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P87253 (KPC1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-like

EC=2.7.11.13
Gene names
ORF Names:NCU06544
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length1142 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Contains 1 protein kinase domain.

Contains 2 REM (Hr1) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11421142Protein kinase C-like
PRO_0000055744

Regions

Repeat5 – 7773REM 1
Repeat161 – 23676REM 2
Domain817 – 1076260Protein kinase
Domain1077 – 114266AGC-kinase C-terminal
Zinc finger457 – 50549Phorbol-ester/DAG-type 1
Zinc finger525 – 57652Phorbol-ester/DAG-type 2
Nucleotide binding823 – 8319ATP By similarity
Compositional bias670 – 67910Poly-Ala
Compositional bias714 – 7174Poly-Gln
Compositional bias746 – 7549Poly-Gln

Sites

Active site9421Proton acceptor By similarity
Binding site8461ATP By similarity

Experimental info

Sequence conflict9141F → L in CAA72731. Ref.1
Sequence conflict1055 – 10562EP → DA in CAA72731. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P87253 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: A7462CDFD1848DAD

FASTA1,142127,972
        10         20         30         40         50         60 
MNDEDKVHDI SKKIEREKAL INAAQAMRQQ TNNEQVRSKL DTQMREGRRN LEFFEEKLRE 

        70         80         90        100        110        120 
LQMRRLGHGV DNMSLGASPM SGSHRQSVDD FEGYGAPSPP PKEDVRGHSS HQSQGSGPLM 

       130        140        150        160        170        180 
PASAPYPGGP PDSNVPRARP NYTRLDLIKF DTPHLGPRIQ LMLSQIQFKL NVEEQYLKGI 

       190        200        210        220        230        240 
EKMVQLYQME GDKKSKLDAA AKRVESKQKI VLLKQALKRY EELHIDIDVD GPDDDSINLP 

       250        260        270        280        290        300 
ALRKPLSGTL SIRILAVKDV DHAPLGRFAR SPETFIAVKA EDIVVARTKP SRNDKWEAEF 

       310        320        330        340        350        360 
HTFPVDKTNE IEFTVYDKPA EHPVPIAMLW VRISDIVEEL RRKKIEAEMT SAGWVSADRV 

       370        380        390        400        410        420 
GSRAPPPQFP MGAQSPQFAA PPTSPGSQEQ NTMIPPQAPP PSQVVSQPVD GWFNLEPYGQ 

       430        440        450        460        470        480 
IHLSFNFIKG ARPQGMDRLG RKGAVRQRKE EVHEMYGHKF VQKQFYNIMR CALCGDFLKY 

       490        500        510        520        530        540 
SAGMQCEDCK YTCHTKCYTS VVTKCISKSN AETDPDEEKI NHRIPHRFIP FSNLTANWCC 

       550        560        570        580        590        600 
HCGYMLPIGS KKNSRKCSEC ALTAHAQCVH LVPDFCGMSM AVANQILEGM RTQKKTHKDK 

       610        620        630        640        650        660 
ASSMSERTLR PGSKTSISSG SIAQASTYSG STAYTSIASP EATEAAKLMY SQTTPRPGGP 

       670        680        690        700        710        720 
DRTSTSSTTA SAAAAAAMAP KHSSQPSQAG SIPDFGGSPG YGRPDSRDDE YSAQQQQGYG 

       730        740        750        760        770        780 
SPQQRKYNPA DYANIDAYSS PQARPQQQQQ QQQQTPQQVS PMYQQNPQTP ISKPQPVAPS 

       790        800        810        820        830        840 
YDNQVVPSAS GVPVPTKKPL PSATDPGTGM RIGLDHFNFL AVLGKGNFGK VMLAETKKSR 

       850        860        870        880        890        900 
KLYAIKVLKK EFIIENDEVE SIRSEKRVFL IANRERHPFL TNLHACFQTE TRVYFVMEYI 

       910        920        930        940        950        960 
SGGDLMLHIQ RGMFGTKRAQ FYAAEVCLAL KYFHENGVIY RDLKLDNILL TLDGHIKIAD 

       970        980        990       1000       1010       1020 
YGLCKEDMWY GSTTSTFCGT PEFMAPEILL DKKYGRAVDW WAFGVLIYQM LLQQSPFRGE 

      1030       1040       1050       1060       1070       1080 
DEDEIYDAIL ADEPLYPIHM PRDSVSILQK LLTREPDQRL GSGPTDAQEI MSQPFFRNIN 

      1090       1100       1110       1120       1130       1140 
WDDIYHKRVQ PPFLPQIKSA TDTSNFDSEF TSVTPVLTPV QSVLSQAMQE EFRGFSYTAD 


FE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12002 Genomic DNA. Translation: CAA72731.1.
AABX02000028 Genomic DNA. Translation: EAA33015.1.
RefSeqXP_962251.1. XM_957158.1.
UniGeneNcr.10565.

3D structure databases

ProteinModelPortalP87253.
SMRP87253. Positions 814-1140.
ModBaseSearch...

Protein-protein interaction databases

STRINGP87253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006352; EFNCRP00000006344; EFNCRG00000006341.
GeneID3878409.
KEGGncr:NCU06544.
NMPDRfig|5141.1.peg.4332.

Phylogenomic databases

eggNOGfuNOG05723.
GeneTreeEFGT00070000008712.
OMAWCCHCGY.
OrthoDBEOG4CRQ75.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
Gene3DG3DSA:1.10.287.160. HR1_rho-bd. 1 hit.
KOK02677.
PfamPF00130. C1_1. 2 hits.
PF02185. HR1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00742. Hr1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 1 hit.
SSF56112. Kinase_like. 1 hit.
SSF46585. PKN_effector. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPC1_NEUCR
AccessionPrimary (citable) accession number: P87253
Secondary accession number(s): Q7RVG4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families