Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mediator of RNA polymerase II transcription subunit 17

Gene

med17

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 17
Alternative name(s):
Mediator complex subunit 17
Suppressor of RNA polymerase B 4 homolog
Gene namesi
Name:med17
Synonyms:srb4
ORF Names:SPBC31F10.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.04c.
PomBaseiSPBC31F10.04c.

Subcellular locationi

GO - Cellular componenti

  • mediator complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963651 – 545Mediator of RNA polymerase II transcription subunit 17Add BLAST545

Proteomic databases

MaxQBiP87306.
PRIDEiP87306.

Interactioni

Subunit structurei

Component of the Mediator complex. Interacts with med18, prk1 and rbp1.2 Publications

Protein-protein interaction databases

BioGridi276825. 4 interactors.
DIPiDIP-38758N.
IntActiP87306. 6 interactors.
MINTiMINT-4693102.

Structurei

Secondary structure

1545
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi101 – 130Combined sources30
Turni131 – 133Combined sources3
Helixi136 – 140Combined sources5
Helixi143 – 148Combined sources6
Beta strandi154 – 158Combined sources5
Helixi168 – 213Combined sources46
Beta strandi218 – 220Combined sources3
Turni222 – 224Combined sources3
Beta strandi226 – 229Combined sources4
Beta strandi242 – 246Combined sources5
Turni248 – 250Combined sources3
Beta strandi253 – 256Combined sources4
Beta strandi265 – 271Combined sources7
Beta strandi277 – 282Combined sources6
Helixi293 – 320Combined sources28
Beta strandi330 – 336Combined sources7
Beta strandi342 – 348Combined sources7
Helixi374 – 407Combined sources34
Helixi425 – 447Combined sources23
Beta strandi451 – 457Combined sources7
Helixi459 – 461Combined sources3
Helixi466 – 472Combined sources7
Beta strandi473 – 475Combined sources3
Beta strandi479 – 486Combined sources8
Beta strandi493 – 497Combined sources5
Beta strandi509 – 512Combined sources4
Beta strandi517 – 522Combined sources6
Helixi523 – 534Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H63X-ray3.40Q78-545[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 17 family.Curated

Phylogenomic databases

InParanoidiP87306.
KOiK15134.
OrthoDBiEOG092C3XD1.

Family and domain databases

InterProiIPR019313. Mediator_Med17.
[Graphical view]
PfamiPF10156. Med17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEANKDAD ISSLSLSLDP EIIGGQNNFL ENNLQQIFQK IIQERGPFRD
60 70 80 90 100
LKEEDLQKEL QKESIKDESS AKSSETENVL EFATLDSKRN VNDTEVESMD
110 120 130 140 150
SQAYKKELIE QIMIAQTECS LALDMTSLLL SKFKENSIET ISPFLKSTVP
160 170 180 190 200
PSSLQFSRSQ PPESKESDAT LAKCWKEKSL TSSCKFLFEA KERLTSVVET
210 220 230 240 250
EHEYYTELVK VKEASWPLFN SQGSNHLSVQ YSCLGGISLG LGLIRMKPES
260 270 280 290 300
KSFEVQSSLL YSQAALKISI LNKDRDEIGS STWSWPSQNC NSVLLKDIYK
310 320 330 340 350
LQEILFEMDI WNSLLQEAQS CGNQGVNFTG DEILVPISDD HVVRITLETS
360 370 380 390 400
SKNTESGFTE DKKSNEDTST NFVTIKQEKE LLKCLCDTLN AIAHILFLKH
410 420 430 440 450
CRKSDRRSQQ PELYMAIDAN APLILRPLIF YYNLNQESLE FQRWLKQRDI
460 470 480 490 500
SFKFMPNYPW EKAKDFLELE NSLSINRLSI SWRIMVSNFE PAIFIQHTPT
510 520 530 540
LHGTDKSVWR CKDQYSSNQF SSLKNVCQYI EHHINSLSRR SKKTE
Length:545
Mass (Da):62,480
Last modified:July 1, 1997 - v1
Checksum:i5BC16074D9D0A05B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10081.1.
PIRiT40207.
RefSeqiNP_596566.1. NM_001022487.2.

Genome annotation databases

EnsemblFungiiSPBC31F10.04c.1; SPBC31F10.04c.1:pep; SPBC31F10.04c.
GeneIDi2540294.
KEGGispo:SPBC31F10.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10081.1.
PIRiT40207.
RefSeqiNP_596566.1. NM_001022487.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H63X-ray3.40Q78-545[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276825. 4 interactors.
DIPiDIP-38758N.
IntActiP87306. 6 interactors.
MINTiMINT-4693102.

Proteomic databases

MaxQBiP87306.
PRIDEiP87306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC31F10.04c.1; SPBC31F10.04c.1:pep; SPBC31F10.04c.
GeneIDi2540294.
KEGGispo:SPBC31F10.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.04c.
PomBaseiSPBC31F10.04c.

Phylogenomic databases

InParanoidiP87306.
KOiK15134.
OrthoDBiEOG092C3XD1.

Miscellaneous databases

PROiP87306.

Family and domain databases

InterProiIPR019313. Mediator_Med17.
[Graphical view]
PfamiPF10156. Med17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMED17_SCHPO
AccessioniPrimary (citable) accession number: P87306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.