Reviewed, UniProtKB/Swiss-Prot P87244 (ALP16_SCHPO)

Names and origin

Protein names

Recommended name:
    Spindle pole body component alp16
Alternative name(s):
    Altered polarity protein 16

Gene names

Name:	alp16
ORF Names:	SPCC4G3.19

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	759 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Ref.1
Subunit structure	Interacts with gamma-tubulin. Ref.1
Subcellular location	Cytoplasm › cytoskeleton › spindle pole body. Note: And the microtubule organizing center (MTOC). Ref.1

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW interphase microtubule nucleation by interphase microtubule organizing center Inferred from genetic interaction. Source: GeneDB_SPombe mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	equatorial microtubule organizing center Ref.1 Inferred from direct assay. Source: GeneDB_SPombe gamma-tubulin complex Ref.1 Inferred from direct assay. Source: GeneDB_SPombe microtubule Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW spindle pole body Ref.1 Inferred by curator. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 759	759	Spindle pole body component alp16		PRO_0000064567

Sequences

	Sequence		Length	Mass (Da)
	P87244-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D53A2FC71EA3A8AA	FASTA	759	87,236
	10 20 30 40 50 60 MDGIMKNDLL WFGNHVFDLT PNSFDSDFVE QLSKFEGKEG LKRKLFDSSE YFQNFSFQVN 70 80 90 100 110 120 DDLLGKDVIL DISNQQLTPA VPGCETSSNS KLISASKEIT SERKRAKSSV SPSYLTDSSP 130 140 150 160 170 180 SDLSVENKVL LTCPSWDGEN FKNLEARSPF ISEAPSRVYD YFLHNQDWSP KPLFSALQVY 190 200 210 220 230 240 PLATIFNCVA GLPQGFESTV FPWNKTSSTF ELDPTISVSG MSDECFASIV QKFSAIGGLI 250 260 270 280 290 300 KKALNEFSLY KTNISFYLSN FIVNGVLQYR KEFQRWLRLY EFRRFGLIGL SNFVNSFSSF 310 320 330 340 350 360 FELISHFLIK SAQNLKGDSL LDFLFDYARS CQNTISYPIA LQCLIYCSNP YFKRLELALK 370 380 390 400 410 420 VSCAYGHIDS SLFLSLPRFF PSELCVSIEQ CIQFLSLIRE QKEIFNKNNK EFINPLNIRF 430 440 450 460 470 480 AYSFNDINQA CVIEERCNFS SLSFGNLEQT SVNNDSEEFE TLLAKMNMTP DFNDNLLQLK 490 500 510 520 530 540 FTDDVRNVCP LNLNVCCCIA EPIQSFILSF LRSTYKVLKN DFQVFDLLNF FHSTFLFQNY 550 560 570 580 590 600 EFSDNVISLL KSRRLDKSDR NELAEDLNSD DRYNFISRLK KFIFMEKEKN GLSRSLSKSI 610 620 630 640 650 660 TFTLDSASVS EFEDVYPDLQ FQCQVIGALR ILFTDNSLNY YSKTFSYVLH LFQAQSDFES 670 680 690 700 710 720 SVELKDRSIV TKTTIMSWSK YQGTKESLFQ FLSIYIPECM LPFTKLLKSI YSPDCPTNIQ 730 740 750 NSAIKNAASV HEQCTKAIYQ KVKELFDTMK LWESSIKVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A fourth component of the fission yeast gamma-tubulin complex, Alp16, is required for cytoplasmic microtubule integrity and becomes indispensable when gamma-tubulin function is compromised." Fujita A., Vardy L., Garcia M.-I., Toda T. Mol. Biol. Cell 13:2360-2373(2002) [PubMed: 12134075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB074978 Genomic DNA. Translation: BAB79248.1. CU329672 Genomic DNA. Translation: CAB09763.1.
PIR	T41357.
RefSeq	NP_587819.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P87244.
Genome annotation databases
GeneID	2539309.
GenomeReviews	Gene locus alp16 in contig CU329672_GR.
KEGG	spo:SPCC4G3.19.
NMPDR	fig|4896.1.peg.157.
Organism-specific databases
GeneDB_Spombe	SPCC4G3.19.
Gene expression databases
ArrayExpress	P87244.
Family and domain databases
InterPro	IPR007259. Spc97_Spc98. [Graphical view]
Pfam	PF04130. Spc97_Spc98. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALP16_SCHPO

Accession

Primary (citable) accession number: P87244

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	July 1, 1997
Last modified:	November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)