Protein kinase C-like - Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Protein kinase C-like
EC=2.7.11.13

Gene names

ORF Names:

NCU06544

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	1142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Contains 1 protein kinase domain.

Contains 2 REM (Hr1) repeats.

Ontologies

Keywords
Domain	Repeat Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase C activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1142

1142

Protein kinase C-like

PRO_0000055744

Regions

Repeat

5 – 77

73

REM 1

Repeat

161 – 236

76

REM 2

Domain

817 – 1076

260

Protein kinase

Domain

1077 – 1142

66

AGC-kinase C-terminal

Zinc finger

457 – 505

49

Phorbol-ester/DAG-type 1

Zinc finger

525 – 576

52

Phorbol-ester/DAG-type 2

Nucleotide binding

823 – 831

9

ATP By similarity

Compositional bias

670 – 679

10

Poly-Ala

Compositional bias

714 – 717

4

Poly-Gln

Compositional bias

746 – 754

9

Poly-Gln

Sites

Active site

942

1

Proton acceptor By similarity

Binding site

846

1

ATP By similarity

Experimental info

Sequence conflict

914

1

F → L in CAA72731. Ref.1

Sequence conflict

1055 – 1056

2

EP → DA in CAA72731. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P87253 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: A7462CDFD1848DAD
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FASTA

1,142

127,972

        10         20         30         40         50         60 
MNDEDKVHDI SKKIEREKAL INAAQAMRQQ TNNEQVRSKL DTQMREGRRN LEFFEEKLRE 

        70         80         90        100        110        120 
LQMRRLGHGV DNMSLGASPM SGSHRQSVDD FEGYGAPSPP PKEDVRGHSS HQSQGSGPLM 

       130        140        150        160        170        180 
PASAPYPGGP PDSNVPRARP NYTRLDLIKF DTPHLGPRIQ LMLSQIQFKL NVEEQYLKGI 

       190        200        210        220        230        240 
EKMVQLYQME GDKKSKLDAA AKRVESKQKI VLLKQALKRY EELHIDIDVD GPDDDSINLP 

       250        260        270        280        290        300 
ALRKPLSGTL SIRILAVKDV DHAPLGRFAR SPETFIAVKA EDIVVARTKP SRNDKWEAEF 

       310        320        330        340        350        360 
HTFPVDKTNE IEFTVYDKPA EHPVPIAMLW VRISDIVEEL RRKKIEAEMT SAGWVSADRV 

       370        380        390        400        410        420 
GSRAPPPQFP MGAQSPQFAA PPTSPGSQEQ NTMIPPQAPP PSQVVSQPVD GWFNLEPYGQ 

       430        440        450        460        470        480 
IHLSFNFIKG ARPQGMDRLG RKGAVRQRKE EVHEMYGHKF VQKQFYNIMR CALCGDFLKY 

       490        500        510        520        530        540 
SAGMQCEDCK YTCHTKCYTS VVTKCISKSN AETDPDEEKI NHRIPHRFIP FSNLTANWCC 

       550        560        570        580        590        600 
HCGYMLPIGS KKNSRKCSEC ALTAHAQCVH LVPDFCGMSM AVANQILEGM RTQKKTHKDK 

       610        620        630        640        650        660 
ASSMSERTLR PGSKTSISSG SIAQASTYSG STAYTSIASP EATEAAKLMY SQTTPRPGGP 

       670        680        690        700        710        720 
DRTSTSSTTA SAAAAAAMAP KHSSQPSQAG SIPDFGGSPG YGRPDSRDDE YSAQQQQGYG 

       730        740        750        760        770        780 
SPQQRKYNPA DYANIDAYSS PQARPQQQQQ QQQQTPQQVS PMYQQNPQTP ISKPQPVAPS 

       790        800        810        820        830        840 
YDNQVVPSAS GVPVPTKKPL PSATDPGTGM RIGLDHFNFL AVLGKGNFGK VMLAETKKSR 

       850        860        870        880        890        900 
KLYAIKVLKK EFIIENDEVE SIRSEKRVFL IANRERHPFL TNLHACFQTE TRVYFVMEYI 

       910        920        930        940        950        960 
SGGDLMLHIQ RGMFGTKRAQ FYAAEVCLAL KYFHENGVIY RDLKLDNILL TLDGHIKIAD 

       970        980        990       1000       1010       1020 
YGLCKEDMWY GSTTSTFCGT PEFMAPEILL DKKYGRAVDW WAFGVLIYQM LLQQSPFRGE 

      1030       1040       1050       1060       1070       1080 
DEDEIYDAIL ADEPLYPIHM PRDSVSILQK LLTREPDQRL GSGPTDAQEI MSQPFFRNIN 

      1090       1100       1110       1120       1130       1140 
WDDIYHKRVQ PPFLPQIKSA TDTSNFDSEF TSVTPVLTPV QSVLSQAMQE EFRGFSYTAD 


FE

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a protein kinase C homologue from Neurospora crassa." Arpaia G., Macino G. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12002 Genomic DNA. Translation: CAA72731.1. AABX02000028 Genomic DNA. Translation: EAA33015.1.
RefSeq	XP_962251.1. XM_957158.1.
UniGene	Ncr.10565.
3D structure databases
ProteinModelPortal	P87253.
SMR	P87253. Positions 814-1140.
ModBase	Search...
Protein-protein interaction databases
STRING	P87253.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000006352; EFNCRP00000006344; EFNCRG00000006341.
GeneID	3878409.
KEGG	ncr:NCU06544.
NMPDR	fig\|5141.1.peg.4332.
Phylogenomic databases
eggNOG	fuNOG05723.
GeneTree	EFGT00070000008712.
OMA	WCCHCGY.
OrthoDB	EOG4CRQ75.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011072. HR1_rho-bd. IPR011009. Kinase-like_dom. IPR017892. Pkinase_C. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Gene3D	G3DSA:1.10.287.160. HR1_rho-bd. 1 hit.
KO	K02677.
Pfam	PF00130. C1_1. 2 hits. PF02185. HR1. 2 hits. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
SMART	SM00109. C1. 2 hits. SM00239. C2. 1 hit. SM00742. Hr1. 2 hits. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit. SSF46585. PKN_effector. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 2 hits. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPC1_NEUCR

Accession

Primary (citable) accession number: P87253
Secondary accession number(s): Q7RVG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 7, 2005
Last modified:	January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents