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Protein
Submitted name:

Cyclops

Gene

ndr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • cell fate commitment Source: ZFIN
  • cell fate determination Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • embryonic eye morphogenesis Source: ZFIN
  • embryonic heart tube morphogenesis Source: ZFIN
  • floor plate development Source: ZFIN
  • floor plate formation Source: ZFIN
  • growth Source: InterPro
  • heart looping Source: ZFIN
  • hypothalamus development Source: ZFIN
  • inner ear development Source: ZFIN
  • mesendoderm development Source: ZFIN
  • mesoderm formation Source: ZFIN
  • notochord development Source: ZFIN
  • notochord formation Source: ZFIN
  • optic placode formation involved in camera-type eye formation Source: ZFIN
  • organ morphogenesis Source: ZFIN
  • regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  • retina development in camera-type eye Source: ZFIN
  • retinal ganglion cell axon guidance Source: ZFIN
  • Spemann organizer formation Source: ZFIN
  • telencephalon development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CyclopsImported
Submitted name:
Znr-1Imported
Gene namesi
Name:ndr2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-181. ndr2.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 501479Sequence analysisPRO_5005929056Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000058968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini378 – 501124TGF_BETA_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113815.
OrthoDBiEOG7DFXD1.
PhylomeDBiP87358.
TreeFamiTF351786.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHALGVARLA CYCQLLLLGV FGKHTRYRHN NYNSLRNMSH RMHLPTYMMH
60 70 80 90 100
LYRHYKMNQT RIPAESLEHE HADTIRSIMS KNVLNNDNHY VAIFDLSPVL
110 120 130 140 150
SERQIQAAEL RIRVPRDLHP DGLTLELQHQ QGAPCPRHQP CPKSQSLGLL
160 170 180 190 200
PEESLLSVTQ HWRVYNVTNL LLHWPRPRTS PRSRVKTKRP AAAPGGKEIH
210 220 230 240 250
SGPRRPAAAP GGQELQRRPR RPAVAPEEQE LPSRPRRPAV APGAQELQSG
260 270 280 290 300
PQRPAAAPGG QKIQNRPRRP SAAPKGQEVQ SRPSRPATAP RGQELQSAPQ
310 320 330 340 350
RPVVAPGGRE IHSRPWLPAA TPGGQEIQNG TQKHRAMLLL FSEQQDGASL
360 370 380 390 400
LHTAGASKFL FSRNKKEVKR GRALRSRRGR RGPPVRSPEL QRTPLHKSTT
410 420 430 440 450
CRRVDMHVDF NQIGWGSWIV FPKKYNAYRC EGACPNPLGE ELRPTNHAYM
460 470 480 490 500
QSLLKYHHPS RVPASCCAPT RTSALSMLYY ENGEMILRHH EDMQVEECGC

L
Length:501
Mass (Da):56,558
Last modified:June 1, 1998 - v2
Checksum:iA3D70B15ED6796FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87758 mRNA. Translation: AAB95625.1.
AF002219 mRNA. Translation: AAC34361.2.
RefSeqiNP_624359.1. NM_139133.1.
UniGeneiDr.18289.

Genome annotation databases

GeneIDi30292.
KEGGidre:30292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87758 mRNA. Translation: AAB95625.1.
AF002219 mRNA. Translation: AAC34361.2.
RefSeqiNP_624359.1. NM_139133.1.
UniGeneiDr.18289.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000058968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30292.
KEGGidre:30292.

Organism-specific databases

CTDi30292.
ZFINiZDB-GENE-990415-181. ndr2.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113815.
OrthoDBiEOG7DFXD1.
PhylomeDBiP87358.
TreeFamiTF351786.

Miscellaneous databases

NextBioi20806735.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cheng A.M.S., Sampath K., Erter C.E., Wright C.V.E.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry."
    Rebagliati M.R., Toyama R., Fricke C., Haffter P., Dawid I.B.
    Dev. Biol. 199:261-272(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "cyclops encodes a nodal-related factor involved in midline signaling."
    Rebagliati M.R., Toyama R., Haffter P., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 95:9932-9937(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Rebagliati M.R.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP87358_DANRE
AccessioniPrimary (citable) accession number: P87358
Secondary accession number(s): Q9PSU9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.