P87358 (P87358_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cyclops EMBL AAC34361.2

Submitted name:
Nodal-related 2 Ensembl ENSDARP00000058968
Submitted name:
Znr-1 EMBL AAB95625.1

Gene names

Name:

ndr2 Ensembl ENSDARP00000058968 ZFIN ZDB-GENE-990415-181

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAB95625.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS015615
Molecular function	Growth factor SAAS SAAS015615 RuleBase RU000354
PTM	Disulfide bond SAAS SAAS015615
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Spemann organizer formation Inferred from mutant phenotype. Source: ZFIN cell fate determination Inferred from mutant phenotype. Source: ZFIN dorsal/ventral pattern formation Inferred from direct assay. Source: ZFIN embryonic eye morphogenesis Inferred from mutant phenotype. Source: ZFIN floor plate formation Inferred from mutant phenotype. Source: ZFIN growth Inferred from electronic annotation. Source: InterPro heart looping Inferred from mutant phenotype. Source: ZFIN hypothalamus development Inferred from mutant phenotype. Source: ZFIN mesendoderm development Inferred from mutant phenotype. Source: ZFIN mesoderm formation Inferred from mutant phenotype. Source: ZFIN notochord formation Inferred from direct assay. Source: ZFIN regulation of BMP signaling pathway involved in heart jogging Inferred from mutant phenotype. Source: ZFIN retina development in camera-type eye Inferred from mutant phenotype. Source: ZFIN retinal ganglion cell axon guidance Inferred from mutant phenotype. Source: ZFIN telencephalon development Inferred from mutant phenotype. Source: ZFIN
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P87358 [UniParc]. Last modified June 1, 1998. Version 2. Checksum: A3D70B15ED6796FD	FASTA	501	56,558
	10 20 30 40 50 60 MHALGVARLA CYCQLLLLGV FGKHTRYRHN NYNSLRNMSH RMHLPTYMMH LYRHYKMNQT 70 80 90 100 110 120 RIPAESLEHE HADTIRSIMS KNVLNNDNHY VAIFDLSPVL SERQIQAAEL RIRVPRDLHP 130 140 150 160 170 180 DGLTLELQHQ QGAPCPRHQP CPKSQSLGLL PEESLLSVTQ HWRVYNVTNL LLHWPRPRTS 190 200 210 220 230 240 PRSRVKTKRP AAAPGGKEIH SGPRRPAAAP GGQELQRRPR RPAVAPEEQE LPSRPRRPAV 250 260 270 280 290 300 APGAQELQSG PQRPAAAPGG QKIQNRPRRP SAAPKGQEVQ SRPSRPATAP RGQELQSAPQ 310 320 330 340 350 360 RPVVAPGGRE IHSRPWLPAA TPGGQEIQNG TQKHRAMLLL FSEQQDGASL LHTAGASKFL 370 380 390 400 410 420 FSRNKKEVKR GRALRSRRGR RGPPVRSPEL QRTPLHKSTT CRRVDMHVDF NQIGWGSWIV 430 440 450 460 470 480 FPKKYNAYRC EGACPNPLGE ELRPTNHAYM QSLLKYHHPS RVPASCCAPT RTSALSMLYY 490 500 ENGEMILRHH EDMQVEECGC L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry." Rebagliati M.R., Toyama R., Fricke C., Haffter P., Dawid I.B. Dev. Biol. 199:261-272(1998) [PubMed: 9698446] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"cyclops encodes a nodal-related factor involved in midline signaling." Rebagliati M.R., Toyama R., Haffter P., Dawid I.B. Proc. Natl. Acad. Sci. U.S.A. 95:9932-9937(1998) [PubMed: 9707578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000058968.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000058968.
[5]	Rebagliati M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	Cheng A.M.S., Sampath K., Erter C.E., Wright C.V.E. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CABZ01080695 Genomic DNA. No translation available. CABZ01080696 Genomic DNA. No translation available. U87758 mRNA. Translation: AAB95625.1. AF002219 mRNA. Translation: AAC34361.2.
IPI	IPI00495715.
RefSeq	NP_624359.1. NM_139133.1.
UniGene	Dr.18289.
3D structure databases
HSSP	HSSP built from PDB template 1NYS based on UniProtKB P08476.
ProteinModelPortal	P87358.
ModBase	Search...
Protein-protein interaction databases
STRING	P87358.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000058969; ENSDARP00000058968; ENSDARG00000040299.
GeneID	30292.
KEGG	dre:30292.
Organism-specific databases
CTD	30292.
ZFIN	ZDB-GENE-990415-181. ndr2.
Phylogenomic databases
eggNOG	fiNOG09857.
GeneTree	ENSGT00600000084167.
HOGENOM	HBG713475.
OrthoDB	EOG4NGGNG.
Gene expression databases
ArrayExpress	P87358.
Bgee	P87358.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P87358_DANRE

Accession

Primary (citable) accession number: P87358
Secondary accession number(s): Q9PSU9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)