P88946 (P88946_HHV8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: ORF K9 EMBL AAC57140.1
Organism	Human herpesvirus 8 type M EMBL AAC57140.1
Taxonomic identifier	435895 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Gene Ontology (GO)
Biological process	negative regulation of transcription, DNA-dependent Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB regulatory region DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Crebbp	P45481	6	EBI-936023,EBI-296306	From a different organism.

Sequences

	Sequence		Length	Mass (Da)
	P88946 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 3C6A4E48FD57521A	FASTA	449	48,460
	10 20 30 40 50 60 MDPGQRPNPF GAPGAIPKKP CLSQGSPGTS GSGAPCDEPS RSESPGEGPS GTGGSAAAGD 70 80 90 100 110 120 ITRQAVVAAI TEWSRTRQLR ISTGASEGKA SIKDWIVCQV NSGKFPGVEW EDEERTRFRI 130 140 150 160 170 180 PVTPLADPCF EWRRDGELGV VYIRERGNMP VDASFKGTRG RRRMLAALRR TRGLQEIGKG 190 200 210 220 230 240 ISQDGHHFLV FRVRKPEEEQ CVECGVVAGA VHDFNNMARL LQEGFFSPGQ CLPGEIVTPV 250 260 270 280 290 300 PSCTTAEGQE AVIDWGRLFI RMYYNGEQVH ELLTTSQSGC RISSALRRDP AVHYCAVGSP 310 320 330 340 350 360 GQVWLPNVPN LACEIAKREL CDTLDACAKG ILLTSSCNGI FCVCYHNGPV HFIGNTVPPD 370 380 390 400 410 420 SGPLLLPQGK PTRIFNPNTF LVGLANSPLP APSHVTCPLV KLWLGKPVAV GKLEPHAPSP 430 440 RDFAARCSNF SDACVVLEIM PKPLWDAMQ

References

[1]	"Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV." Moore P.S., Bashoff C., Weiss R.A., Chang Y. Science 274:1739-1744(1996) [PubMed: 8939871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed: 8962146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75698 Genomic DNA. Translation: AAC57140.1.
3D structure databases
ProteinModelPortal	P88946.
ModBase	Search...
Protein-protein interaction databases
IntAct	P88946. 1 interaction.
MINT	MINT-2824480.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001346. Interferon_reg_fact_DNA-bd_dom. IPR019471. Interferon_reg_factor-3. IPR017855. SMAD_dom-like. IPR008984. SMAD_FHA_domain. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00605. IRF. 1 hit. PF10401. IRF-3. 1 hit. [Graphical view]
SMART	SM00348. IRF. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS51507. IRF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P88946_HHV8

Accession

Primary (citable) accession number: P88946

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	October 19, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)