P87284 (PMP3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasma membrane proteolipid 3

Gene names

Name:	PMP3
Synonyms:	SNA1
Ordered Locus Names:	YDR276C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the regulation of membrane potential. Could mediate a proton leak.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential Ref.1.
Sequence similarities	Belongs to the UPF0057 (PMP3) family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from mutant phenotype Ref.1. Source: SGD regulation of membrane potential Inferred from mutant phenotype Ref.1. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 55	55	Plasma membrane proteolipid 3		PRO_0000193987
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	31 – 51	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P87284 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 05FDED31A1414AC0	FASTA	55	6,138
	10 20 30 40 50 MDSAKIINII LSLFLPPVAV FLARGWGTDC IVDIILTILA WFPGMLYALY IVLQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane." Navarre C., Goffeau A. EMBO J. 19:2515-2524(2000) [PubMed: 10835350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, CHARACTERIZATION, SUBCELLULAR LOCATION. Strain: ATCC 201238 / W303-1B.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P. Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X91499 Genomic DNA. Translation: CAA62799.1. U51030 Genomic DNA. Translation: AAB64465.1. AY557718 Genomic DNA. Translation: AAS56044.1. BK006938 Genomic DNA. Translation: DAA12117.1.
PIR	S70224.
RefSeq	NP_010562.1. NM_001180584.1.
3D structure databases
ProteinModelPortal	P87284.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7280N.
IntAct	P87284. 145 interactions.
MINT	MINT-1354397.
STRING	P87284.
Protein family/group databases
TCDB	9.B.12.1.2. (Salt or low Temperature) stress-induced hydrophobic peptide (SHP) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YDR276C; YDR276C; YDR276C.
GeneID	851869.
KEGG	sce:YDR276C.
NMPDR	fig|4932.3.peg.1324.
Organism-specific databases
CYGD	YDR276c.
SGD	S000002684. PMP3.
Phylogenomic databases
eggNOG	fuNOG13645.
GeneTree	EFGT00050000003695.
HOGENOM	HBG741476.
OMA	ILTILAW.
OrthoDB	EOG4DJP6C.
Gene expression databases
ArrayExpress	P87284.
Genevestigator	P87284.
GermOnline	YDR276C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000612. PMP3. [Graphical view]
PANTHER	PTHR21659. UPF0057. 1 hit.
Pfam	PF01679. Pmp3. 1 hit. [Graphical view]
PROSITE	PS01309. UPF0057. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	969818.

Entry information

Entry name

PMP3_YEAST

Accession

Primary (citable) accession number: P87284
Secondary accession number(s): D6VSQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program