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P89034

- RDRP_PMVK

UniProt

P89034 - RDRP_PMVK

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Panicum mosaic virus (strain United States/Kansas 109S) (PMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.1 Publication

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p112
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiPanicum mosaic virus (strain United States/Kansas 109S) (PMV)
    Taxonomic identifieri652599 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaePanicovirus
    Virus hostiMuhlenbergia [TaxID: 58090]
    Panicum virgatum (Switchgrass) [TaxID: 38727]
    ProteomesiUP000001665: Genome

    Subcellular locationi

    Host membrane 1 Publication

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 992992RNA-directed RNA polymerasePRO_0000399486Add
    BLAST
    Chaini1 – 425425Protein p48PRO_0000399487Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP89034.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini656 – 772117RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P89034-1 [UniParc]FASTAAdd to Basket

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    MESLIQHILS ATSSLSMPSV DSDKLQLLLT RFPQATLSWL SGIDGLSVHQ    50
    FKVVATHVIK ESYSHLSPSV AVLLAKPSDY YKLVVHGLTQ KQWNEFDDKV 100
    TDAPRTAISW LYNQILVVGQ PWMKSLNEGL KEYLPGWLHT CLRMLANLWF 150
    GAERVLHGIS HAVSDITTYQ PWMSCRRCVA HSPKESLLGE ATTTSNPRES 200
    SWFSWLLCGG VVAATVYGFY KWVTITETID RQDLAKQRPT HMQKCYEEVK 250
    ARLEEESKGF IHDRMEDELT KIVLEPAEID NDGKVLKSEV AQYLVKNHGR 300
    FVRSLVTMAK NEFAGVPKPT EANQLAVWRY LYRVCDKKGV NPSDTQKSIS 350
    AALPFVFLPS AYDQDQAITM NCDDTKKVLE RYADTFRHTT PLQKLVTNPL 400
    VGANWTAWAR SIFISDPETG LRFAKXGCIE KWQGVQCKRT RVRHPRLRCH 450
    FKDRDPKVRS IYRIAGLGDQ YEFGLHNNSA ANLERGLAER VYMVKNYKTD 500
    FVASLDPAFC PAPEPVRGIF KRLDKYKKEI VRRVGRKSPI TDEMFLSYYD 550
    GPQLTTYSKA VISLSERPVA VQDSYLKTFI KAEKLNLTLK TDPCPRVIQP 600
    RHPRYNVELG KYLKHIEHPI YKAIDRIWGG KTIFKGMNVE AMGAEIHKKM 650
    CKYSNPCAIG FDASRFDQHV SVEALRFEHS IYKSIHGYPE LLSLLLKWQI 700
    HNQGTAHTND GFFKYLVDGK RMSGDMNTSL GNCILASLIV KDLVDSLGVD 750
    AQLVNNGDDN VLICSVDDEE VVVKALYDHW MKYGFEVVAE QPVYITEQIE 800
    FCQMKPVFDG TQYVLVRNPT VTMSKDACSI TPFYTANSAR KWCRAVGEAG 850
    LSLTGGMPIK QAYYQCMIRN GINKGNIHKS KEFRYGLSYV LHHGKSDRKA 900
    RPISAATRYS FYLAFGYTPD EQTALEGYYD SLELEWTESR LGIPARTPEC 950
    LLLRLLPKIP LQPKSPTKPV QRTASKPDLP DSQWQQALAA PL 992
    Length:992
    Mass (Da):112,683
    Last modified:May 1, 1997 - v1
    Checksum:iC54AB9AFA91301A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55002 Genomic RNA. Translation: AAC97551.1.
    U55002 Genomic RNA. Translation: AAC97552.1.
    RefSeqiNP_068342.1. NC_002598.1.
    NP_068343.1. NC_002598.1.

    Genome annotation databases

    GeneIDi912246.
    912248.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55002 Genomic RNA. Translation: AAC97551.1 .
    U55002 Genomic RNA. Translation: AAC97552.1 .
    RefSeqi NP_068342.1. NC_002598.1.
    NP_068343.1. NC_002598.1.

    3D structure databases

    ProteinModelPortali P89034.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 912246.
    912248.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and infectivity of a full-length cDNA clone of panicum mosaic virus."
      Turina M., Maruoka M., Monis J., Jackson A.O., Scholthof K.B.
      Virology 241:141-155(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Panicovirus accumulation is governed by two membrane-associated proteins with a newly identified conserved motif that contributes to pathogenicity."
      Batten J.S., Turina M., Scholthof K.B.
      Virol. J. 3:12-12(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRDRP_PMVK
    AccessioniPrimary (citable) accession number: P89034
    Secondary accession number(s): P90334
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 426.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3