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Protein

Protein hir1

Gene

hip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.2 Publications

GO - Molecular functioni

  • transcription corepressor activity Source: PomBase

GO - Biological processi

  • cellular response to nitrogen starvation Source: PomBase
  • chromatin modification Source: UniProtKB-KW
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • DNA replication-independent nucleosome assembly Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hir1
Alternative name(s):
Histone transcription regulator 1 homolog
Gene namesi
Name:hip1
Synonyms:hir1
ORF Names:SPBC31F10.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.13c.
PomBaseiSPBC31F10.13c. hip1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: GOC
  • chromosome, centromeric region Source: GOC
  • cytosol Source: PomBase
  • HIR complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Protein hir1PRO_0000051023Add
BLAST

Proteomic databases

MaxQBiP87314.

Interactioni

Subunit structurei

Interacts with his3 and slm9.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
hip3P873152EBI-1556094,EBI-1556159
slm9O743094EBI-1556094,EBI-1556117

Protein-protein interaction databases

BioGridi276752. 296 interactions.
IntActiP87314. 2 interactions.
MINTiMINT-4693166.

Structurei

Secondary structure

1
932
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi477 – 4793Combined sources
Beta strandi485 – 4873Combined sources
Beta strandi490 – 4934Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z34X-ray2.40C/D469-497[»]
ProteinModelPortaliP87314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati16 – 5540WD 1Add
BLAST
Repeati72 – 11140WD 2Add
BLAST
Repeati132 – 17140WD 3Add
BLAST
Repeati174 – 21340WD 4Add
BLAST
Repeati222 – 26544WD 5Add
BLAST
Repeati268 – 31649WD 6Add
BLAST
Repeati320 – 36142WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000208205.
InParanoidiP87314.
KOiK11293.
OMAiMESAPIS.
OrthoDBiEOG7NCVC9.
PhylomeDBiP87314.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR011659. PD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 2 hits.
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF07676. PD40. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKKIPWLG HFDDRGHRLS IFSIHIHPDG SRIATGGLDG TIRIWSTEAI
60 70 80 90 100
NRENENENEN EDLPKQLCCM STHTGTVTSV RFSPNGQYLA SGSDDRVVII
110 120 130 140 150
WHKEEAIPGL GSTFGSGEKH TENWRSYRRL LGHDNDIQDL CWSYDSQLVV
160 170 180 190 200
SVGLDSSIIV WNGTTFERLK RIEAHQSHVK GITFDPAGKY FATESDDRTI
210 220 230 240 250
KVWRVSDFSI EKTITGPFNN SPLSTYFRRP SWSPDGKHIA APNAMNGPVS
260 270 280 290 300
CVSIIERGTW TSEINLIGHE GPVEVTAFNP KLFRDKNDKL VCILACGGQD
310 320 330 340 350
RSLSIWSSAL PRPLLSCQNV FQKSIGDVCW SPDGLSLFLC SYDGNVLVCT
360 370 380 390 400
FEKEEFGDMV SDEEISKALA KYGHGRHGIV LPESAKQLEL EETAYAILKK
410 420 430 440 450
PSSLSTTDPT LVPQSSSTPK SAQKTPQKLP AFLPNRLTAE TVDTNKLTAS
460 470 480 490 500
KEQIASPKRP GPSDNGNEIP TKFVQKVTIT KEGKKRVAPQ LLTTLSATPS
510 520 530 540 550
TSRLASTQLQ HTGSSQLPPQ QFSQPINSLP KGGVPILIVG NKTKVNHEND
560 570 580 590 600
ESDQALQEEK IEEGLLKNYY SSLIDSSTSI SNINFEAPRY KTNIVHSLNN
610 620 630 640 650
EQKYVLEVKN GTSEKNPTRI VALENGNTKW MDYLPRPVIL VTGSIHFWSI
660 670 680 690 700
ACDDGSLHLY SLTGSRLLPP IMIESKASFL HCNNAYLLCI SSSGMVYAWN
710 720 730 740 750
VVNKTALFTA NSLAPILSRV SNNVTIENNS TDIPHVVIAS ISKEGVPSVT
760 770 780 790 800
LSTGETYVYS STMLCWQRIT EPWWAIGSRE WDSSGLLQSN TQTESQPLKI
810 820 830 840 850
YEHRTNNVLM DSGRGKLLQK MVADAITEEG YDDFETIVTI NHLENKIASA
860 870 880 890 900
RLLKLDDEFL VTSEVYVRLL MHHGLWQKLE EFLGELRTQT KCSIKLSGRE
910 920 930
VVAKMLVVLR QAVQTDNEFD RANKLIEKYA ST
Length:932
Mass (Da):103,686
Last modified:July 1, 1997 - v1
Checksum:i09D527CDB9003D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10089.1.
AB027992 Genomic DNA. Translation: BAA87296.1.
PIRiT40216.
RefSeqiNP_596575.1. NM_001022496.2.

Genome annotation databases

EnsemblFungiiSPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c.
GeneIDi2540219.
KEGGispo:SPBC31F10.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10089.1.
AB027992 Genomic DNA. Translation: BAA87296.1.
PIRiT40216.
RefSeqiNP_596575.1. NM_001022496.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z34X-ray2.40C/D469-497[»]
ProteinModelPortaliP87314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276752. 296 interactions.
IntActiP87314. 2 interactions.
MINTiMINT-4693166.

Proteomic databases

MaxQBiP87314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c.
GeneIDi2540219.
KEGGispo:SPBC31F10.13c.

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.13c.
PomBaseiSPBC31F10.13c. hip1.

Phylogenomic databases

HOGENOMiHOG000208205.
InParanoidiP87314.
KOiK11293.
OMAiMESAPIS.
OrthoDBiEOG7NCVC9.
PhylomeDBiP87314.

Miscellaneous databases

PROiP87314.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR011659. PD40.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 2 hits.
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF07676. PD40. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 758-920, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  3. "The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres."
    Blackwell C., Martin K.A., Greenall A., Pidoux A., Allshire R.C., Whitehall S.K.
    Mol. Cell. Biol. 24:4309-4320(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLM9, SUBCELLULAR LOCATION.
  4. "Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation."
    Greenall A., Williams E.S., Martin K.A., Palmer J.M., Gray J., Liu C., Whitehall S.K.
    J. Biol. Chem. 281:8732-8739(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HIP3.
  5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHIR1_SCHPO
AccessioniPrimary (citable) accession number: P87314
Secondary accession number(s): Q9US78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.