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P87630

- DUT_CWPXG

UniProt

P87630 - DUT_CWPXG

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Cowpox virus (strain GRI-90 / Grishak) (CPV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT
    ORF Names:G2L
    OrganismiCowpox virus (strain GRI-90 / Grishak) (CPV)
    Taxonomic identifieri265871 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]
    Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
    Homo sapiens (Human) [TaxID: 9606]
    Loxodonta africana (African elephant) [TaxID: 9785]
    Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
    Mus musculus (Mouse) [TaxID: 10090]
    Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182946Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP87630.
    SMRiP87630. Positions 7-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P87630-1 [UniParc]FASTAAdd to Basket

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    MFNMNINSPV RFVKETNRAK SPTRQSPGAA GYDLYSAYDY TIPPGERQLI    50
    KTDISMSMPK FCYGRIAPRS GLSLKGIDIG GGVIDEDYRG NIGVILINNG 100
    KCTFNVNTGD RIAQLIYQRI YYPELEEVQS LDSTDRGAQG FGSTGLR 147
    Length:147
    Mass (Da):16,255
    Last modified:May 1, 1997 - v1
    Checksum:iD562BC4F4827F1FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94355 Genomic DNA. Translation: CAA64116.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94355 Genomic DNA. Translation: CAA64116.1 .

    3D structure databases

    ProteinModelPortali P87630.
    SMRi P87630. Positions 7-131.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure-function and organization of cowpox virus strain GRI-90 complete genome."
      Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V., Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_CWPXG
    AccessioniPrimary (citable) accession number: P87630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3