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Protein

Protein kinase C-like

Gene

NCU06544

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei846 – 8461ATPPROSITE-ProRule annotation
Active sitei942 – 9421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri457 – 50549Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 57652Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi823 – 8319ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-like (EC:2.7.11.13)
Gene namesi
ORF Names:NCU06544
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU06544.

Subcellular locationi

GO - Cellular componenti

  • barrier septum Source: EnsemblFungi
  • cell division site Source: EnsemblFungi
  • cell septum Source: CACAO
  • cell tip Source: EnsemblFungi
  • intracellular Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11421142Protein kinase C-likePRO_0000055744Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP87253.
SMRiP87253. Positions 814-1140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 7773REM 1Add
BLAST
Repeati161 – 23676REM 2Add
BLAST
Domaini817 – 1076260Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini1077 – 114266AGC-kinase C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi670 – 67910Poly-Ala
Compositional biasi714 – 7174Poly-Gln
Compositional biasi746 – 7549Poly-Gln

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 REM (Hr1) repeats.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri457 – 50549Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 57652Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000176156.
InParanoidiP87253.
KOiK02677.
OMAiHAQCVHL.
OrthoDBiEOG092C0HH3.

Family and domain databases

Gene3Di1.10.287.160. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF02185. HR1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00742. Hr1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDEDKVHDI SKKIEREKAL INAAQAMRQQ TNNEQVRSKL DTQMREGRRN
60 70 80 90 100
LEFFEEKLRE LQMRRLGHGV DNMSLGASPM SGSHRQSVDD FEGYGAPSPP
110 120 130 140 150
PKEDVRGHSS HQSQGSGPLM PASAPYPGGP PDSNVPRARP NYTRLDLIKF
160 170 180 190 200
DTPHLGPRIQ LMLSQIQFKL NVEEQYLKGI EKMVQLYQME GDKKSKLDAA
210 220 230 240 250
AKRVESKQKI VLLKQALKRY EELHIDIDVD GPDDDSINLP ALRKPLSGTL
260 270 280 290 300
SIRILAVKDV DHAPLGRFAR SPETFIAVKA EDIVVARTKP SRNDKWEAEF
310 320 330 340 350
HTFPVDKTNE IEFTVYDKPA EHPVPIAMLW VRISDIVEEL RRKKIEAEMT
360 370 380 390 400
SAGWVSADRV GSRAPPPQFP MGAQSPQFAA PPTSPGSQEQ NTMIPPQAPP
410 420 430 440 450
PSQVVSQPVD GWFNLEPYGQ IHLSFNFIKG ARPQGMDRLG RKGAVRQRKE
460 470 480 490 500
EVHEMYGHKF VQKQFYNIMR CALCGDFLKY SAGMQCEDCK YTCHTKCYTS
510 520 530 540 550
VVTKCISKSN AETDPDEEKI NHRIPHRFIP FSNLTANWCC HCGYMLPIGS
560 570 580 590 600
KKNSRKCSEC ALTAHAQCVH LVPDFCGMSM AVANQILEGM RTQKKTHKDK
610 620 630 640 650
ASSMSERTLR PGSKTSISSG SIAQASTYSG STAYTSIASP EATEAAKLMY
660 670 680 690 700
SQTTPRPGGP DRTSTSSTTA SAAAAAAMAP KHSSQPSQAG SIPDFGGSPG
710 720 730 740 750
YGRPDSRDDE YSAQQQQGYG SPQQRKYNPA DYANIDAYSS PQARPQQQQQ
760 770 780 790 800
QQQQTPQQVS PMYQQNPQTP ISKPQPVAPS YDNQVVPSAS GVPVPTKKPL
810 820 830 840 850
PSATDPGTGM RIGLDHFNFL AVLGKGNFGK VMLAETKKSR KLYAIKVLKK
860 870 880 890 900
EFIIENDEVE SIRSEKRVFL IANRERHPFL TNLHACFQTE TRVYFVMEYI
910 920 930 940 950
SGGDLMLHIQ RGMFGTKRAQ FYAAEVCLAL KYFHENGVIY RDLKLDNILL
960 970 980 990 1000
TLDGHIKIAD YGLCKEDMWY GSTTSTFCGT PEFMAPEILL DKKYGRAVDW
1010 1020 1030 1040 1050
WAFGVLIYQM LLQQSPFRGE DEDEIYDAIL ADEPLYPIHM PRDSVSILQK
1060 1070 1080 1090 1100
LLTREPDQRL GSGPTDAQEI MSQPFFRNIN WDDIYHKRVQ PPFLPQIKSA
1110 1120 1130 1140
TDTSNFDSEF TSVTPVLTPV QSVLSQAMQE EFRGFSYTAD FE
Length:1,142
Mass (Da):127,972
Last modified:June 7, 2005 - v2
Checksum:iA7462CDFD1848DAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti914 – 9141F → L in CAA72731 (Ref. 1) Curated
Sequence conflicti1055 – 10562EP → DA in CAA72731 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12002 Genomic DNA. Translation: CAA72731.1.
CM002239 Genomic DNA. Translation: EAA33015.1.
RefSeqiXP_962251.1. XM_957158.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000006352; EFNCRP00000006344; EFNCRG00000006341.
GeneIDi3878409.
KEGGincr:NCU06544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12002 Genomic DNA. Translation: CAA72731.1.
CM002239 Genomic DNA. Translation: EAA33015.1.
RefSeqiXP_962251.1. XM_957158.2.

3D structure databases

ProteinModelPortaliP87253.
SMRiP87253. Positions 814-1140.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000006352; EFNCRP00000006344; EFNCRG00000006341.
GeneIDi3878409.
KEGGincr:NCU06544.

Organism-specific databases

EuPathDBiFungiDB:NCU06544.

Phylogenomic databases

HOGENOMiHOG000176156.
InParanoidiP87253.
KOiK02677.
OMAiHAQCVHL.
OrthoDBiEOG092C0HH3.

Family and domain databases

Gene3Di1.10.287.160. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF02185. HR1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00742. Hr1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPC1_NEUCR
AccessioniPrimary (citable) accession number: P87253
Secondary accession number(s): Q7RVG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.