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Protein

Protein kinase C-like

Gene

NCU06544

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei846ATPPROSITE-ProRule annotation1
Active sitei942Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri457 – 505Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri525 – 576Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52
Nucleotide bindingi823 – 831ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like (EC:2.7.11.13)
Gene namesi
ORF Names:NCU06544
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU06544

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557441 – 1142Protein kinase C-likeAdd BLAST1142

Proteomic databases

PRIDEiP87253

Structurei

3D structure databases

ProteinModelPortaliP87253
SMRiP87253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 67REM-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini149 – 226REM-1 2PROSITE-ProRule annotationAdd BLAST78
Domaini817 – 1076Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini1077 – 1142AGC-kinase C-terminalAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi670 – 679Poly-Ala10
Compositional biasi714 – 717Poly-Gln4
Compositional biasi746 – 754Poly-Gln9

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri457 – 505Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri525 – 576Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000176156
InParanoidiP87253
KOiK02677
OMAiLCKEDMW
OrthoDBiEOG092C0HH3

Family and domain databases

CDDicd00029 C1, 2 hits
cd08689 C2_fungal_Pkc1p, 1 hit
cd11620 HR1_PKC-like_2_fungi, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR037778 C2_fungal_PKC
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR037312 PKC-like_HR1
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF02185 HR1, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00742 Hr1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51860 REM_1, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P87253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDEDKVHDI SKKIEREKAL INAAQAMRQQ TNNEQVRSKL DTQMREGRRN
60 70 80 90 100
LEFFEEKLRE LQMRRLGHGV DNMSLGASPM SGSHRQSVDD FEGYGAPSPP
110 120 130 140 150
PKEDVRGHSS HQSQGSGPLM PASAPYPGGP PDSNVPRARP NYTRLDLIKF
160 170 180 190 200
DTPHLGPRIQ LMLSQIQFKL NVEEQYLKGI EKMVQLYQME GDKKSKLDAA
210 220 230 240 250
AKRVESKQKI VLLKQALKRY EELHIDIDVD GPDDDSINLP ALRKPLSGTL
260 270 280 290 300
SIRILAVKDV DHAPLGRFAR SPETFIAVKA EDIVVARTKP SRNDKWEAEF
310 320 330 340 350
HTFPVDKTNE IEFTVYDKPA EHPVPIAMLW VRISDIVEEL RRKKIEAEMT
360 370 380 390 400
SAGWVSADRV GSRAPPPQFP MGAQSPQFAA PPTSPGSQEQ NTMIPPQAPP
410 420 430 440 450
PSQVVSQPVD GWFNLEPYGQ IHLSFNFIKG ARPQGMDRLG RKGAVRQRKE
460 470 480 490 500
EVHEMYGHKF VQKQFYNIMR CALCGDFLKY SAGMQCEDCK YTCHTKCYTS
510 520 530 540 550
VVTKCISKSN AETDPDEEKI NHRIPHRFIP FSNLTANWCC HCGYMLPIGS
560 570 580 590 600
KKNSRKCSEC ALTAHAQCVH LVPDFCGMSM AVANQILEGM RTQKKTHKDK
610 620 630 640 650
ASSMSERTLR PGSKTSISSG SIAQASTYSG STAYTSIASP EATEAAKLMY
660 670 680 690 700
SQTTPRPGGP DRTSTSSTTA SAAAAAAMAP KHSSQPSQAG SIPDFGGSPG
710 720 730 740 750
YGRPDSRDDE YSAQQQQGYG SPQQRKYNPA DYANIDAYSS PQARPQQQQQ
760 770 780 790 800
QQQQTPQQVS PMYQQNPQTP ISKPQPVAPS YDNQVVPSAS GVPVPTKKPL
810 820 830 840 850
PSATDPGTGM RIGLDHFNFL AVLGKGNFGK VMLAETKKSR KLYAIKVLKK
860 870 880 890 900
EFIIENDEVE SIRSEKRVFL IANRERHPFL TNLHACFQTE TRVYFVMEYI
910 920 930 940 950
SGGDLMLHIQ RGMFGTKRAQ FYAAEVCLAL KYFHENGVIY RDLKLDNILL
960 970 980 990 1000
TLDGHIKIAD YGLCKEDMWY GSTTSTFCGT PEFMAPEILL DKKYGRAVDW
1010 1020 1030 1040 1050
WAFGVLIYQM LLQQSPFRGE DEDEIYDAIL ADEPLYPIHM PRDSVSILQK
1060 1070 1080 1090 1100
LLTREPDQRL GSGPTDAQEI MSQPFFRNIN WDDIYHKRVQ PPFLPQIKSA
1110 1120 1130 1140
TDTSNFDSEF TSVTPVLTPV QSVLSQAMQE EFRGFSYTAD FE
Length:1,142
Mass (Da):127,972
Last modified:June 7, 2005 - v2
Checksum:iA7462CDFD1848DAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti914F → L in CAA72731 (Ref. 1) Curated1
Sequence conflicti1055 – 1056EP → DA in CAA72731 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12002 Genomic DNA Translation: CAA72731.1
CM002239 Genomic DNA Translation: EAA33015.1
RefSeqiXP_962251.1, XM_957158.2

Genome annotation databases

EnsemblFungiiEAA33015; EAA33015; NCU06544
GeneIDi3878409
KEGGincr:NCU06544

Similar proteinsi

Entry informationi

Entry nameiKPC1_NEUCR
AccessioniPrimary (citable) accession number: P87253
Secondary accession number(s): Q7RVG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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