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P89034 (RDRP_PMVK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p112

Cleaved into the following chain:

  1. Protein p48
Gene names
ORF Names:ORF1
OrganismPanicum mosaic virus (strain United States/Kansas 109S) (PMV) [Reference proteome]
Taxonomic identifier652599 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaePanicovirus
Virus hostMuhlenbergia [TaxID: 58090]
Panicum virgatum (Switchgrass) [TaxID: 38727]

Protein attributes

Sequence length992 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable. Ref.2

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subcellular location

Host membrane Ref.2.

Miscellaneous

Readthrough of the terminator UAG occurs at position 426.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Ontologies

Keywords
   Biological processViral RNA replication
   Cellular componentHost membrane
Membrane
   Coding sequence diversityRNA suppression of termination
   LigandNucleotide-binding
   Molecular functionNucleotidyltransferase
RNA-directed RNA polymerase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processviral RNA genome replication

Inferred from electronic annotation. Source: InterPro

   Cellular_componenthost cell membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 992992RNA-directed RNA polymerase
PRO_0000399486
Chain1 – 425425Protein p48
PRO_0000399487

Regions

Domain656 – 772117RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P89034 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C54AB9AFA91301A2

FASTA992112,683
        10         20         30         40         50         60 
MESLIQHILS ATSSLSMPSV DSDKLQLLLT RFPQATLSWL SGIDGLSVHQ FKVVATHVIK 

        70         80         90        100        110        120 
ESYSHLSPSV AVLLAKPSDY YKLVVHGLTQ KQWNEFDDKV TDAPRTAISW LYNQILVVGQ 

       130        140        150        160        170        180 
PWMKSLNEGL KEYLPGWLHT CLRMLANLWF GAERVLHGIS HAVSDITTYQ PWMSCRRCVA 

       190        200        210        220        230        240 
HSPKESLLGE ATTTSNPRES SWFSWLLCGG VVAATVYGFY KWVTITETID RQDLAKQRPT 

       250        260        270        280        290        300 
HMQKCYEEVK ARLEEESKGF IHDRMEDELT KIVLEPAEID NDGKVLKSEV AQYLVKNHGR 

       310        320        330        340        350        360 
FVRSLVTMAK NEFAGVPKPT EANQLAVWRY LYRVCDKKGV NPSDTQKSIS AALPFVFLPS 

       370        380        390        400        410        420 
AYDQDQAITM NCDDTKKVLE RYADTFRHTT PLQKLVTNPL VGANWTAWAR SIFISDPETG 

       430        440        450        460        470        480 
LRFAKXGCIE KWQGVQCKRT RVRHPRLRCH FKDRDPKVRS IYRIAGLGDQ YEFGLHNNSA 

       490        500        510        520        530        540 
ANLERGLAER VYMVKNYKTD FVASLDPAFC PAPEPVRGIF KRLDKYKKEI VRRVGRKSPI 

       550        560        570        580        590        600 
TDEMFLSYYD GPQLTTYSKA VISLSERPVA VQDSYLKTFI KAEKLNLTLK TDPCPRVIQP 

       610        620        630        640        650        660 
RHPRYNVELG KYLKHIEHPI YKAIDRIWGG KTIFKGMNVE AMGAEIHKKM CKYSNPCAIG 

       670        680        690        700        710        720 
FDASRFDQHV SVEALRFEHS IYKSIHGYPE LLSLLLKWQI HNQGTAHTND GFFKYLVDGK 

       730        740        750        760        770        780 
RMSGDMNTSL GNCILASLIV KDLVDSLGVD AQLVNNGDDN VLICSVDDEE VVVKALYDHW 

       790        800        810        820        830        840 
MKYGFEVVAE QPVYITEQIE FCQMKPVFDG TQYVLVRNPT VTMSKDACSI TPFYTANSAR 

       850        860        870        880        890        900 
KWCRAVGEAG LSLTGGMPIK QAYYQCMIRN GINKGNIHKS KEFRYGLSYV LHHGKSDRKA 

       910        920        930        940        950        960 
RPISAATRYS FYLAFGYTPD EQTALEGYYD SLELEWTESR LGIPARTPEC LLLRLLPKIP 

       970        980        990 
LQPKSPTKPV QRTASKPDLP DSQWQQALAA PL 

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References

[1]"Nucleotide sequence and infectivity of a full-length cDNA clone of panicum mosaic virus."
Turina M., Maruoka M., Monis J., Jackson A.O., Scholthof K.B.
Virology 241:141-155(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Panicovirus accumulation is governed by two membrane-associated proteins with a newly identified conserved motif that contributes to pathogenicity."
Batten J.S., Turina M., Scholthof K.B.
Virol. J. 3:12-12(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55002 Genomic RNA. Translation: AAC97551.1.
U55002 Genomic RNA. Translation: AAC97552.1.
RefSeqNP_068342.1. NC_002598.1.
NP_068343.1. NC_002598.1.

3D structure databases

ProteinModelPortalP89034.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID912246.
912248.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_PMVK
AccessionPrimary (citable) accession number: P89034
Secondary accession number(s): P90334
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families