ORF 37 - Human herpesvirus 8 type M

Preferred order of sections

Names and origin

Protein names	Submitted name: ORF 37 EMBL AAC57119.1
Organism	Human herpesvirus 8 type M EMBL AAC57119.1
Taxonomic identifier	435895 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Human herpesvirus 8

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 3FHD Metal-binding PDB 3FHD
Technical term	3D-structure PDB 3FHD PDB 3POV
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro exonuclease activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

184

1

Magnesium PDB 3FHD

Metal binding

221

1

Magnesium PDB 3FHD

Metal binding

244

1

Magnesium PDB 3FHD

Metal binding

245

1

Magnesium; via carbonyl oxygen PDB 3FHD

Sequences

Sequence

Length

Mass (Da)

Tools

P88925 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: BC8A46991065AF9E
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FASTA

486

55,106

        10         20         30         40         50         60 
MEATPTPADL FSEDYLVDTL DGLTVDDQQA VLASLSFSKF LKHAKVRDWC AQAKIQPSMP 

        70         80         90        100        110        120 
ALRMAYNYFL FSKVGEFIGS EDVCNFFVDR VFGGVRLLDV ASVYAACSQM NAHQRHHICC 

       130        140        150        160        170        180 
LVERATSSQS LNPVWDALRD GIISSSKFHW AVKQQNTSKK IFSPWPITNN HFVAGPLAFG 

       190        200        210        220        230        240 
LRCEEVVKTL LATLLHPDET NCLDYGFMQS PQNGIFGVSL DFAANVKTDT EGRLQFDPNC 

       250        260        270        280        290        300 
KVYEIKCRFK YTFAKMECDP IYAAYQRLYE APGKLALKDF FYSISKPAVE YVGLGKLPSE 

       310        320        330        340        350        360 
SDYLVAYDQE WEACPRKKRK LTPLHNLIRE CILHNSTTES DVYVLTDPQD TRGQISIKAR 

       370        380        390        400        410        420 
FKANLFVNVR HSYFYQVLLQ SSIVEEYIGL DSGIPRLGSP KYYIATGFFR KRGYQDPVNC 

       430        440        450        460        470        480 
TIGGDALDPH VEIPTLLIVT PVYFPRGAKH RLLHQAANFW SRSAKDTFPY IKWDFSYLSA 


NVPHSP

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References

[1]	"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV." Moore P.S., Bashoff C., Weiss R.A., Chang Y. Science 274:1739-1744(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus." Dahlroth S.L., Gurmu D., Schmitzberger F., Engman H., Haas J., Erlandsen H., Nordlund P. FEBS J. 276:6636-6645(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
[5]	"Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff." Bagneris C., Briggs L.C., Savva R., Ebrahimi B., Barrett T.E. Nucleic Acids Res. 39:5744-5756(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U75698 Genomic DNA. Translation: AAC57119.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FHD	X-ray	1.85	A	1-486	[»]
3POV	X-ray	2.50	A	1-486	[»]

ProteinModelPortal

P88925.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-2824695.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.90.320.10. 1 hit.

InterPro

IPR011604. Exonuc_phg/RecB_C.
IPR001616. Herpes_alk_exo.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]

Pfam

PF01771. Herpes_alk_exo. 1 hit.
[Graphical view]

PRINTS

PR00924. ALKEXNUCLASE.

SUPFAM

SSF52980. Restrict_endonuc_II-like_core. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P88925.

Entry information

Entry name

P88925_HHV8

Accession

Primary (citable) accession number: P88925

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)