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Protein
Submitted name:

Cathepsin D

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96PROSITE-ProRule annotation1
Active sitei283PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin DImported (EC:3.4.23.5Imported)
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)Imported
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiP87370.

Structurei

3D structure databases

ProteinModelPortaliP87370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 395Peptidase A1InterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG000482.

Family and domain databases

CDDicd05490. Cathepsin_D2. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033736. Cathepsin_chordata.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF487. PTHR13683:SF487. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

P87370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLYLCLFA ALALASDALV RIPLRKFRSI RRTLTDSGRA AEELLAGQEH
60 70 80 90 100
TKYNNLGFPS SSNGPTPETL KNFMDAQYYG EIGLGTPVQT FTVVFDTGSS
110 120 130 140 150
NLWVPSVHCS FTDIACLLHH KYNGAKSSTY VKNGTAFAIQ YGSGSLSGYL
160 170 180 190 200
SQDTCTIGGL SIEDQGFGEA IKQPGVAFIA AKFDGILGMA YPRISVDGVA
210 220 230 240 250
PPFDNIMSQK KVEQNVFSFY LNRNPDSEPG GELLLGGTDP KYYSGDFQYL
260 270 280 290 300
DVSRQAYWQI HMDGMGVGSQ LSLCKGGCEA IVDTGTSLIT GPAAEVKALQ
310 320 330 340 350
RAIGATPLIQ GEYMVNCDKI PTMPVITFNL GGQSYSLTAE QYVLKESQAG
360 370 380 390
KTICLSGFMG LDIPAPAGPL WILGDVFIGQ YYTVFDRDNN RVGFAKSK
Length:398
Mass (Da):42,973
Last modified:May 1, 1997 - v1
Checksum:i23C94FB3F5EC99D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90321 mRNA. Translation: AAC60301.1.
RefSeqiNP_001118183.1. NM_001124711.1.
UniGeneiOmy.11433.

Genome annotation databases

GeneIDi100136761.

Similar proteinsi

Entry informationi

Entry nameiP87370_ONCMY
AccessioniPrimary (citable) accession number: P87370
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation