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Protein

GTPase-activating protein gyp3

Gene

gyp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates exocytosis by functioning as a GAP for ypt2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein gyp3
Gene namesi
Name:gyp3Imported
ORF Names:SPCC4G3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC4G3.09c.
PomBaseiSPCC4G3.09c. gyp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Transmembranei512 – 53221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635GTPase-activating protein gyp3PRO_0000312837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911Phosphoserine1 Publication
Modified residuei193 – 1931Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87234.

PTM databases

iPTMnetiP87234.

Interactioni

Protein-protein interaction databases

MINTiMINT-4692916.

Structurei

3D structure databases

ProteinModelPortaliP87234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 520221Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP87234.
KOiK19953.
OrthoDBiEOG72G1GN.
PhylomeDBiP87234.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGITEHSTI MNDANFKEEN AHLSDASIHF GSSEQDKTPS DYELDDVLDL
60 70 80 90 100
YNDTTEDDAD DADDVNNYIM SPSSSLSSES EHALDALVYP IYSHHNILEH
110 120 130 140 150
ENNSDYASIT PSNHPAFTSC AYLQNPVVDS NNEYESKFRL SLEIPPTDFL
160 170 180 190 200
STSTELSKRE SCLSTETSSS KFSAVTAATI TNETQSEKRS SQTDPSLPFK
210 220 230 240 250
TNSLNCDVTY EEGPLTKKLR GPKKYKPSHS SWDIYGFKKA NQFYTVDQYN
260 270 280 290 300
TWYGPYSRYL ERREQRWKLF LQENGIDYIH QSPSIFPSRS AKTQRFIRKG
310 320 330 340 350
IPPEYRGNAW FYYSGGYELL QRNPKLYETL WRCACIKKPS DSDLIERDLY
360 370 380 390 400
RTFPDNVHFR HKSKHSRNSS DASEHSSEEP DVPMISKLRR VLMTFATYLP
410 420 430 440 450
ENGYCQSLNF LAGFFLLFMS EEKAFWMLVI TCRKYLPKMH DANLEGANID
460 470 480 490 500
QSVLMASVRE SLPAVWSRIS LNFDGIPVND IVAKLPPITL VTAAWFMSAF
510 520 530 540 550
VGILPTETAL RVWDCFFYEG SKVLFMTALC ILRLGEDDIK SKSEQTEVFQ
560 570 580 590 600
VIQDLPKSLL DANAFLSLCF RRNFRRTPSQ KDIERRREKV AKKRNSSASK
610 620 630
LEMSDSSKHH LSRSSSRFSK SHIISQLHNH LKKST
Length:635
Mass (Da):72,790
Last modified:July 1, 1997 - v1
Checksum:i1B1E619846E1EAFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB09776.1.
PIRiT41367.
RefSeqiNP_587829.1. NM_001022822.2.

Genome annotation databases

EnsemblFungiiSPCC4G3.09c.1; SPCC4G3.09c.1:pep; SPCC4G3.09c.
GeneIDi2539298.
KEGGispo:SPCC4G3.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB09776.1.
PIRiT41367.
RefSeqiNP_587829.1. NM_001022822.2.

3D structure databases

ProteinModelPortaliP87234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4692916.

PTM databases

iPTMnetiP87234.

Proteomic databases

MaxQBiP87234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC4G3.09c.1; SPCC4G3.09c.1:pep; SPCC4G3.09c.
GeneIDi2539298.
KEGGispo:SPCC4G3.09c.

Organism-specific databases

EuPathDBiFungiDB:SPCC4G3.09c.
PomBaseiSPCC4G3.09c. gyp3.

Phylogenomic databases

InParanoidiP87234.
KOiK19953.
OrthoDBiEOG72G1GN.
PhylomeDBiP87234.

Miscellaneous databases

NextBioi20800465.
PROiP87234.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND THR-193, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGYP3_SCHPO
AccessioniPrimary (citable) accession number: P87234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.