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Protein

Plasma membrane proteolipid 3

Gene

PMP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of membrane potential. Could mediate a proton leak.

GO - Molecular functioni

  • phosphatidic acid binding Source: SGD
  • phosphatidylinositol-3,5-bisphosphate binding Source: SGD
  • phosphatidylinositol-3-phosphate binding Source: SGD
  • sphingolipid binding Source: SGD

GO - Biological processi

  • cation transport Source: SGD
  • cellular response to drug Source: SGD
  • regulation of membrane potential Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29842-MONOMER.

Protein family/group databases

TCDBi9.B.12.1.2. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane proteolipid 3
Gene namesi
Name:PMP3
Synonyms:SNA1
Ordered Locus Names:YDR276C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR276C.
SGDiS000002684. PMP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5555Plasma membrane proteolipid 3PRO_0000193987Add
BLAST

Proteomic databases

TopDownProteomicsiP87284.

Interactioni

Protein-protein interaction databases

BioGridi32329. 196 interactions.
DIPiDIP-7280N.
IntActiP87284. 11 interactions.
MINTiMINT-1354397.

Structurei

3D structure databases

ProteinModelPortaliP87284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0057 (PMP3) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000274029.
InParanoidiP87284.
OMAiSTHFWIN.
OrthoDBiEOG70CRMF.

Family and domain databases

InterProiIPR000612. PMP3.
[Graphical view]
PANTHERiPTHR21659. PTHR21659. 1 hit.
PfamiPF01679. Pmp3. 1 hit.
[Graphical view]
PROSITEiPS01309. UPF0057. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAKIINII LSLFLPPVAV FLARGWGTDC IVDIILTILA WFPGMLYALY

IVLQD
Length:55
Mass (Da):6,138
Last modified:July 1, 1997 - v1
Checksum:i05FDED31A1414AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91499 Genomic DNA. Translation: CAA62799.1.
U51030 Genomic DNA. Translation: AAB64465.1.
AY557718 Genomic DNA. Translation: AAS56044.1.
BK006938 Genomic DNA. Translation: DAA12117.1.
PIRiS70224.
RefSeqiNP_010562.1. NM_001180584.1.

Genome annotation databases

EnsemblFungiiYDR276C; YDR276C; YDR276C.
GeneIDi851869.
KEGGisce:YDR276C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91499 Genomic DNA. Translation: CAA62799.1.
U51030 Genomic DNA. Translation: AAB64465.1.
AY557718 Genomic DNA. Translation: AAS56044.1.
BK006938 Genomic DNA. Translation: DAA12117.1.
PIRiS70224.
RefSeqiNP_010562.1. NM_001180584.1.

3D structure databases

ProteinModelPortaliP87284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32329. 196 interactions.
DIPiDIP-7280N.
IntActiP87284. 11 interactions.
MINTiMINT-1354397.

Protein family/group databases

TCDBi9.B.12.1.2. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

Proteomic databases

TopDownProteomicsiP87284.

Protocols and materials databases

DNASUi851869.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR276C; YDR276C; YDR276C.
GeneIDi851869.
KEGGisce:YDR276C.

Organism-specific databases

EuPathDBiFungiDB:YDR276C.
SGDiS000002684. PMP3.

Phylogenomic databases

HOGENOMiHOG000274029.
InParanoidiP87284.
OMAiSTHFWIN.
OrthoDBiEOG70CRMF.

Enzyme and pathway databases

BioCyciYEAST:G3O-29842-MONOMER.

Miscellaneous databases

PROiP87284.

Family and domain databases

InterProiIPR000612. PMP3.
[Graphical view]
PANTHERiPTHR21659. PTHR21659. 1 hit.
PfamiPF01679. Pmp3. 1 hit.
[Graphical view]
PROSITEiPS01309. UPF0057. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane."
    Navarre C., Goffeau A.
    EMBO J. 19:2515-2524(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25, CHARACTERIZATION, SUBCELLULAR LOCATION.
    Strain: ATCC 201238 / W303-1B.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiPMP3_YEAST
AccessioniPrimary (citable) accession number: P87284
Secondary accession number(s): D6VSQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.