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P87724

- NSP1_ROTHU

UniProt

P87724 - NSP1_ROTHU

Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (isolate Human/India/116E/1986 G9-P8[11]-I1-Rx-Cx-Mx-A1-Nx-Tx-E1-Hx) (RV-A)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri42 – 7938Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
    2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
    3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 1
    Short name:
    NSP1
    Alternative name(s):
    NCVP2
    Non-structural RNA-binding protein 53
    Short name:
    NS53
    OrganismiRotavirus A (isolate Human/India/116E/1986 G9-P8[11]-I1-Rx-Cx-Mx-A1-Nx-Tx-E1-Hx) (RV-A)
    Taxonomic identifieri42567 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-KW
    2. host cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Non-structural protein 1PRO_0000369074Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8181RNA-bindingBy similarityAdd
    BLAST
    Regioni82 – 17695Important for cytoskeleton localizationBy similarityAdd
    BLAST
    Regioni313 – 486174Interaction with IRF3By similarityAdd
    BLAST

    Domaini

    The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus A NSP1 family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri42 – 7938Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR002148. Rotavirus_NSP1.
    [Graphical view]
    PfamiPF00981. Rota_NS53. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P87724-1 [UniParc]FASTAAdd to Basket

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    MATFKDACYH YKRINKLNQT VLKLGVNDTW RPSPPTKYKG WCLDCCQHTD    50
    LTYCRGCTIY HVCQWCSQYG RCFLDDEPHL LRMRTFKNEV TKDNLKNLID 100
    MYNTLFPITQ KIIHRFINNT RQHKCRNECM TQWYNHLLMP ITLQSLSIEL 150
    DGDVYYIFGY YDSMNNINQT PFSFTNLVDI YDKLLLDDVN FVRMSFLPTS 200
    LQREYALRYF SKSRFISEQR KCVNDSHFSI NVLENLYNPN FKVQITRNCS 250
    ELSVDWNEAC KLVKNVSAYF DILKTSHVEF YSVSTRCRIF TRCKLEMASK 300
    LIKPNYVTSN HKTLATEVRN CKWCSINNSY TVWNDFRIKK IYNNIFSFLR 350
    ALVKSNVNIG HCSSQEKIYE YVENVLNVCD DKRWKTSIME IFNCLEPVEL 400
    NDVKYVLFNY EINWDVINVL IHSIGKVPQI LTLENVITII QSIVYEWFDI 450
    TYMRNTPMVT FTIDKLRRLH IGLKTVDSDS GISDVE 486
    Length:486
    Mass (Da):57,596
    Last modified:May 1, 1997 - v1
    Checksum:i39FFD284F291ADC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85999 mRNA. Translation: AAB46986.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85999 mRNA. Translation: AAB46986.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002148. Rotavirus_NSP1.
    [Graphical view ]
    Pfami PF00981. Rota_NS53. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis demonstrates that VP6, NSP1 and NSP4 genes of Indian neonatal rotavirus strain 116E are of human origin."
      Cunliffe N.A., Das B.K., Ramachandran M., Bhan M.K., Glass R.I., Gentsch J.R.
      Virus Genes 15:39-44(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNSP1_ROTHU
    AccessioniPrimary (citable) accession number: P87724
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3