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Protein

Protein msp1, mitochondrial

Gene

msp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi270 – 2778GTPSequence analysis
Nucleotide bindingi370 – 3745GTPSequence analysis
Nucleotide bindingi438 – 4414GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • mitochondrial fusion Source: PomBase
  • mitochondrial genome maintenance Source: PomBase
  • mitochondrial inner membrane fusion Source: PomBase
  • mitochondrion organization Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein msp1, mitochondrial
Gene namesi
Name:msp1
ORF Names:SPBC1718.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1718.06.
PomBaseiSPBC1718.06. msp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini79 – 857Mitochondrial matrixSequence analysis
Transmembranei86 – 10318Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini104 – 903800Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7878MitochondrionSequence analysisAdd
BLAST
Chaini79 – 903825Protein msp1, mitochondrialPRO_0000007402Add
BLAST

Proteomic databases

MaxQBiP87320.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

BioGridi276392. 1 interaction.
MINTiMINT-4693250.

Structurei

3D structure databases

ProteinModelPortaliP87320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini260 – 531272Dynamin-type GAdd
BLAST
Domaini805 – 89894GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000206760.
InParanoidiP87320.
OMAiYVGVVCK.
OrthoDBiEOG7ZD23R.
PhylomeDBiP87320.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 2 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISWFLSRF RIRTVAPSSF LKPRGLVYRP SQIRRRVSLL SLSGFHPYRA
60 70 80 90 100
YSILGPKTPT AFNSANTVRF FSFSSISRLV FRSLRLPVAG FSLVAGGAAY
110 120 130 140 150
IGAQVQRASD YTKDIFDKTF GILDSTWEKT RETVASVTNV QLPEISMPLW
160 170 180 190 200
LEKILRLDEE SAERRRVLQA ERAKEHRSNS NDKQKSSDND EDPNDTTVGI
210 220 230 240 250
GAALAASILS VDSVDGEDTL TADEKRKLAQ ESKEDRMMLF TKKMIEIRNI
260 270 280 290 300
LQDIQDNNSA VTLPSIVVIG SQSSGKSSVL EAIVGHEFLP KGSNMVTRRP
310 320 330 340 350
IELTLVHSAD TAIPYGEFSG VQLGKITDFS KIQHILTDLN MAVPSSQGVD
360 370 380 390 400
DNPIRLTIYA SHIPNLSLID LPGYIQIHSE DQPADLDMKI SKLCEKYIRE
410 420 430 440 450
PNIILAVCAA DVDLANSAAL RASRRVDPLG LRTIGVVTKM DLVPPSKAIS
460 470 480 490 500
ILHNNNYPLH YGYIGVISRI VPTGRFSAGQ NLTDLVSTQE NSYFSTHQQF
510 520 530 540 550
ADARIGNYLG IQSLRKCLIN VLEYTMSKNL QHTADSIRTE LEECNYQYKV
560 570 580 590 600
QYNDRVLTAD SYIAEGLDIF KAAFKEFTQK FGKSEVRDLL KSSLNEKVMD
610 620 630 640 650
LLAERYWTDD DISNWSKHTN ALDEHWKYKL DSCVSTLTRM GLGRVSTLLV
660 670 680 690 700
TDSISKCIDE ITKASPFADH PAAMQYIMNA AQDILRRRFH ATSEQVENCV
710 720 730 740 750
KPYKYDVEVN DDEWKSSRGQ AEKLLQRELG LCQSALEKIK NAVGSRRMNQ
760 770 780 790 800
VLQYLEEQKT SSEPLPASYS TALLEQGRML QYLKMREDIL KLRISVLKSR
810 820 830 840 850
ACKHKEAKYT CPEIFLNAVS DKLVNTAVLF INIELLSEFY YQFPRELDQR
860 870 880 890 900
LIHSLSSEQL NAFVNENPRL KSQLQLQHKR QCLELALQKI NSLVILEQQA

DSD
Length:903
Mass (Da):101,901
Last modified:August 14, 2001 - v2
Checksum:i1717AA423C6E8177
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti869 – 8691R → L in CAA69196 (PubMed:9790976).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07891 Genomic DNA. Translation: CAA69196.1.
CU329671 Genomic DNA. Translation: CAB75996.1.
PIRiJE0327.
T50334.
RefSeqiNP_596452.1. NM_001022371.2.

Genome annotation databases

EnsemblFungiiSPBC1718.06.1; SPBC1718.06.1:pep; SPBC1718.06.
GeneIDi2539844.
KEGGispo:SPBC1718.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07891 Genomic DNA. Translation: CAA69196.1.
CU329671 Genomic DNA. Translation: CAB75996.1.
PIRiJE0327.
T50334.
RefSeqiNP_596452.1. NM_001022371.2.

3D structure databases

ProteinModelPortaliP87320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276392. 1 interaction.
MINTiMINT-4693250.

Proteomic databases

MaxQBiP87320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1718.06.1; SPBC1718.06.1:pep; SPBC1718.06.
GeneIDi2539844.
KEGGispo:SPBC1718.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC1718.06.
PomBaseiSPBC1718.06. msp1.

Phylogenomic databases

HOGENOMiHOG000206760.
InParanoidiP87320.
OMAiYVGVVCK.
OrthoDBiEOG7ZD23R.
PhylomeDBiP87320.

Miscellaneous databases

NextBioi20800991.
PROiP87320.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 2 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance."
    Pelloquin L., Belenguer P., Menon Y., Ducommun B.
    Biochem. Biophys. Res. Commun. 251:720-726(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Msp1p is an intermembrane space dynamin-related protein that mediates mitochondrial fusion in a Dnm1p-dependent manner in S. pombe."
    Guillou E., Bousquet C., Daloyau M., Emorine L.J., Belenguer P.
    FEBS Lett. 579:1109-1116(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMSP1_SCHPO
AccessioniPrimary (citable) accession number: P87320
Secondary accession number(s): Q9P7N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: December 9, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.