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Protein

60S ribosomal protein L34-A

Gene

RPL34A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. ribosome biogenesis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30350-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L34-A
Gene namesi
Name:RPL34A
Ordered Locus Names:YER056C-A
ORF Names:YER056BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER056c-a.
SGDiS000002135. RPL34A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. preribosome, large subunit precursor Source: SGD
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12112160S ribosomal protein L34-APRO_0000131845Add
BLAST

Proteomic databases

MaxQBiP87262.
PaxDbiP87262.
PRIDEiP87262.

Expressioni

Gene expression databases

GenevestigatoriP87262.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi36797. 30 interactions.
IntActiP87262. 13 interactions.
MINTiMINT-8285618.
STRINGi4932.YER056C-A.

Structurei

Secondary structure

1
121
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 103Combined sources
Helixi16 – 183Combined sources
Beta strandi19 – 246Combined sources
Turni26 – 283Combined sources
Beta strandi30 – 356Combined sources
Turni45 – 473Combined sources
Beta strandi52 – 543Combined sources
Helixi59 – 646Combined sources
Helixi67 – 704Combined sources
Turni75 – 795Combined sources
Helixi83 – 11129Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10h1-121[»]
1VWUelectron microscopy6.10h1-121[»]
1VXVelectron microscopy6.20h1-121[»]
1VXYelectron microscopy6.30h1-121[»]
3IZSelectron microscopy-i1-118[»]
3J65electron microscopy8.70f1-121[»]
3U5EX-ray3.00g1-121[»]
3U5IX-ray3.00g1-121[»]
4B6Aelectron microscopy8.10g1-121[»]
4BYNelectron microscopy4.30g2-121[»]
4BYUelectron microscopy6.60g2-121[»]
4CUWelectron microscopy3.70g1-121[»]
4UJHX-ray3.20T2-120[»]
4UJJX-ray3.20Y2-120[»]
4UJMX-ray3.00T2-121[»]
4UJOX-ray3.00Y2-121[»]
4UJRX-ray2.80T2-121[»]
4UJTX-ray2.80Y2-121[»]
4UJWX-ray3.10T2-120[»]
4UJYX-ray3.10X2-120[»]
4UK1X-ray3.00T2-121[»]
4UK3X-ray3.00Y2-121[»]
4UK6X-ray3.20T2-121[»]
4UK8X-ray3.20Y2-121[»]
4UKBX-ray2.90T2-121[»]
4UKEX-ray2.90Y2-121[»]
4UKHX-ray3.45T2-120[»]
4UKJX-ray3.45X2-120[»]
4UKMX-ray3.20T2-120[»]
4UKOX-ray3.20X2-120[»]
4UKRX-ray3.30T2-121[»]
4UKTX-ray3.30Y2-121[»]
4UKWX-ray3.10T2-121[»]
4UKYX-ray3.10Y2-121[»]
4UL1X-ray3.60T2-109[»]
4UL3X-ray3.60Y2-109[»]
4UL6X-ray3.00T2-120[»]
4UL8X-ray3.00Y2-120[»]
4ULBX-ray3.00T2-109[»]
4ULDX-ray3.00Y2-109[»]
4ULGX-ray3.20T2-120[»]
4ULIX-ray3.20Y2-120[»]
4ULMX-ray3.10T2-109[»]
4ULOX-ray3.10Y2-109[»]
4ULRX-ray3.20T2-120[»]
4ULTX-ray3.20X2-120[»]
4V7Felectron microscopy8.70f1-121[»]
4V8Telectron microscopy8.10g1-121[»]
ProteinModelPortaliP87262.
SMRiP87262. Positions 2-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L34e family.Curated

Phylogenomic databases

eggNOGiCOG2174.
GeneTreeiENSGT00390000008294.
HOGENOMiHOG000216922.
InParanoidiP87262.
KOiK02915.
OMAiKAPESAC.
OrthoDBiEOG76TB4F.

Family and domain databases

InterProiIPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
[Graphical view]
PANTHERiPTHR10759. PTHR10759. 1 hit.
PfamiPF01199. Ribosomal_L34e. 1 hit.
[Graphical view]
PRINTSiPR01250. RIBOSOMALL34.
PROSITEiPS01145. RIBOSOMAL_L34E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87262-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQRVTFRRR NPYNTRSNKI KVVKTPGGIL RAQHVKKLAT RPKCGDCGSA
60 70 80 90 100
LQGISTLRPR QYATVSKTHK TVSRAYGGSR CANCVKERII RAFLIEEQKI
110 120
VKKVVKEQTE AAKKSEKKAK K
Length:121
Mass (Da):13,639
Last modified:July 1, 1997 - v1
Checksum:iF3315816CD85ACEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64609.1.
BK006939 Genomic DNA. Translation: DAA07714.1.
PIRiS53549.
RefSeqiNP_010977.2. NM_001180036.1.

Genome annotation databases

EnsemblFungiiYER056C-A; YER056C-A; YER056C-A.
GeneIDi856784.
KEGGisce:YER056C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18813 Genomic DNA. Translation: AAB64609.1.
BK006939 Genomic DNA. Translation: DAA07714.1.
PIRiS53549.
RefSeqiNP_010977.2. NM_001180036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10h1-121[»]
1VWUelectron microscopy6.10h1-121[»]
1VXVelectron microscopy6.20h1-121[»]
1VXYelectron microscopy6.30h1-121[»]
3IZSelectron microscopy-i1-118[»]
3J65electron microscopy8.70f1-121[»]
3U5EX-ray3.00g1-121[»]
3U5IX-ray3.00g1-121[»]
4B6Aelectron microscopy8.10g1-121[»]
4BYNelectron microscopy4.30g2-121[»]
4BYUelectron microscopy6.60g2-121[»]
4CUWelectron microscopy3.70g1-121[»]
4UJHX-ray3.20T2-120[»]
4UJJX-ray3.20Y2-120[»]
4UJMX-ray3.00T2-121[»]
4UJOX-ray3.00Y2-121[»]
4UJRX-ray2.80T2-121[»]
4UJTX-ray2.80Y2-121[»]
4UJWX-ray3.10T2-120[»]
4UJYX-ray3.10X2-120[»]
4UK1X-ray3.00T2-121[»]
4UK3X-ray3.00Y2-121[»]
4UK6X-ray3.20T2-121[»]
4UK8X-ray3.20Y2-121[»]
4UKBX-ray2.90T2-121[»]
4UKEX-ray2.90Y2-121[»]
4UKHX-ray3.45T2-120[»]
4UKJX-ray3.45X2-120[»]
4UKMX-ray3.20T2-120[»]
4UKOX-ray3.20X2-120[»]
4UKRX-ray3.30T2-121[»]
4UKTX-ray3.30Y2-121[»]
4UKWX-ray3.10T2-121[»]
4UKYX-ray3.10Y2-121[»]
4UL1X-ray3.60T2-109[»]
4UL3X-ray3.60Y2-109[»]
4UL6X-ray3.00T2-120[»]
4UL8X-ray3.00Y2-120[»]
4ULBX-ray3.00T2-109[»]
4ULDX-ray3.00Y2-109[»]
4ULGX-ray3.20T2-120[»]
4ULIX-ray3.20Y2-120[»]
4ULMX-ray3.10T2-109[»]
4ULOX-ray3.10Y2-109[»]
4ULRX-ray3.20T2-120[»]
4ULTX-ray3.20X2-120[»]
4V7Felectron microscopy8.70f1-121[»]
4V8Telectron microscopy8.10g1-121[»]
ProteinModelPortaliP87262.
SMRiP87262. Positions 2-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36797. 30 interactions.
IntActiP87262. 13 interactions.
MINTiMINT-8285618.
STRINGi4932.YER056C-A.

Proteomic databases

MaxQBiP87262.
PaxDbiP87262.
PRIDEiP87262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER056C-A; YER056C-A; YER056C-A.
GeneIDi856784.
KEGGisce:YER056C-A.

Organism-specific databases

CYGDiYER056c-a.
SGDiS000002135. RPL34A.

Phylogenomic databases

eggNOGiCOG2174.
GeneTreeiENSGT00390000008294.
HOGENOMiHOG000216922.
InParanoidiP87262.
KOiK02915.
OMAiKAPESAC.
OrthoDBiEOG76TB4F.

Enzyme and pathway databases

BioCyciYEAST:G3O-30350-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

NextBioi983000.

Gene expression databases

GenevestigatoriP87262.

Family and domain databases

InterProiIPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
[Graphical view]
PANTHERiPTHR10759. PTHR10759. 1 hit.
PfamiPF01199. Ribosomal_L34e. 1 hit.
[Graphical view]
PRINTSiPR01250. RIBOSOMALL34.
PROSITEiPS01145. RIBOSOMAL_L34E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL34A_YEAST
AccessioniPrimary (citable) accession number: P87262
Secondary accession number(s): D3DLW0, Q03189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 23600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L34 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.