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Protein

Vitellogenin-1

Gene

VTG1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-1
Alternative name(s):
Minor vitellogenin
Vitellogenin I
Cleaved into the following 4 chains:
Alternative name(s):
Lipovitellin I
Short name:
LVI
Phosvitin
Short name:
PV
Alternative name(s):
Lipovitellin II
Short name:
LVII
Gene namesi
Name:VTG1
Synonyms:VTGI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Pathology & Biotechi

Protein family/group databases

Allergomei8172. Gal d 6.
8173. Gal d 6.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 19121897Vitellogenin-1PRO_0000041552Add
BLAST
Chaini16 – 11391124Lipovitellin-1By similarityPRO_0000041553Add
BLAST
Chaini1140 – 1391252PhosvitinBy similarityPRO_0000041554Add
BLAST
Chaini1392 – 1627236Lipovitellin-2By similarityPRO_0000041555Add
BLAST
Chaini1628 – 1912285YGP42PRO_0000041556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence analysis
Glycosylationi1206 – 12061N-linked (GlcNAc...)Sequence analysis
Glycosylationi1375 – 13751N-linked (GlcNAc...)Sequence analysis
Glycosylationi1662 – 16621N-linked (GlcNAc...)Sequence analysis
Glycosylationi1698 – 16981N-linked (GlcNAc...)Sequence analysis
Glycosylationi1703 – 17031N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosvitin, an egg yolk storage protein, is one of the most highly phosphorylated (10%) proteins in nature.
Cathepsin D is responsible for intraoocytic processing of vitellogenin.
May contain intrachain disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP87498.
PRIDEiP87498.

Expressioni

Tissue specificityi

Produced by the liver, secreted into the blood and then sequestered by receptor mediated endocytosis into growing oocytes, where it is generally cleaved, giving rise to the respective yolk components.

Inductioni

By steroids (estrogen).

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032611.

Structurei

3D structure databases

ProteinModelPortaliP87498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 663640VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini1640 – 1846207VWFDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1093 – 110412Poly-SerAdd
BLAST
Compositional biasi1150 – 1299150Ser-richAdd
BLAST
Compositional biasi1359 – 139739Ser-richAdd
BLAST
Compositional biasi1612 – 16154Poly-Ser

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
HOGENOMiHOG000172510.
InParanoidiP87498.
PhylomeDBiP87498.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 1 hit.
2.20.80.10. 2 hits.
2.20.90.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015258. Vitellinogen_b-sht_shell.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF09175. DUF1944. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM01170. DUF1944. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 3 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLISALVL TLVGSQHLNY QPDFGENKVY TYNYESILFS GIPEKGLART
60 70 80 90 100
GIRIRSEVEI SGIGPKLCLI RIHSIEAAEY NGIWPTSSFS RSLKLTQALT
110 120 130 140 150
GQLSIPIKFE YSNGHVGNLM APDSVSDDGL NIYRGILNIL ELSLKKMQHS
160 170 180 190 200
YSIQEAGIGG ICNTTYAIQE NKKANLVDVT KSKDLNSCEE KVQVVTGSAY
210 220 230 240 250
TQPCQTCQQR NKNSRATATY NYKIKYTHNE AVITQAEVEE VHQFTPFHEI
260 270 280 290 300
TGGNAIVEAR QKLALIEVQK QVAEVPPKEF QKRGSLQYQF GSELLQLPVH
310 320 330 340 350
LFKIKDVERQ IEERLQDLVE TTYEQLPSDA PAKALKLMHL LRAANEENYE
360 370 380 390 400
SVWKQFSSRP AYRRYLLDLL PAAASHRSLR FLRHKMERQE LTNWEIAQTV
410 420 430 440 450
LVALHSSSPT QEVMEEATLI VKKHCPRSSS VLRKVCLLSY ASLCHKRCSS
460 470 480 490 500
PYSCSECLQV FHVFAGEALG KSNIEEVLLA LKALGNVGHP ASIKHIKKFL
510 520 530 540 550
PGYAAGASEL PLKVHETAVM ALKSIGMRDP QMVQAITLEI FLNHKIHPRI
560 570 580 590 600
RMLAAVVLLE TKPGLPILMI LVDAVLKEPS MQVASFIYSH LRALGRSTAP
610 620 630 640 650
DLQMMASACR MAVRALSPKF DRSGYQFSKV FRFSMFKEFL MSGLAAKYFV
660 670 680 690 700
LNNAGSLIPT MAVSQLRTHF LGRVADPIEV GIAAEGLQEM FVRGYSPDKD
710 720 730 740 750
WETNYDFREI LKKLSDWKAL PRDKPFASGY LKMFGQELLF GRLDKDTLQN
760 770 780 790 800
VLQVWYGPDE KIPSIRRLIS SLQTGIGRQW TKALLLSEIR CIVPTCVGFP
810 820 830 840 850
METSFYYSSV TKVAGNVQAQ ITPSPRSDFR LTELLNSNVR LRSKMSLSMA
860 870 880 890 900
KHMTFVIGIN TNMIQAGLEA HTKVNAHVPV NVVATIQMKE KSIKAEIPPC
910 920 930 940 950
KEETNLIIVS SKTFAVTRNI EDLAASKMTP VLLPEAVPDI MKMSFDSDSA
960 970 980 990 1000
SGETDNIRDR QSVEDVSSGN SFSFGHPSSG KEPFIQSMCS NASTFGVQVC
1010 1020 1030 1040 1050
IEKKSVHAAF IRNVPLYNAI GEHALRMSFK PVYSDVPIEK IQVTIQAGDQ
1060 1070 1080 1090 1100
APTKMVRLVT FEDPERQESS RKEVMKRVKK ILDDTDNQAT RNSRSSSSSA
1110 1120 1130 1140 1150
SSISESSEST TSTPSSSDSD NRASQGDPQI NLKSRQSKAN EKKFYPFGDS
1160 1170 1180 1190 1200
SSSGSSSSSS SSSSSSSDSS SSSRSSSSSD SSSSSSSSSS SSSSKSKSSS
1210 1220 1230 1240 1250
RSSKSNRSSS SSNSKDSSSS SSKSNSKGSS SSSSKASGTR QKAKKQSKTT
1260 1270 1280 1290 1300
SFPHASAAEG ERSVHEQKQE TQSSSSSSSR ASSNSRSTSS STSSSSESSG
1310 1320 1330 1340 1350
VSHRQWKQDR EAETKRVKSQ FNSHSSYDIP NEWETYLPKV YRLRFRSAHT
1360 1370 1380 1390 1400
HWHSGHRTSS SSSSSSSESG SSHSNSSSSD SSSRRSHMSD SSSSSSSHRH
1410 1420 1430 1440 1450
GEKAAHSSRR SPTSRAASAH HRPGSSLTRE RNFLGDVIPP GITIVAQAVR
1460 1470 1480 1490 1500
SDNRNQGYQA TAYVRSDAAK VDVQLVVVQL AETNWKACAD AVILPLKAQA
1510 1520 1530 1540 1550
RMRWGKECRD YRIAALATTG QMARKLAVQL KVQWGIIPSW IKKTSTALMR
1560 1570 1580 1590 1600
YVPGVALVLG FSEAHQRNPS RELIVRAVAT SPRSIDTVIK VPGVTLYYQG
1610 1620 1630 1640 1650
LRVPFTLALG ASSSSYETRD ITAWNFLPEI ASQIAQEDQS TCEVSKGDFK
1660 1670 1680 1690 1700
TFDRMSFTCS FNKSCNVVVA QDCTEHPKFI ITTRKVDHQS LSREVHINTS
1710 1720 1730 1740 1750
SANITICPAA DSSLLVTCNK ESVLSDSGVS EYEKDNIKIY KNGKTVIVEA
1760 1770 1780 1790 1800
PIHGLKNVNF DGEILKVTVA SWMRGKTCGV CGNNDREKHN ELLMPNHKLA
1810 1820 1830 1840 1850
HSCSAFVHSW VLLEETCSGG CKLQRRYVKL NRNPTIDGEE STCYSVDPVL
1860 1870 1880 1890 1900
KCMKDCTPIE KTSVKVGFHC FPKATAVSLL EWQRSSDKKS ASEDVVESVD
1910
ADIDCTCTGD CS
Length:1,912
Mass (Da):210,630
Last modified:May 1, 1997 - v1
Checksum:i89BA6273D6492E51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89547 mRNA. Translation: BAA13973.1.
PIRiT29088.
RefSeqiNP_001004408.1. NM_001004408.2.
UniGeneiGga.4125.

Genome annotation databases

GeneIDi424547.
KEGGigga:424547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89547 mRNA. Translation: BAA13973.1.
PIRiT29088.
RefSeqiNP_001004408.1. NM_001004408.2.
UniGeneiGga.4125.

3D structure databases

ProteinModelPortaliP87498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032611.

Protein family/group databases

Allergomei8172. Gal d 6.
8173. Gal d 6.0101.

Proteomic databases

PaxDbiP87498.
PRIDEiP87498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi424547.
KEGGigga:424547.

Organism-specific databases

CTDi559475.

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
HOGENOMiHOG000172510.
InParanoidiP87498.
PhylomeDBiP87498.

Miscellaneous databases

PROiP87498.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 1 hit.
2.20.80.10. 2 hits.
2.20.90.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015258. Vitellinogen_b-sht_shell.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF09175. DUF1944. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM01170. DUF1944. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 3 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIT1_CHICK
AccessioniPrimary (citable) accession number: P87498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.