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Protein

Protein hir1

Gene

hip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.2 Publications

GO - Molecular functioni

  • nucleosome binding Source: GO_Central
  • transcription corepressor activity Source: PomBase

GO - Biological processi

  • chromatin organization Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • DNA replication-independent nucleosome assembly Source: GO_Central
  • heterochromatin organization involved in chromatin silencing Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • nucleosome organization Source: PomBase
  • regulation of chromatin silencing Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hir1
Alternative name(s):
Histone transcription regulator 1 homolog
Gene namesi
Name:hip1
Synonyms:hir1
ORF Names:SPBC31F10.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.13c
PomBaseiSPBC31F10.13c hip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510231 – 932Protein hir1Add BLAST932

Proteomic databases

MaxQBiP87314
PaxDbiP87314
PRIDEiP87314

PTM databases

iPTMnetiP87314

Interactioni

Subunit structurei

Interacts with his3 and slm9.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276752, 296 interactors
IntActiP87314, 2 interactors
STRINGi4896.SPBC31F10.13c.1

Structurei

Secondary structure

1932
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi477 – 479Combined sources3
Beta strandi485 – 487Combined sources3
Beta strandi490 – 493Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z34X-ray2.40C/D469-497[»]
ProteinModelPortaliP87314
SMRiP87314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 55WD 1Add BLAST40
Repeati72 – 111WD 2Add BLAST40
Repeati132 – 171WD 3Add BLAST40
Repeati174 – 213WD 4Add BLAST40
Repeati222 – 265WD 5Add BLAST44
Repeati268 – 316WD 6Add BLAST49
Repeati320 – 361WD 7Add BLAST42

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000208205
InParanoidiP87314
KOiK11293
OMAiLLGPVHY
OrthoDBiEOG092C0UNU
PhylomeDBiP87314

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR019015 HIRA_B_motif
IPR011659 PD40
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13831 PTHR13831, 1 hit
PfamiView protein in Pfam
PF07569 Hira, 1 hit
PF09453 HIRA_B, 1 hit
PF07676 PD40, 1 hit
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P87314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKKIPWLG HFDDRGHRLS IFSIHIHPDG SRIATGGLDG TIRIWSTEAI
60 70 80 90 100
NRENENENEN EDLPKQLCCM STHTGTVTSV RFSPNGQYLA SGSDDRVVII
110 120 130 140 150
WHKEEAIPGL GSTFGSGEKH TENWRSYRRL LGHDNDIQDL CWSYDSQLVV
160 170 180 190 200
SVGLDSSIIV WNGTTFERLK RIEAHQSHVK GITFDPAGKY FATESDDRTI
210 220 230 240 250
KVWRVSDFSI EKTITGPFNN SPLSTYFRRP SWSPDGKHIA APNAMNGPVS
260 270 280 290 300
CVSIIERGTW TSEINLIGHE GPVEVTAFNP KLFRDKNDKL VCILACGGQD
310 320 330 340 350
RSLSIWSSAL PRPLLSCQNV FQKSIGDVCW SPDGLSLFLC SYDGNVLVCT
360 370 380 390 400
FEKEEFGDMV SDEEISKALA KYGHGRHGIV LPESAKQLEL EETAYAILKK
410 420 430 440 450
PSSLSTTDPT LVPQSSSTPK SAQKTPQKLP AFLPNRLTAE TVDTNKLTAS
460 470 480 490 500
KEQIASPKRP GPSDNGNEIP TKFVQKVTIT KEGKKRVAPQ LLTTLSATPS
510 520 530 540 550
TSRLASTQLQ HTGSSQLPPQ QFSQPINSLP KGGVPILIVG NKTKVNHEND
560 570 580 590 600
ESDQALQEEK IEEGLLKNYY SSLIDSSTSI SNINFEAPRY KTNIVHSLNN
610 620 630 640 650
EQKYVLEVKN GTSEKNPTRI VALENGNTKW MDYLPRPVIL VTGSIHFWSI
660 670 680 690 700
ACDDGSLHLY SLTGSRLLPP IMIESKASFL HCNNAYLLCI SSSGMVYAWN
710 720 730 740 750
VVNKTALFTA NSLAPILSRV SNNVTIENNS TDIPHVVIAS ISKEGVPSVT
760 770 780 790 800
LSTGETYVYS STMLCWQRIT EPWWAIGSRE WDSSGLLQSN TQTESQPLKI
810 820 830 840 850
YEHRTNNVLM DSGRGKLLQK MVADAITEEG YDDFETIVTI NHLENKIASA
860 870 880 890 900
RLLKLDDEFL VTSEVYVRLL MHHGLWQKLE EFLGELRTQT KCSIKLSGRE
910 920 930
VVAKMLVVLR QAVQTDNEFD RANKLIEKYA ST
Length:932
Mass (Da):103,686
Last modified:July 1, 1997 - v1
Checksum:i09D527CDB9003D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10089.1
AB027992 Genomic DNA Translation: BAA87296.1
PIRiT40216
RefSeqiNP_596575.1, NM_001022496.2

Genome annotation databases

EnsemblFungiiSPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c
GeneIDi2540219
KEGGispo:SPBC31F10.13c

Similar proteinsi

Entry informationi

Entry nameiHIR1_SCHPO
AccessioniPrimary (citable) accession number: P87314
Secondary accession number(s): Q9US78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health