P87228 (SERA_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 92.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative D-3-phosphoglycerate dehydrogenase Short name=3-PGDH EC=1.1.1.95 | ||
| Gene names |
| ||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||
| Taxonomic identifier | 284812 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | 3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH. |
| Pathway | Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. |
| Sequence similarities | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Serine biosynthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | L-serine biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_Spombe |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro phosphoglycerate dehydrogenase activityInferred from sequence or structural similarity. Source: GeneDB_Spombe |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Putative D-3-phosphoglycerate dehydrogenase | PRO_0000076017 | |||||
Regions | |||||||||
| Nucleotide binding | 205 – 206 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 282 – 284 | 3 | NAD By similarity | ||||||
| Nucleotide binding | 344 – 347 | 4 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 284 | 1 | By similarity | ||||||
| Active site | 313 | 1 | By similarity | ||||||
| Active site | 344 | 1 | Proton donor By similarity | ||||||
| Binding site | 225 | 1 | NAD By similarity | ||||||
| Binding site | 308 | 1 | NAD By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 87 | 1 | Phosphoserine Ref.2 | ||||||
| Modified residue | 258 | 1 | Phosphoserine Ref.2 | ||||||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-258, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329672 Genomic DNA. Translation: CAB09778.1. |
| PIR | T41375. |
| RefSeq | NP_587837.1. NM_001022830.1. |
3D structure databases | |
| ProteinModelPortal | P87228. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P87228. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPCC364.07.1; SPCC364.07.1:pep; SPCC364.07. |
| GeneID | 2539490. |
| KEGG | spo:SPCC364.07. |
| NMPDR | fig|4896.1.peg.175. |
Organism-specific databases | |
| GeneDB_Spombe | SPCC364.07. |
Phylogenomic databases | |
| eggNOG | fuNOG05789. |
| GeneTree | EFGT00050000001276. |
| HOGENOM | HBG731446. |
| OMA | RGGWLKS. |
| OrthoDB | EOG4NGKWJ. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-002412-MONOMER. |
Gene expression databases | |
| ArrayExpress | P87228. |
Family and domain databases | |
| InterPro | IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 2 hits. |
| KO | K00058. |
| Pfam | PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view] |
| PROSITE | PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SERA_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P87228 Secondary accession number(s): O59798 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |