Reviewed, UniProtKB/Swiss-Prot P87248 (ATG1_COLLN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1
    Colletotrichum lindemuthianum kinase 1

Gene names

Name:	ATG1
Synonyms:	clk1

Organism

Colletotrichum lindemuthianum (Bean anthracnose fungus) (Glomerella lindemuthiana)

Taxonomic identifier

290576 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetes incertae sedis › Phyllachorales › Phyllachoraceae › Glomerella

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 675	675	Serine/threonine-protein kinase ATG1		PRO_0000085643
Regions
	Domain	25 – 328	304	Protein kinase
	Nucleotide binding	31 – 39	9	ATP By similarity
Sites
	Active site	168	1	Proton acceptor By similarity
	Binding site	54	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P87248-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 291B34B386F15C97	FASTA	675	75,107
	10 20 30 40 50 60 MADRLPTSTS SGRRRRDGDA SIGEFVIGGE IGKGSFAQVY SGHHKNSKAA VAIKSVEMGR 70 80 90 100 110 120 LNNKLRENLY GEIQILKTLR HPHIVALHDC VESATHINLV MEYCELGDLS FFIKKRDRHG 130 140 150 160 170 180 TNAATEDMAR KYPVTPGSGL HEVVTRHFLQ QLASALKFLR EKNYVHRDVK PQNLLLLPSP 190 200 210 220 230 240 GFRKENSRPI LTASNDSLIP NAGLASLPML KLADFGFARV LPSTSLADTL CGSPLYMAPE 250 260 270 280 290 300 ILRYERYDAK ADLWSVGTVL YEMITGRPPF RARNHVELLR KIEATEDKVK YPKDAVVSKD 310 320 330 340 350 360 LVKLIGKLLT RNPVERMRFE DFFNDPVVVG PIPGVVEDDI PKVEQKPSRD LRSLEADPQR 370 380 390 400 410 420 EQSELAKSPR ERPLRSPQLP SPDEVRVPQA NVSARTGQSP GREIGEGLGI RRPPMPQPST 430 440 450 460 470 480 SAPSRPHRLS NASLNRPPIR ASASPPTSYL NERKLRPVTE RSMTEQDKAA QDVAFERDYV 490 500 510 520 530 540 VVEKKHVEVN AFADEMAANP RLTSLSPKNG QMVRRATQQG PPTSTTGAGR MQPSSAVQIA 550 560 570 580 590 600 QGKGRPGHDH PCVSLASRSL NTSSAARAPL RPCTTRSPRI RHRHPLLLLD SSVTADRAHH 610 620 630 640 650 660 LTKMHGSSSS SKTSHIVVIV YMALPKSSLS NFSLWHLPWI TPWVAPLPTK SMRMVLLSRQ 670 RWLCLRRLSC FTSRL

References

[1]	Dufresne M., Langin T. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: UPS9.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF000309 Genomic DNA. Translation: AAB61403.1.
3D structure databases
HSSP	HSSP built from PDB template 1NY3 based on UniProtKB P49137.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.1. 20966.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_COLLN

Accession

Primary (citable) accession number: P87248

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)