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Protein

RNA polymerase II transcription factor B subunit 2

Gene

tfb2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2
Alternative name(s):
RNA polymerase II transcription factor B 52 kDa subunit
RNA polymerase II transcription factor B p52 subunit
Gene namesi
Name:tfb2
ORF Names:SPBC13G1.13, SPBC31F10.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC13G1.13.
PomBaseiSPBC13G1.13. tfb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001192661 – 447RNA polymerase II transcription factor B subunit 2Add BLAST447

Proteomic databases

MaxQBiP87303.
PRIDEiP87303.

Interactioni

Subunit structurei

One of the nine subunits forming the core-TFIIH basal transcription factor.1 Publication

Protein-protein interaction databases

BioGridi276340. 5 interactors.
IntActiP87303. 4 interactors.
STRINGi4896.SPBC13G1.13.1.

Structurei

3D structure databases

ProteinModelPortaliP87303.
SMRiP87303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.Curated

Phylogenomic databases

HOGENOMiHOG000170529.
InParanoidiP87303.
KOiK03144.
OMAiYLEQYAH.
OrthoDBiEOG092C3703.
PhylomeDBiP87303.

Family and domain databases

InterProiView protein in InterPro
IPR004598. TFIIH_p52/Tfb2.
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiView protein in Pfam
PF03849. Tfb2. 1 hit.
TIGRFAMsiTIGR00625. tfb2. 1 hit.

Sequencei

Sequence statusi: Complete.

P87303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAEFKSSIN DFLEQLPNHA RLYQKPAACL AVFRLLPILA RQYVMSMLFN
60 70 80 90 100
PMPVALSDFD LWIKLSSKVY QSESFNKLVR MHIFQFDGQY ITLNSEFRKQ
110 120 130 140 150
FITALTGGGN HNSFGVPCTD EDKHLVTVDF LDAYAKETWE TILHFMVGTP
160 170 180 190 200
EAKFPGEGVL SLLKRGGLMS GPKNQLRITR AGFQFLLQDI NAQIWTLLLD
210 220 230 240 250
YLKLSEDTHM DPVQVLHFLF MLGSLDLGRA YSVDFLTDTQ QIMLEDLREY
260 270 280 290 300
GLVYQRKITS KRFYPTRLAT GLTTDYRSLH GKQSENDDDK GFIIVETNYR
310 320 330 340 350
LYAYTSSPLQ IAIIGLFANL RARFSNLVVG VITRDSIRRA LMNGIAAEQI
360 370 380 390 400
ITYLTTHAHP QMRSNVPLLP PTLVDQIYLW ELEKNRLRAT PGILFRDFLT
410 420 430 440
DSGFDQAVEY AKELGVLVWD SSLKRMFFIT TTGAQPMIAY LKRRAVK
Length:447
Mass (Da):51,192
Last modified:May 1, 1999 - v2
Checksum:i2090A6187E393F40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA18666.1.
PIRiT39414.
RefSeqiNP_596563.1. NM_001022484.2.

Genome annotation databases

EnsemblFungiiSPBC13G1.13.1; SPBC13G1.13.1:pep; SPBC13G1.13.
GeneIDi2539790.
KEGGispo:SPBC13G1.13.

Similar proteinsi

Entry informationi

Entry nameiTFB2_SCHPO
AccessioniPrimary (citable) accession number: P87303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families