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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Panicum mosaic virus (strain United States/Kansas 109S) (PMV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.1 Publication

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p112
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiPanicum mosaic virus (strain United States/Kansas 109S) (PMV)
Taxonomic identifieri652599 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaePanicovirus
Virus hostiMuhlenbergia [TaxID: 58090]
Panicum virgatum (Switchgrass) [TaxID: 38727]
ProteomesiUP000001665 Componenti: Genome

Subcellular locationi

Host membrane 1 Publication

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 992992RNA-directed RNA polymerasePRO_0000399486Add
BLAST
Chaini1 – 425425Protein p48PRO_0000399487Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP89034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini656 – 772117RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P89034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLIQHILS ATSSLSMPSV DSDKLQLLLT RFPQATLSWL SGIDGLSVHQ
60 70 80 90 100
FKVVATHVIK ESYSHLSPSV AVLLAKPSDY YKLVVHGLTQ KQWNEFDDKV
110 120 130 140 150
TDAPRTAISW LYNQILVVGQ PWMKSLNEGL KEYLPGWLHT CLRMLANLWF
160 170 180 190 200
GAERVLHGIS HAVSDITTYQ PWMSCRRCVA HSPKESLLGE ATTTSNPRES
210 220 230 240 250
SWFSWLLCGG VVAATVYGFY KWVTITETID RQDLAKQRPT HMQKCYEEVK
260 270 280 290 300
ARLEEESKGF IHDRMEDELT KIVLEPAEID NDGKVLKSEV AQYLVKNHGR
310 320 330 340 350
FVRSLVTMAK NEFAGVPKPT EANQLAVWRY LYRVCDKKGV NPSDTQKSIS
360 370 380 390 400
AALPFVFLPS AYDQDQAITM NCDDTKKVLE RYADTFRHTT PLQKLVTNPL
410 420 430 440 450
VGANWTAWAR SIFISDPETG LRFAKXGCIE KWQGVQCKRT RVRHPRLRCH
460 470 480 490 500
FKDRDPKVRS IYRIAGLGDQ YEFGLHNNSA ANLERGLAER VYMVKNYKTD
510 520 530 540 550
FVASLDPAFC PAPEPVRGIF KRLDKYKKEI VRRVGRKSPI TDEMFLSYYD
560 570 580 590 600
GPQLTTYSKA VISLSERPVA VQDSYLKTFI KAEKLNLTLK TDPCPRVIQP
610 620 630 640 650
RHPRYNVELG KYLKHIEHPI YKAIDRIWGG KTIFKGMNVE AMGAEIHKKM
660 670 680 690 700
CKYSNPCAIG FDASRFDQHV SVEALRFEHS IYKSIHGYPE LLSLLLKWQI
710 720 730 740 750
HNQGTAHTND GFFKYLVDGK RMSGDMNTSL GNCILASLIV KDLVDSLGVD
760 770 780 790 800
AQLVNNGDDN VLICSVDDEE VVVKALYDHW MKYGFEVVAE QPVYITEQIE
810 820 830 840 850
FCQMKPVFDG TQYVLVRNPT VTMSKDACSI TPFYTANSAR KWCRAVGEAG
860 870 880 890 900
LSLTGGMPIK QAYYQCMIRN GINKGNIHKS KEFRYGLSYV LHHGKSDRKA
910 920 930 940 950
RPISAATRYS FYLAFGYTPD EQTALEGYYD SLELEWTESR LGIPARTPEC
960 970 980 990
LLLRLLPKIP LQPKSPTKPV QRTASKPDLP DSQWQQALAA PL
Length:992
Mass (Da):112,683
Last modified:May 1, 1997 - v1
Checksum:iC54AB9AFA91301A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55002 Genomic RNA. Translation: AAC97551.1.
U55002 Genomic RNA. Translation: AAC97552.1.
RefSeqiNP_068342.1. NC_002598.1.
NP_068343.1. NC_002598.1.

Genome annotation databases

GeneIDi912246.
912248.
KEGGivg:912246.
vg:912248.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55002 Genomic RNA. Translation: AAC97551.1.
U55002 Genomic RNA. Translation: AAC97552.1.
RefSeqiNP_068342.1. NC_002598.1.
NP_068343.1. NC_002598.1.

3D structure databases

ProteinModelPortaliP89034.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi912246.
912248.
KEGGivg:912246.
vg:912248.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and infectivity of a full-length cDNA clone of panicum mosaic virus."
    Turina M., Maruoka M., Monis J., Jackson A.O., Scholthof K.B.
    Virology 241:141-155(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Panicovirus accumulation is governed by two membrane-associated proteins with a newly identified conserved motif that contributes to pathogenicity."
    Batten J.S., Turina M., Scholthof K.B.
    Virol. J. 3:12-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRDRP_PMVK
AccessioniPrimary (citable) accession number: P89034
Secondary accession number(s): P90334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 1997
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 426.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.