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P87724

- NSP1_ROTHU

UniProt

P87724 - NSP1_ROTHU

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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (isolate Human/India/116E/1986 G9-P8[11]-I1-Rx-Cx-Mx-A1-Nx-Tx-E1-Hx) (RV-A)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 7938 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name:
NS53
OrganismiRotavirus A (isolate Human/India/116E/1986 G9-P8[11]-I1-Rx-Cx-Mx-A1-Nx-Tx-E1-Hx) (RV-A)
Taxonomic identifieri42567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Non-structural protein 1PRO_0000369074Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8181RNA-binding By similarityAdd
BLAST
Regioni82 – 17695Important for cytoskeleton localization By similarityAdd
BLAST
Regioni313 – 486174Interaction with IRF3 By similarityAdd
BLAST

Domaini

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similaritiesi

Belongs to the rotavirus A NSP1 family.

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87724-1 [UniParc]FASTAAdd to Basket

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MATFKDACYH YKRINKLNQT VLKLGVNDTW RPSPPTKYKG WCLDCCQHTD    50
LTYCRGCTIY HVCQWCSQYG RCFLDDEPHL LRMRTFKNEV TKDNLKNLID 100
MYNTLFPITQ KIIHRFINNT RQHKCRNECM TQWYNHLLMP ITLQSLSIEL 150
DGDVYYIFGY YDSMNNINQT PFSFTNLVDI YDKLLLDDVN FVRMSFLPTS 200
LQREYALRYF SKSRFISEQR KCVNDSHFSI NVLENLYNPN FKVQITRNCS 250
ELSVDWNEAC KLVKNVSAYF DILKTSHVEF YSVSTRCRIF TRCKLEMASK 300
LIKPNYVTSN HKTLATEVRN CKWCSINNSY TVWNDFRIKK IYNNIFSFLR 350
ALVKSNVNIG HCSSQEKIYE YVENVLNVCD DKRWKTSIME IFNCLEPVEL 400
NDVKYVLFNY EINWDVINVL IHSIGKVPQI LTLENVITII QSIVYEWFDI 450
TYMRNTPMVT FTIDKLRRLH IGLKTVDSDS GISDVE 486
Length:486
Mass (Da):57,596
Last modified:May 1, 1997 - v1
Checksum:i39FFD284F291ADC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85999 mRNA. Translation: AAB46986.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85999 mRNA. Translation: AAB46986.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002148. Rotavirus_NSP1.
[Graphical view ]
Pfami PF00981. Rota_NS53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis demonstrates that VP6, NSP1 and NSP4 genes of Indian neonatal rotavirus strain 116E are of human origin."
    Cunliffe N.A., Das B.K., Ramachandran M., Bhan M.K., Glass R.I., Gentsch J.R.
    Virus Genes 15:39-44(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNSP1_ROTHU
AccessioniPrimary (citable) accession number: P87724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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