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Protein

Myelin basic protein

Gene

mbp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Have a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Alternative name(s):
Myelin A1 protein
Gene namesi
Name:mbp
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 176175Myelin basic proteinPRO_0000158997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei25 – 251CitrullineBy similarity
Modified residuei33 – 331CitrullineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei97 – 971Deamidated asparagineBy similarity
Modified residuei103 – 1031PhosphothreonineBy similarity
Modified residuei108 – 1081Deamidated glutamineBy similarity
Modified residuei111 – 1111Symmetric dimethylarginineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei171 – 1711PhosphoserineBy similarity
Modified residuei176 – 1761CitrullineBy similarity

Post-translational modificationi

As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi100427. 3 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

HOVERGENiHBG008347.
KOiK17269.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQKHSRGH GSKQMATAST YDHSRHGYGA HGRHRDSGLL DSLGRFFGGE
60 70 80 90 100
RSVPRKGSGK EVHMSRSGYL SSSPQRSPYH AHGRHVDDNP VVHFFRNIVS
110 120 130 140 150
PRTPPPSQPK RGFSRFSWGA ENHKPYYGGY GSRSLEHHKS SYKGYKDPHR
160 170
EGHGSLSRIF KLGGQRSRSS SPMARR
Length:176
Mass (Da):19,720
Last modified:January 23, 2007 - v3
Checksum:iD30B13DA3EB29F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000736 mRNA. Translation: BAA19174.1.
BC129777 mRNA. Translation: AAI29778.1.
RefSeqiNP_001083760.1. NM_001090291.1.
UniGeneiXl.25724.

Genome annotation databases

GeneIDi399102.
KEGGixla:399102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000736 mRNA. Translation: BAA19174.1.
BC129777 mRNA. Translation: AAI29778.1.
RefSeqiNP_001083760.1. NM_001090291.1.
UniGeneiXl.25724.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi100427. 3 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399102.
KEGGixla:399102.

Organism-specific databases

CTDi4155.

Phylogenomic databases

HOVERGENiHBG008347.
KOiK17269.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
ProtoNetiSearch...

Entry informationi

Entry nameiMBP_XENLA
AccessioniPrimary (citable) accession number: P87346
Secondary accession number(s): A2VDD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.