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Protein

Plasma membrane proteolipid 3

Gene

PMP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of membrane potential. Could mediate a proton leak.

GO - Molecular functioni

  • phosphatidic acid binding Source: SGD
  • phosphatidylinositol-3,5-bisphosphate binding Source: SGD
  • phosphatidylinositol-3-phosphate binding Source: SGD
  • sphingolipid binding Source: SGD

GO - Biological processi

  • cation transport Source: SGD
  • cellular response to drug Source: SGD
  • regulation of membrane potential Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29842-MONOMER

Protein family/group databases

TCDBi9.B.12.1.2 the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane proteolipid 3
Gene namesi
Name:PMP3
Synonyms:SNA1
Ordered Locus Names:YDR276C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR276C
SGDiS000002684 PMP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001939871 – 55Plasma membrane proteolipid 3Add BLAST55

Proteomic databases

PaxDbiP87284
PRIDEiP87284
TopDownProteomicsiP87284

Interactioni

Protein-protein interaction databases

BioGridi32329, 511 interactors
DIPiDIP-7280N
IntActiP87284, 16 interactors
MINTiP87284
STRINGi4932.YDR276C

Structurei

3D structure databases

ProteinModelPortaliP87284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0057 (PMP3) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000274029
InParanoidiP87284
OMAiWFPGILH
OrthoDBiEOG092C5YWZ

Family and domain databases

InterProiView protein in InterPro
IPR000612 PMP3
PANTHERiPTHR21659 PTHR21659, 1 hit
PfamiView protein in Pfam
PF01679 Pmp3, 1 hit
PROSITEiView protein in PROSITE
PS01309 UPF0057, 1 hit

Sequencei

Sequence statusi: Complete.

P87284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAKIINII LSLFLPPVAV FLARGWGTDC IVDIILTILA WFPGMLYALY

IVLQD
Length:55
Mass (Da):6,138
Last modified:July 1, 1997 - v1
Checksum:i05FDED31A1414AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91499 Genomic DNA Translation: CAA62799.1
U51030 Genomic DNA Translation: AAB64465.1
AY557718 Genomic DNA Translation: AAS56044.1
BK006938 Genomic DNA Translation: DAA12117.1
PIRiS70224
RefSeqiNP_010562.1, NM_001180584.1

Genome annotation databases

EnsemblFungiiYDR276C; YDR276C; YDR276C
GeneIDi851869
KEGGisce:YDR276C

Similar proteinsi

Entry informationi

Entry nameiPMP3_YEAST
AccessioniPrimary (citable) accession number: P87284
Secondary accession number(s): D6VSQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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