Subcellular locationi

Host membrane 1 Publication

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 992992RNA-directed RNA polymerase
PRO_0000399486Add
BLAST
Chaini1 – 425425Protein p48
PRO_0000399487Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP89034.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini656 – 772117RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P89034-1 [UniParc]FASTAAdd to Basket

« Hide

MESLIQHILS ATSSLSMPSV DSDKLQLLLT RFPQATLSWL SGIDGLSVHQ    50
FKVVATHVIK ESYSHLSPSV AVLLAKPSDY YKLVVHGLTQ KQWNEFDDKV 100
TDAPRTAISW LYNQILVVGQ PWMKSLNEGL KEYLPGWLHT CLRMLANLWF 150
GAERVLHGIS HAVSDITTYQ PWMSCRRCVA HSPKESLLGE ATTTSNPRES 200
SWFSWLLCGG VVAATVYGFY KWVTITETID RQDLAKQRPT HMQKCYEEVK 250
ARLEEESKGF IHDRMEDELT KIVLEPAEID NDGKVLKSEV AQYLVKNHGR 300
FVRSLVTMAK NEFAGVPKPT EANQLAVWRY LYRVCDKKGV NPSDTQKSIS 350
AALPFVFLPS AYDQDQAITM NCDDTKKVLE RYADTFRHTT PLQKLVTNPL 400
VGANWTAWAR SIFISDPETG LRFAKXGCIE KWQGVQCKRT RVRHPRLRCH 450
FKDRDPKVRS IYRIAGLGDQ YEFGLHNNSA ANLERGLAER VYMVKNYKTD 500
FVASLDPAFC PAPEPVRGIF KRLDKYKKEI VRRVGRKSPI TDEMFLSYYD 550
GPQLTTYSKA VISLSERPVA VQDSYLKTFI KAEKLNLTLK TDPCPRVIQP 600
RHPRYNVELG KYLKHIEHPI YKAIDRIWGG KTIFKGMNVE AMGAEIHKKM 650
CKYSNPCAIG FDASRFDQHV SVEALRFEHS IYKSIHGYPE LLSLLLKWQI 700
HNQGTAHTND GFFKYLVDGK RMSGDMNTSL GNCILASLIV KDLVDSLGVD 750
AQLVNNGDDN VLICSVDDEE VVVKALYDHW MKYGFEVVAE QPVYITEQIE 800
FCQMKPVFDG TQYVLVRNPT VTMSKDACSI TPFYTANSAR KWCRAVGEAG 850
LSLTGGMPIK QAYYQCMIRN GINKGNIHKS KEFRYGLSYV LHHGKSDRKA 900
RPISAATRYS FYLAFGYTPD EQTALEGYYD SLELEWTESR LGIPARTPEC 950
LLLRLLPKIP LQPKSPTKPV QRTASKPDLP DSQWQQALAA PL 992
Length:992
Mass (Da):112,683
Last modified:May 1, 1997 - v1
Checksum:iC54AB9AFA91301A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55002 Genomic RNA. Translation: AAC97551.1.
U55002 Genomic RNA. Translation: AAC97552.1.
RefSeqiNP_068342.1. NC_002598.1.
NP_068343.1. NC_002598.1.

Genome annotation databases

GeneIDi912246.
912248.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55002 Genomic RNA. Translation: AAC97551.1 .
U55002 Genomic RNA. Translation: AAC97552.1 .
RefSeqi NP_068342.1. NC_002598.1.
NP_068343.1. NC_002598.1.

3D structure databases

ProteinModelPortali P89034.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 912246.
912248.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and infectivity of a full-length cDNA clone of panicum mosaic virus."
    Turina M., Maruoka M., Monis J., Jackson A.O., Scholthof K.B.
    Virology 241:141-155(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Panicovirus accumulation is governed by two membrane-associated proteins with a newly identified conserved motif that contributes to pathogenicity."
    Batten J.S., Turina M., Scholthof K.B.
    Virol. J. 3:12-12(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRDRP_PMVK
AccessioniPrimary (citable) accession number: P89034
Secondary accession number(s): P90334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 426.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi